A5103174763- Acute Kidney Injury Research
- Peroxisome Proliferator-Activated Receptors
- Sepsis Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Heme Oxygenase-1 and Carbon Monoxide
- Thermal Regulation in Medicine
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Kruppel-like factors research
- Intensive Care Unit Cognitive Disorders
- Drug-Induced Hepatotoxicity and Protection
- Medicinal Plants and Bioactive Compounds
- Eicosanoids and Hypertension Pharmacology
- Liver Disease and Transplantation
- Cancer, Hypoxia, and Metabolism
- Sulfur Compounds in Biology
- Anesthesia and Sedative Agents
- Hydrogen's biological and therapeutic effects
- Mitochondrial Function and Pathology
- Respiratory Support and Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Chronic Kidney Disease and Diabetes
- Climate Change and Health Impacts
- Biomarkers in Disease Mechanisms
- Respiratory viral infections research
- Thermoregulation and physiological responses
Ningbo University
2023-2025
Affiliated Hospital of Chengde Medical College
2025
Ningbo First Hospital
2014-2024
Ningxia Medical University
2013-2024
Novartis (China)
2024
Tianjin Medical University
2024
Shandong First Medical University
2023
Wuhan Union Hospital
2020-2022
Tianjin Fourth Central Hospital
2019-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2017-2020
Chronic glucocorticoid therapy has serious side effects, including diabetes and fatty liver. However, the molecular mechanisms responsible for steroid-induced remain largely enigmatic. Here, we show that hepatic Krüppel-like factor 9 (Klf9) gene expression is induced by dexamethasone fasting. The overexpression of Klf9 in primary hepatocytes strongly stimulated Pgc1a through direct binding to its promoter, thereby activating gluconeogenic program. mutation abolished stimulatory effect on...
Abstract The mechanisms underlying glucocorticoid (GC)-induced obesity are poorly understood. Macrophages the primary targets by which GCs exert pharmacological effects and perform critical functions in adipose tissue homeostasis. Here, we show that macrophages essential for GC-induced obesity. Dexamethasone (Dex) strongly induced Krüppel-like factor 9 ( Klf9 ) expression macrophages. Similar to Dex, lentivirus-mediated overexpression inhibits M1 M2a markers expression, causing macrophage...
Sterol regulatory element binding proteins (SREBPs) are master regulators of hepatic lipid homeostasis.Aberrant expression SREBPs frequently leads to metabolism dysregulation.Long non-coding RNAs (lncRNAs) have been identified with diverse biological functions, but the effects lncRNAs on rarely reported.Here, we a novel human specific lncRNA, lncHR1, as negative regulator SREBP-1c expression.Overexpression lncHR1 inhibited and fatty acid synthase (FAS) then repressed oleic acid-induced cell...
Pyroptosis is considered to play an important role in the occurrence, development and prognosis of septic acute kidney injury (SAKI). We aimed explore specific molecular mechanism S-nitrosoglutathione (SNG) regulating pyroptosis tubular epithelial cells (KTECs). By constructing a mice model sepsis, we pretreated them with SNG used biochemical methods detect levels serum inflammatory factors mitochondrial reactive oxygen species (mtROS), assessed severity KTECs damage, detected expression...
Multidrug resistance (MDR) is one of the primary causes chemotherapy failure in colorectal cancer (CRC), and extensive biological studies into MDR are required. The non‑coding RNA plasmacytoma variant translocation 1 (PVT1) has been demonstrated to be associated with low survival rates patients CRC. However, whether PVT1 serves a critical function CRC remains determined. To determine association between expression 5‑fluorouracil (5‑FU) CRC, levels mRNA 5‑FU‑resistant tissues cell lines...
Abnormalities of blood system often occur several days before acute kidney injury (AKI) in patients with heat stroke (HS). We aimed to investigate the prevalence and prognostic value early hematological markers AKI induced by HS.In a retrospective cohort study, we analyzed case records 176 HS evaluated for prediction risk classification AKI.Of 176, 103 (58%) cases developed AKI, men comprised more than half (75%) sample population. The nadir platelet count significantly correlated levels...
