A5027402189- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Advanced Radiotherapy Techniques
- Lung Cancer Treatments and Mutations
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Research Studies
- Oral health in cancer treatment
- Ear and Head Tumors
- Advances in Oncology and Radiotherapy
- Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- COVID-19 and healthcare impacts
- Brain Metastases and Treatment
- Management of metastatic bone disease
- Endometrial and Cervical Cancer Treatments
- Oral and Maxillofacial Pathology
- Gastric Cancer Management and Outcomes
- Radiation Dose and Imaging
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
Homi Bhabha National Institute
2018-2025
Tata Memorial Hospital
2016-2025
Advanced Centre for Treatment, Research and Education in Cancer
2014-2025
Institute for Plasma Research
2024
Dhirubhai Ambani Institute of Information and Communication Technology
2024
Radiation Oncology Associates
2019-2021
Bhabha Hospital
2021
Sri Sathya Sai Institute of Higher Medical Sciences
2007
Niloufer Hospital
1991
Osmania General Hospital
1991
Whether patients with early-stage oral cancers should be treated elective neck dissection at the time of primary surgery or therapeutic after nodal relapse has been a matter debate.In this prospective, randomized, controlled trial, we evaluated effect on survival node (ipsilateral surgery) versus (watchful waiting followed by for relapse) in lateralized stage T1 T2 squamous-cell carcinomas. Primary and secondary end points were overall disease-free survival, respectively.Between 2004 2014,...
The current American Joint Committee on Cancer (AJCC) staging system for oral cancer demonstrates wide prognostic variability within each primary tumor stage and provides suboptimal information some patients.To determine if a modified that integrates depth of invasion (DOI) into the T categories improves performance compared with AJCC staging.Retrospective analysis 3149 patients squamous cell carcinoma treated curative intent at 11 comprehensive centers worldwide between 1990 2011 surgery ±...
Lymph node density (LND) has previously been reported to reliably predict recurrence risk and survival in oral cavity squamous cell carcinoma (OSCC). This multicenter international study was designed validate the concept of LND OSCC. The included 4254 patients diagnosed as having median follow-up 41 months. Five-year overall (OS), disease-specific (DSS), disease-free (DFS), locoregional control distant metastasis rates were calculated using Kaplan–Meier method. (number positive lymph...
An association between the survival of patients with oral cavity squamous cell carcinoma (OCSCC) and advancements in diagnosis therapy has not been established.This was a retrospective, longitudinal, international, population-based study 2738 who underwent resection OCSCC during 2 different decades. Characteristics from 7 international cancer centers received treatment 1990 2000 (group A; n = 735) were compared 2001 2011 B; 2003).Patients group B had more advanced tumors tended to develop...
Background Oral cancer is the most common in Indian males and third females. Tobacco, alcohol, areca nut, human papillomavirus (HPV) are etiologic factors. Each of these agents follows a unique model carcinogenesis that leads to certain distinct presentation behavior. For example, HPV strongly associated with oropharyngeal cancers younger age known have better outcome specific histopathologic characteristics. A high incidence oral submucous fibrosis (OSMF) linked nut (group 1 carcinogen)...
Abstract Background Grade ≥2 acute xerostomia between 3D conformal radiotherapy (RT) and intensity‐modulated (IMRT) was evaluated in patients with head neck squamous cell carcinomas (HNSCCs) treated radically. Methods Between 2005 2007, 59 HNSCC (T1–3, N0–2b) were randomized to IMRT or 3D‐RT. On RT, weekly xerostomia, dysphagia, dermatitis, mucositis graded by Radiation Therapy Oncology Group (RTOG) toxicity criteria. Patients underwent examination under anesthesia, positron emission...
Background and Objectives Certain tumor‐related factors like thickness increases the risk of nodal metastasis may affect survival in patients with oral tongue cancers. The objective this study is to identify those prognostic predictors that can potentially influence decision for adjuvant radiotherapy. Methods A retrospective review all cancers treated primarily by surgery at Tata Memorial Hospital between January 2007 June 2010. demographic commonly reported histopathological features were...
Abstract Purpose To compare long-term disease-related outcomes and late radiation morbidity between intensity-modulated therapy (IMRT) three-dimensional conformal radiotherapy (3D-CRT) in head neck squamous cell carcinoma (HNSCC) the setting of a prospective randomized controlled trial. Methods Previously untreated patients with early to moderately advanced non-metastatic oropharynx, larynx, or hypopharynx (T1-T3, N0-N2b, M0) planned for comprehensive irradiation primary site bilateral nodes...
Grading of gliomas is a piece critical information related to prognosis and survival. Classifying glioma grade by semantic radiological features subjective, requires multiple MRI sequences, quite complex clinically demanding, can very often result in erroneous diagnosis. We used radiomics approach with machine learning classifiers determine the gliomas. Eighty-three patients histopathologically proven underwent brain. Whenever available, immunohistochemistry was additionally augment...
Abstract Background The dominant pattern of failure for squamous cell carcinoma head and neck remains loco-regional, although distant metastases are now being increasingly documented. Radical radiotherapy with concurrent chemotherapy is contemporary standard care in the non-surgical management these loco-regionally advanced cancers, based on large randomized controlled trials utilizing high-dose cisplatin (80–100 mg/m 2 ) cycled every three-weekly during definitive radiotherapy. Although...
Hypopharyngeal cancers have extensive submucosal spread, high risk of nodal involvement and relatively propensity distant metastases. Contemporary paradigms for hypopharyngeal aim to maximize loco-regional control while attempting preserve laryngo-pharyngeal form function.To retrospectively review outcome large cohort patients with treated curative intent radiotherapy or without systemic chemotherapy in an academic tertiary referral centre.Medical records primary non-surgical approaches over...
To evaluate the prognostic role of lymph node ratio (LNR; total positive nodes to dissected nodes) in oral squamous cell carcinoma (OSCC) as compared pN staging with an aim provide optimal cut-off value.1,408 OSCC previously untreated patients who underwent treatment (surgery + neck dissection adjuvant treatment). LNR sensitivity respect survival was calculated using receiver operating characteristic (ROC) curves and Cox regression method. TNM variables were subjected multivariate...
BACKGROUND A study was conducted to assess for prognostic heterogeneity within the N2b and N2c classifications oral cancer based on number of metastatic lymph nodes determine whether laterality neck disease provides additional information. METHODS An international multicenter 3704 patients with undergoing surgery curative intent performed. The endpoints interest were disease‐specific survival overall survival. Model fit assessed by Akaike Information Criterion comparison models without...
This prospective study compared <sup>177</sup>Lu-ethylene diamine tetramethylene phosphonate (EDTMP) with <sup>153</sup>Sm-EDTMP for painful skeletal metastases. <b>Methods:</b> Half of the 32 patients were treated <sup>177</sup>Lu-EDTMP and half <sup>153</sup>Sm-EDTMP, at 37 MBq/kg body weight. Analgesic, pain, quality-of-life scores (EORTC, Karnofsky, ECOG) bone proliferation marker used to examine efficacy. Hematologic toxicity was evaluated using NCI-CTCAE between groups baseline each...