A5076280658- RNA modifications and cancer
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Appendicitis Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- COVID-19 and healthcare impacts
- Epigenetics and DNA Methylation
- Climate Change, Adaptation, Migration
- Lung Cancer Diagnosis and Treatment
- Emergency and Acute Care Studies
- Cancer survivorship and care
- Thyroid Cancer Diagnosis and Treatment
- Geriatric Care and Nursing Homes
- Microtubule and mitosis dynamics
- Reconstructive Surgery and Microvascular Techniques
- Hernia repair and management
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
National Centre for Infectious Diseases
2023
National Cancer Centre Singapore
2015-2020
Singapore General Hospital
2018
National University of Singapore
2015
SingHealth
2015
Carcinoma of the oral tongue (OTSCC) is most common malignancy cavity, characterized by frequent recurrence and poor survival. The last three decades has witnessed a change in OTSCC epidemiological profile, with increasing incidence younger patients, females never-smokers. Here, we sought to characterize genomic landscape determine factors that may delineate genetic basis this disease, inform prognosis identify targets for therapeutic intervention. Seventy-eight cases were subjected...
Genomics-driven cancer therapeutics has gained prominence in personalized treatment. However, its utility indications lacking biomarker-driven treatment strategies remains limited. Here we present a "phenotype-driven precision-oncology" approach, based on the notion that biological response to perturbations, chemical or genetic, ex vivo patient-individualized models can serve as predictive biomarkers for therapeutic clinic. We generated library of "screenable" patient-derived primary...
Treatment failure in solid tumors occurs due to the survival of specific subpopulations cells that possess tumor-initiating (TIC) phenotypes. Studies have implicated G protein-coupled-receptors (GPCRs) cancer progression and acquisition TIC Many GPCRs signal through protein GNA13. In this study, we demonstrate GNA13 is upregulated many impacts metastases patients. levels modulate drug resistance TIC-like phenotypes patient-derived head neck squamous cell carcinoma (HNSCC) vitro vivo....
Socioeconomic status affects survival in patients diagnosed with head and neck squamous cell carcinoma (HNSCC), even health systems universal care. Singapore has a tiered subsidized housing system, which income determines eligibility for subsidies by size of apartment. The objective this study was to assess whether patient's residential type (small/heavily subsidized, medium/moderate subsidy, large/minimal or no subsidy) influenced mortality. A secondary analysis examined smaller apartments...
CRS and HIPEC confer survival benefit in selected patients with peritoneal metatases (PM). Accurate preoperative assessment of disease burden exclusion distant metastases are crucial selecting the appropriate patient. We evaluate utility PET-CT scans comparison CT MRI considered for HIPEC.Data were retrospectively collected from who had been discussed between January 2011 December 2015, at our institutional multidisciplinary tumour board. Patients underwent scan included. Results compared...
Objective Orocutaneous and pharyngocutaneous fistula (OPCF) is a debilitating complication of head neck surgery for squamous cell carcinoma (SCC), resulting in delayed adjuvant treatment prolonged hospitalization. As yet, there no established test that can help prompt accurate diagnosis OPCF. This study aims to determine the accuracy bedside blue dye testing its role as part an algorithm early diagnosis. We also analyze risk factors predisposing Study Design Retrospective cohort from 2012...
Abstract Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with significant perioperative morbidity mortality. We aim to generate validate a biomarker set predicting sensitivity Mitomycin-C refine selection of patients colorectal peritoneal metastasis (CPM) for this treatment. A signature was generated using data from Genomics Drug Sensitivity in Cancer The Genome Atlas. Validation performed on CPM who underwent CRS-HIPEC (n = 62)...
Abstract Background Multidisciplinary team (MDT) meetings or tumor boards (TBs) are fundamental components of cancer treatment. Although their primary function is improved outcomes, this aspect often underreported. The main objective study was to analyze the outcomes patients with head and neck squamous cell carcinoma (HNSCC) discussed at TBs, compare effect adherence nonadherence recommended treatment plans on outcomes. Methods Retrospective data analysis conducted HNSCC those who were...