Promoting development and function of brown beige fat may represent an attractive treatment obesity. In the current study, we show that Klf9 expression is markedly induced by cold exposure a β-adrenergic agonist. Moreover, levels in human white adipose tissue (WAT) are inversely correlated with adiposity, overexpression primary cells stimulates cellular thermogenesis, which Ucp1 dependent. Fat-specific transgenic mice gain less weight have smaller pads due to increased thermogenesis fat....
Long non-coding RNA (lncRNA) plays a very important role in the occurrence and development of various tumors, is potential biomarker for cancer diagnosis prognosis. The purpose this study was to investigate relationship between expression lncRNA plasmacytoma variant translocation 1 (PVT1) prognostic significance patients with colorectal cancer.The PVT1 measured by real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) cancerous adjacent tissues 210 patients....
To explore the regulation mechanism of Sirtuin 3 (SIRT3) on mitochondrial function and apoptosis acute kidney injury (AKI) in septic mice. The sepsis-induced AKI model was constructed wild-type SIRT3 knockout (KO) mice, levels serum creatinine (Scr) plasma molecule 1 (pKIM-1) mice were detected by ELISA. damage tubular epithelial cells (KTEC) observed electron microscopy, KTEC TUNEL assay, mRNA SIRT3, Bax, Caspase-3, Bcl-2 RT-qPCR. KO caused increased expression Scr, pKIM-1, inducible nitric...
Objective. We aimed to investigate the protective effect of s-nitrosoglutathione (SNG) pretreatment on acute kidney injury (AKI) in septic rats. Methods. constructed a rat model sepsis by cecal ligation and puncture observed survival obtained blood samples from rats, pathological damage tissues, evaluated function expression levels inflammatory factors. also detected induced nitric oxide synthase (iNOS) cyclooxygenase-2 (COX-2) kidneys immunohistochemistry apoptosis tubular epithelial cells...
Purpose: To clarify the protective effect and mechanism of salidroside (SLDS) on acute kidney injury (AKI) in septic rats. Methods: We pretreated rats with different doses SLDS analyzed impact survival evaluated levels inflammatory factors rats, expression NF-ƙB p65 kidney, apoptosis tubular epithelial cells (KTECs). Results: significantly decreased mortality it reduced TNF-α, IL-1β, IL-17A plasma kidneys serum creatinine, renal molecule-1 neutrophil gelatin-associated lipocalin. Moreover,...
Patients with lichen planus (LP) refractory to available therapies often experience a high disease burden, representing population clear unmet need for new treatments.
To investigate the protective effect of N-acetylcysteine (NAC) on septic acute kidney injury (SAKI) via regulating Sirtuin3 (SIRT3)-mediated mitochondrial dysfunction and apoptosis.
Urine neutrophil gelatinase-associated lipocalin (uNGAL) is a rapidly emerging biomarker for early detection of acute kidney injury (AKI). We aimed to investigate the prevalence and prognostic value uNGAL in patients with AKI induced by sepsis.In this prospective cohort study, we analyzed case records 126 septic without evaluated prediction risk stratification AKI.Of analyzed, 58 (46%) developed AKI. Men comprised more than half (68%) sample population, mean age (SD) was 57 years. The...
The aim of the study was to confirm whether higher levels urinary neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1) and N-acetyl-β-D-glucosaminidase (NAG) are associated with mortality risk scores in severe septic patients acute (AKI).A prospective observational performed an adult critical care unit. A total 135 were included. NGAL, KIM-1 NAG compared between physiology chronic health evaluation (APACHE II) score > 25 (group A, n = 31) APACHE II ≤ B,...
We aimed to investigate the diagnostic value of microRNA-155 (miR-155) for acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) in patients with sepsis.In this prospective study, we used Spearman correlation analysis relationships between miR-155 expression and inflammatory factors, oxygenation ratio (PaO2/FiO2), ALI/ARDS score, area under receiver operating characteristic curve (AU-ROC) evaluate miR-155's accuracy total, 156 sepsis were enrolled our which 41 had ALI 32 ARDS....
Acute lung injury (ALI) is a common comorbidity in patients with sepsis, and finding drugs that can effectively reduce its mortality hot spot current research. The purpose of this study to explore the protective mechanism N-acetylcysteine (NAC) on ALI septic rats.We used NAC intervene rats evaluate plasma inflammatory factors tissue pathological damage. Biochemical methods were determine levels oxidases tissue, expression inducible nitric oxide synthase (iNOS) endothelial (eNOS) proteins,...