A5100675986- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Insect Resistance and Genetics
- Viral Infectious Diseases and Gene Expression in Insects
- MicroRNA in disease regulation
- Angiogenesis and VEGF in Cancer
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Electrospun Nanofibers in Biomedical Applications
- Virus-based gene therapy research
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Tissue Engineering and Regenerative Medicine
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- RNA modifications and cancer
- Mitochondrial Function and Pathology
- Cardiac and Coronary Surgery Techniques
- DNA Repair Mechanisms
- Cardiac Valve Diseases and Treatments
- Antimicrobial Peptides and Activities
Hebei University
2024-2025
City of Hope
2013-2024
Beckman Research Institute
2012-2024
City Of Hope National Medical Center
2014-2024
Xuzhou Medical College
2017-2023
South China Agricultural University
2023
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2023
Ruijin Hospital
2011-2023
First Affiliated Hospital of Guangzhou Medical University
2021
State Key Laboratory of Respiratory Disease
2021
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It thrives in a nutrient-poor environment; however, mechanisms by which PDAC cells undergo metabolic reprogramming to adapt stress are still poorly understood. Here, we show that microRNA-135 significantly increased patient samples compared adjacent normal tissue. Mechanistically, miR-135 accumulates specifically response glutamine deprivation and requires ROS-dependent activation mutant p53, directly...
Kinesin family member 4A (KIF4A) was found to be implicated in the regulation of chromosome condensation and segregation during mitotic cell division, which is essential for eukaryotic proliferation. However, little known about role KIF4A colorectal carcinoma (CRC). This study explored biological function CRC progression investigated potential molecular mechanisms involved. Here, we that remarkably upregulated primary tissues lines compared with paired non-cancerous normal epithelium....
Highlights•Glutamine deprivation induces Slc7a3 in a p53-dependent manner•Intracellular arginine increases upon glutamine manner•Slc7a3 expression contributes to mTORC1 activation during depletion•Knock down of results delayed xenograft tumor growthSummaryCancer cells heavily depend on the amino acid meet demands associated with growth and proliferation. Due rapid consumption glutamine, cancer frequently undergo starvation vivo. We others have shown that p53 is critical regulator metabolic...
Abstract Tumour cells adapt to nutrient deprivation in vivo, yet strategies targeting the poor microenvironment remain unexplored. In melanoma, tumour often experience low glutamine levels, which promote cell dedifferentiation. Here, we show that dietary supplementation significantly inhibits melanoma growth, prolongs survival a transgenic mouse model, and increases sensitivity BRAF inhibitor. Metabolomic analysis reveals uptake of effectively concentration tumours its downstream metabolite,...
Targeting transcription replication conflicts, a major source of endogenous DNA double-stranded breaks and genomic instability could have important anticancer therapeutic implications. Proliferating cell nuclear antigen (PCNA) is critical to repair processes. Through rational drug design approach, we identified small molecule PCNA inhibitor, AOH1996, which selectively kills cancer cells. AOH1996 enhances the interaction between largest subunit RNA polymerase II, RPB1, dissociates from...
Abstract Cancer radiotherapy may be immunogenic, but it is unclear why its immunogenic effects are rarely sufficient to prevent tumor recurrence. Here, we report a novel Toll-like receptor 9 (TLR9)–dependent mechanism that initiates regrowth after local radiotherapy. Systemic inhibition of TLR9, not TLR4, delayed recurrence in mouse models B16 melanoma, MB49 bladder cancer, and CT26 colon cancer localized high-dose irradiation. Soluble factors the microenvironment regressing tumors triggered...
Background MicroRNAs (miRNAs) regulate a lot of physiological and pathological processes, including myocardial ischemia/reperfusion. Recent studies reported that knockdown miR-92a could attenuate ischemia/reperfusion-induced injury. In the present study, we examined potential anti-apoptotic effects in rat myocardiocyte cell line, possible role Smad7 such actions. Methodology Results preliminary bioinformatic analysis, identified SMAD family member 7 (Smad7) as target for miR-92a. A...
The use of biomass for cooking and heating is considered an important factor associated with chronic obstructive pulmonary disease (COPD), but few studies have previously addressed its underlying mechanisms. Therefore, this research aimed to evaluate the effects biomass-related PM2.5 (BRPM2.5) exposure on 16HBE human airway epithelial cells in mice regard mitochondrial dysfunction. Our study indicated that BRPM2.5 resulted dysfunction, including decreased membrane potential, increased...
