A5089440321- Head and Neck Surgical Oncology
- Meningioma and schwannoma management
- Head and Neck Cancer Studies
- Bone Tumor Diagnosis and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Immune cells in cancer
- Oral and Maxillofacial Pathology
- Cancer Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Sinusitis and nasal conditions
- Pancreatic and Hepatic Oncology Research
- Tumors and Oncological Cases
- Craniofacial Disorders and Treatments
- Sarcoma Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Reconstructive Surgery and Microvascular Techniques
- Tracheal and airway disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Immunotherapy and Immune Responses
- Cleft Lip and Palate Research
- Glioma Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
Rambam Health Care Campus
2013-2025
American Academy of Otolaryngology — Head and Neck Surgery
2006-2024
Taipei City Government
2024
Temple University
2024
Harvard University
2024
Holy Family Hospital Nazareth
2022-2023
Technion – Israel Institute of Technology
2013-2022
Rappaport Family Institute for Research in the Medical Sciences
2013-2022
University of Haifa
2021
Mount Sinai Hospital
2018
Pancreatic ductal adenocarcinoma (PDAC) is known for its resistance to gemcitabine, which acts inhibit cell growth by termination of DNA replication. Tumor-associated macrophages (TAM) were recently shown contribute gemcitabine resistance; however, the exact mechanism this process still unclear. Using a genetic mouse model PDAC and electron microscopy analysis, we show that TAM communicate with tumor microenvironment via secretion approximately 90 nm vesicles, are selectively internalized...
The current American Joint Committee on Cancer (AJCC) staging system for oral cancer demonstrates wide prognostic variability within each primary tumor stage and provides suboptimal information some patients.To determine if a modified that integrates depth of invasion (DOI) into the T categories improves performance compared with AJCC staging.Retrospective analysis 3149 patients squamous cell carcinoma treated curative intent at 11 comprehensive centers worldwide between 1990 2011 surgery ±...
Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC) limits drug penetration into the tumor and is associated with poor prognosis. Here, we demonstrate that a pretreatment based on proteolytic-enzyme nanoparticle system disassembles dense PDAC collagen stroma increases tumor. More specifically, collagozome, 100 nm liposome encapsulating collagenase, was rationally designed to protect collagenase from premature deactivation prolonged its release rate at target...
Abstract BACKGROUND: The impact of lymph node metastases on prognosis in patients with oral cavity squamous cell carcinoma (OSCC) has been well recognized. However, accurate stratification risk for recurrence among is difficult based the existing staging systems. In current study, utility density (LND) was evaluated as an alternative method predicting survival. METHODS: Three hundred eighty‐six who underwent neck dissection were included. median follow‐up 67 months. Five‐year overall...
The ability of cancer to infiltrate along nerves is a common clinical observation in pancreas, head and neck, prostate, breast, gastrointestinal carcinomas. For these tumors, may provide conduit for local progression into the central nervous system. Although neural invasion associated with poor outcome, mechanism that triggers it unknown.We used an vitro Matrigel dorsal root ganglion pancreatic cell coculture model assess dynamic interactions between migration role glial cell-derived...
Lymph node density (LND) has previously been reported to reliably predict recurrence risk and survival in oral cavity squamous cell carcinoma (OSCC). This multicenter international study was designed validate the concept of LND OSCC. The included 4254 patients diagnosed as having median follow-up 41 months. Five-year overall (OS), disease-specific (DSS), disease-free (DFS), locoregional control distant metastasis rates were calculated using Kaplan–Meier method. (number positive lymph...
An association between the survival of patients with oral cavity squamous cell carcinoma (OCSCC) and advancements in diagnosis therapy has not been established.This was a retrospective, longitudinal, international, population-based study 2738 who underwent resection OCSCC during 2 different decades. Characteristics from 7 international cancer centers received treatment 1990 2000 (group A; n = 735) were compared 2001 2011 B; 2003).Patients group B had more advanced tumors tended to develop...
Abstract Perineural invasion of cancer cells (CPNI) is found in most patients with pancreatic adenocarcinomas (PDA), prostate, or head and neck cancers. These undergo palliative rather than curative treatment due to dissemination along nerves, well beyond the extent any local invasion. Although CPNI a common source distant tumor spread cause significant morbidity, its exact mechanism undefined. Immunohistochemical analysis specimens excised from PDAs showed increase number endoneurial...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It thrives in a nutrient-poor environment; however, mechanisms by which PDAC cells undergo metabolic reprogramming to adapt stress are still poorly understood. Here, we show that microRNA-135 significantly increased patient samples compared adjacent normal tissue. Mechanistically, miR-135 accumulates specifically response glutamine deprivation and requires ROS-dependent activation mutant p53, directly...
<h3>Importance</h3> Immunohistochemistry (IHC) is the most widely used assay for identification of molecular biomarkers. However, IHC time consuming and costly, depends on tissue-handling protocols, relies pathologists' subjective interpretation. Image analysis by machine learning gaining ground various applications in pathology but has not been proposed to replace chemical-based assays detection. <h3>Objective</h3> To assess prediction feasibility expression biomarkers cancer tissues,...
The purpose of this study was to characterize the incidence, pattern spread, and prognostic correlation nerve invasion in patients with adenoid cystic carcinoma (ACC).Using 3 different pathological categories perineural invasion, intraneural inflammation, we investigated value a total 495 ACCs from 9 international patient cohorts median follow-up 90 months (range, 12-288 months).Of 239 (48%) 174 (73%) had 65 (27%) 37 (15%) inflammation. Multivariate Cox regression analysis identified tumor...
Abstract Perineural invasion (PNI) is an ominous event strongly linked to poor clinical outcome. Cells residing within peripheral nerves collaborate with cancer cells enable PNI, but the contributing conditions tumor microenvironment are not well understood. Here, we show that CCR2-expressing inflammatory monocytes (IM) preferentially recruited sites of where they differentiate into macrophages and potentiate nerve through a cathepsin B–mediated process. A series adoptive transfer...
Object. The goal of this study was to develop a disease-specific, multidimensional quality life (QOL) assessment instrument for patients undergoing surgical extirpation anterior skull base tumors. Methods. This investigation included 35 who had been surgically treated more than 3 months before the begun. Relevant QOL questions were generated from review literature and interviews with health professionals, patients, their caregivers. initial multidimensional, 80-item questionnaire reduced...
Objective: To present our method for anterior skull base reconstruction after oncological resections. Methods: One hundred nine patients who had undergone 120 resections of tumors (52 malignant [43%], 68 benign [57%]) via the subcranial approach were studied. Limited dural defects closed primarily or reconstructed using a temporalis fascia. Large by double-layer fascia lata graft. A split calvarial bone graft, posterior frontal sinus wall, three-dimensional titanium mesh used when tumor...