We have previously identified and validated a panel of molecular prognostic markers (ATP13A3, SSR3, ANO1) for Head Neck Squamous Cell Carcinoma (HNSCC). The aim this study was to investigate the consequence ATP13A3 dysregulation on signaling pathways, aid in formulating therapeutic strategy targeting ATP13A3-overexpressing HNSCC. Gene Set Enrichment Analysis (GSEA) performed HNSCC microarray expression data (Internal local dataset [n = 92], TCGA 232], EMBL 81]) identify pathways associated...
// Chin-Ann J. Ong 1, 3, * , Nicholas B. Shannon 2, Stefan Mueller 7, Sze Min Lek Xuan Qiu 1 Fui Teen Chong 4 Ke Li 2 Kelvin K.N. Koh Gerald C.A. Tay 7 Thakshayeni Skanthakumar 3 Jacqueline S.G. Hwang 5 Tony Kiat Hon Lim Mei Kim Ang 6 Daniel S.W. Tan Ngian-Chye Hiang Khoon Khee Chee Soo and N. Gopalakrishna Iyer 4, Department of General Surgery, Singapore Hospital, S169856, Cancer Stem Cell Biology, Duke-NUS Graduate Medical School, S169857, Division Surgical Oncology, National Centre,...
Objective Robotic and endoscopic approaches have become more accepted in thyroid surgery, with current literature documenting the experience of high‐volume centers. We adopted both concurrently, this series presents our initial to assess practical option for low‐ moderate‐volume centers starting out transaxillary thyroidectomies. Study Design Case chart review. Setting Tertiary academic center. Subjects Methods Over a period 4 years, 101 patients underwent thyroidectomies, whom 48 robotic...
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) improve survival in selected patients with peritoneal metastases. However, only some who are potentially eligible for the procedure considered referred to appropriate surgical department. By studying trends of being CRS HIPEC our centre, we hope better understand demographics patient cohort attitudes physicians involved towards HIPEC.Patients were presented discussed at institution's multidisciplinary tumour...
Retroperitoneal sarcoma represents 15% of sarcomas. The mainstay treatment is surgery where a majority patients require multi-visceral resections that may significantly impact their quality life (QOL) following surgery. Studies in other cancers have shown QOL not be impacted after radical or extensive However, there are limited studies examining the specifically with retroperitoneal sarcoma. In this pilot study, we retrospectively evaluated sarcoma.32 out 90 who underwent surgical...
Background: Socioeconomic status affects survival in patients diagnosed with head and neck squamous cell carcinoma (HNSCC), even health systems universal care. Singapore has a tiered subsidized housing system, which income determines eligibility for subsidies by size of apartment. Aim: The objective this study was to assess whether patient's residential type (heavily public housing, moderately minimally or private type) associated mortality. A secondary analysis examined more heavily...
Abstract Background Multidisciplinary team meetings or tumor boards (TBs) form a pivotal component of oncology practice. The crux TB revolves around making treatment decisions based on succinct head and neck cancer (HNC) patient data presentations, which can be challenging complex. Apart from meticulous discussions plan documentation is equally important. aim this study was to structure an electronic synoptic presentation address all these areas. overarching benefits systematic collection...
There are no well-defined treatment recommendations for elderly patients with advanced head and neck squamous cell carcinoma. This study aimed to investigate whether aggressive among the translated into better survival outcomes.Retrospective cohort study.Single tertiary institution.Elderly (≥60 years) advanced-stage carcinoma (stage III IV) treated between January 1991 May 2014 were reviewed. According current National Comprehensive Cancer Network guidelines, they classified have received...
Abstract Background Patients with head and neck cancer have a higher risk of emergency department (ED) frequent attender (FA). We hypothesized that FAs present issues different from non‐FAs. Methods A retrospective cohort study was conducted on Singapore residents cancers using de‐identified registry merged electronic medical record data. competing regression analysis performed to identify factors associated FA. Aggregated primary diagnoses were compared for patients without FA factors....
Abstract Human‐induced climate change poses a pervasive threat to the world. Human activities, such as deforestation, farming livestock, and burning fossil fuels, are key drivers of change. Like other regions, Southeast Asian region is greatly impacted by The article focuses on examining current landscape adaptation health preparedness among indigenous populations in Asia (SEA). Climate will affect disproportionately. Over years, people living SEA have faced increasing challenges. For...