A5036227462- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- RNA Interference and Gene Delivery
- Immune cells in cancer
- RNA Research and Splicing
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Myasthenia Gravis and Thymoma
- Sarcoma Diagnosis and Treatment
- Kruppel-like factors research
- Pharmacogenetics and Drug Metabolism
- Dermatological and COVID-19 studies
- Liver Diseases and Immunity
- Lymphatic Disorders and Treatments
Hangzhou Normal University
2025
Henan Normal University
2025
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
Tianjin Medical University
2022-2024
Fujian Medical University
2015-2024
Shanghai Jiao Tong University
2024
Fudan University
2015-2023
Zhongshan Hospital
2016-2023
First Affiliated Hospital of Fujian Medical University
2019-2023
<h3>Background</h3> Intrahepatic cholangiocarcinoma (ICC) is a highly mortal malignancy with limited therapeutic options. Immunotherapies targeting PD-1/PD-L1 pathway represent promising treatment for ICC. However, PD-L1 expression and microsatellite instability are not common in This study aimed to investigate whether HHLA2, newly identified B7 family immune checkpoint T cells, could be target next <h3>Methods</h3> Expression levels of HHLA2 as well infiltrations CD3+, CD8+, CD4 + Foxp3+,...
Aberrant expression of interleukin-35 (IL-35) has been implicated in dampening antitumour immunity. The aim this study was to explore the prognostic significance IL-35 patients with hepatocellular carcinoma (HCC) following curative resection. Furthermore, we aimed formulate an effective nomogram for HCC after hepatectomy.Immunohistochemistry applied as well CD39(+)Foxp3(+) and Foxp3(+) regulatory T cell (Treg) infiltration tissue microarrays primary cohort comprising 210 randomly selected...
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1), a long non-coding RNA, has been documented to be new prognostic marker and gene regulator in several types of cancer, but its potential involvement acute myeloid leukemia (AML) remains unclear. This study investigated the expression functional role MALAT-1 AML. was assessed by real-time quantitative PCR. After lentiviral-mediated knockdown, proliferation AML cells determined CCK-8 colony formation assays. Cell cycle...
Abstract Primary liver cancer (PLC) poses a leading threat to human health, and its treatment options are limited. Meanwhile, the investigation of homogeneity heterogeneity among PLCs remains challenging. Here, using single-cell RNA sequencing, spatial transcriptomic bulk multi-omics, we elaborated molecular architecture 3 PLC types, namely hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) combined hepatocellular-cholangiocarcinoma (CHC). Taking high-resolution...
A subgroup analysis of a randomized study demonstrated that patients with advanced or metastatic liposarcoma treated eribulin had longer overall survival and progression-free compared to those dacarbazine, suggesting as therapeutic option for liposarcoma. Therefore, this aims evaluate the cost-effectiveness versus dacarbazine in treatment We established 10-year Markov model compare regimens. Clinical data were sourced from multicenter, randomized, open-label phase 3 trials. Quality-adjusted...
Infrared (IR) camouflage has garnered growing attention with progress in IR detection technology. The emergence of metamaterial powerful electromagnetic field regulation ability provides an effective solution for thermal emission manipulation camouflage. However, the intricated micro/nano machining technology greatly limits its moving toward practical application, and single-band makes it difficult to resist multiband cooperative systems. Here, a flexible, fine, mask-free femtosecond laser...
The hindgut of horses is an anaerobic fermentative chamber for a complex and dynamic microbial population, which plays critical role in health energy requirements. Research on the gut microbiota Mongolian has not been reported until now as far we know. horse major local breed China. We performed high-throughput sequencing 16S rRNA genes V4 hypervariable regions from fecal material to characterize compare them Thoroughbred horses. Fourteen 19 were used study. A total 593,678 sequence reads...
// Chu-Yu Jing 1, * , Yi-Peng Fu Hu-Jia Shen Su-Su Zheng 1 Jia-Jia Lin Yong Yi Jin-Long Huang Xin Xu Juan Zhang Jian Zhou Jia Fan Zheng-Gang Ren Shuang-Jian Qiu Bo-Heng The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis Invasion, Chinese Ministry of Education, Shanghai, P.R. China. These authors have contributed equally to this work Correspondence to: Zhang, email: zhang.boheng@zs-hospital.sh.cn Keywords: albumin,...
Video-assisted thoracoscopic extended thymectomy (VATET) is commonly performed bilaterally to remove all the thymic tissue in mediastinum for surgical treatment of myasthenia gravis. We hypothesize that therapeutic efficacy unilateral (right-sided) comparable bilateral VATET.We retrospectively reviewed 103 consecutive patients who received VATET non-thymomatous gravis (NTMG), with a minimum follow-up period 36 months.Bilateral was first 31 and right-sided following 72. No died...
Early identification of severe acute pancreatitis (SAP) progression is important in (AP) treatment. The Ranson, APACHE II and CTSI systems are difficult to use exhibit limited predictive value. Prealbumin fibrinogen phase reactants generally used assess the nutritional statuses coagulation functions AP patients, respectively. Here, we explored value combination these two markers for evaluating severity prognosis.One hundred sixty-nine including mild (MAP) (n = 101) patients 68), were...
Background: While curative resection is the established strategy for Hepatocellular carcinoma (HCC) patients, prognosis still remains poor, and efficiency of existing prediction models unsatisfactory.Therefore, we aimed to develop a credible easy-to-use prognostic index patients with HCC undergoing therapy.Methods: A total 768 HCC, who underwent from December 2010 June 2012 in Zhongshan Hospital, were divided into training cohort 616 validating 152 at ratio 4 1 by random allocation.Then,...
Abstract Background Immune checkpoint inhibitors (ICIs) have demonstrated superior clinical efficacy in prolonging overall survival (OS) as the second-line treatment for advanced or metastatic esophageal squamous cell carcinoma (ESCC), and were recommended by guidelines. However, it remains uncertain which ICI is most cost-effective. This study assessed cost-effectiveness of ICIs ESCC based on perspective Chinese healthcare system. Methods A network meta-analysis (NMA) was performed to...
Abstract Background Epigenetic abnormalities in acute myeloid leukaemia provide us with a target for novel therapeutic strategies. The aim of the study was to verify epigenetic regulatory mechanism E‐cadherin gene silencing induced by long non‐coding RNA MALAT‐1 AML. Methods Expression MALAT‐1, , EZH2 SUZ12 and EED genes AML patients detected RT‐qPCR. After cell lines, levels DNMT1 DNMT3A DNMT3B encoded proteins were RT‐qPCR Western blotting. level CpG island methylation trimethylation...
The present study was designed to investigate the relationship among epigenetic changes in Wnt antagonists, histone H4K20me1 and expression of tumor-suppressor genes acute leukemia (AL) better understand pathogenesis leukemia. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) performed detect messenger RNA (mRNA) levels antagonists (Wnt5a, HDPR1, DKK1 DKK3) patients with AL normal controls; pyrophosphate sequencing methylation status Wnt5a promoter; western blotting...
To further clarify the association between abnormal levels of serum lipid components as main features dyslipidaemia and hepatocellular carcinoma, which remains unclear.We examined level lipids apolipoproteins pattern in 471 patients undergoing curative resection for HCC, 193 with chronic liver disease, 104 benign diseases. We performed uni- multivariate analyses to evaluate predictive roles recurrence survival HCC a training cohort 242 then validated 229 patients.The majority circulating...