Abstract DNA methylation is a fundamental epigenetic modification regulating gene expression. Aberrant the most common molecular lesion in cancer cells. However, medical intervention has been limited to use of broadly acting, small molecule-based demethylating drugs with significant side-effects and toxicities. To allow for targeted demethylation, we integrated two nucleic acid-based approaches: DNMT1 interacting RNA (DiR) aptamer strategy. By combining inherent capabilities inhibiting an...
A spectrum of immune states resulting from tumor resident macrophages and T-lymphocytes in the solid microenvironment correlates with patient outcomes. We hypothesized that gastric cancer (GC), a polarized immunosuppressive transcriptional state would be prognostic poor survival. derived transcriptomic signatures for M2 (M2TS, MRC1; MS4A4A; CD36; CCL13; CCL18; CCL23; SLC38A6; FGL2; FN1; MAF) M1 (M1TS, CCR7; IL2RA; CXCL11; CCL19; CXCL10; PLA1A; PTX3) macrophages, cytolytic (CTLTS, GZMA; GZMB;...
The application of polyelectrolyte multilayer films is a new, versatile approach to surface modification decellularized tissue, which has the potential greatly enhance functionality engineered tissue constructs derived from organs. In present study, we test hypothesis that Heparin- vascular endothelial growth factor (VEGF) film can not only act as an antithrombotic coating reagent, but also induce proliferation progenitor cells (EPCs) on aortic heart valve. SEM demonstrated adhesion and...
The development of new antibiotics with novel antimicrobial mechanisms and strategies has attracted considerable interest. Herein, three amphiphilic lysine-based glycopeptides (SA-l-Gal, OA-l-Gal LOA-l-Gal) were developed, their antibacterial activity inhibition effects on biofilm formation P. aeruginosa studied. SA-l-Gal a stearic acid group modification exhibited better than the other by damaging bacterial membrane. Furthermore, could effectively reduce inflammation factor expression,...
The importance of cell adhesion to the scaffold in tissue-engineered heart valve remains be determined. current study examined feasibility conjugating antibody against CD90 a decellularized porcine aortic and binding mesenchymal stem cells that through interaction with surface antigen. After decellularization, was reacted biotin, avidin, biotinylated anti-rat sequentially inserted into laminar flow system used test effect shear stress. Rat bone (BMSC) were injected circulated ability...
Abstract Formyl peptide receptor 2 (FPR2), a classical chemoattractant of G-protein-coupled receptors, is reported to be involved in invasion and metastasis some cancers, but the role FPR2 gastric cancer (GC) has not yet been elucidated. In this study, we found that levels expression GC were positively correlated with depth, lymph node negatively patients’ overall survival. Multivariate analysis indicated was an independent prognostic marker for patients. FPR2-knockdown significantly...
Abstract Id1 and Id3 genes are required for vascularization, growth, metastasis of xenograft tumors. In Id-deficient mice, tumor transplantation proangiogenic factors fail to mobilize recruit circulating endothelial precursor cells (CEPs) hematopoietic cells, leading defective angiogenesis in various models. To investigate the requirement Id bone marrow incorporation spontaneous prostate tumors, we crossbred mutant mice with transgenic adenocarcinoma mouse (TRAMP) mice. Id1−/− Id3+/− TRAMP...
Many carcinogens leave a unique mutational fingerprint in the human genome.These fingerprints manifest as specific types of mutations often clustering at certain genomic loci tumor genomes from carcinogen-exposed individuals.To develop high-throughput method for detecting carcinogens, we have devised cost-, time-and labor-effective strategy, which widely used transgenic Big Blue Õ mouse mutation detection assay is made compatible with Roche/454 Genome Sequencer FLX Titanium next-generation...
Oncogenic (mutant) Ras protein Kirsten rat sarcoma viral oncogene homolog (KRAS) promotes uncontrolled proliferation, altered metabolism, and loss of genome integrity in a cell-intrinsic manner. Here, we demonstrate that CD4+ T cells when incubated with tumor-derived exosomes from mutant (MT) KRAS non-small-cell lung cancer (NSCLC) cells, patient sera, or mouse xenograft model, induce phenotypic conversion to FOXP3+ Treg-like are immune-suppressive. Furthermore, transfecting MT cDNA alone...
Signaling of transforming growth factor β (TGF-β) is redirected in cancer to promote malignancy, but how TGF-β function altered a transformed cell not fully understood. We investigated signaling by profiling proteins that differentially bound type I receptor (TβRI) nontransformed, HER2-transformed, and HER2-negative breast cells using immunoprecipitation followed protein identification. Interestingly, several nuclear implicated posttranscriptional RNA processing were uniquely identified the...