A5102965429- Aquaculture disease management and microbiota
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Animal Virus Infections Studies
- Dialysis and Renal Disease Management
- Identification and Quantification in Food
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Bacteriophages and microbial interactions
- Viral Infectious Diseases and Gene Expression in Insects
- Monoclonal and Polyclonal Antibodies Research
- Extracellular vesicles in disease
- Cancer, Lipids, and Metabolism
- Invertebrate Immune Response Mechanisms
- Animal Disease Management and Epidemiology
- Inflammasome and immune disorders
- Acute Kidney Injury Research
- Viral Infections and Vectors
- Aquaculture Nutrition and Growth
- Vasculitis and related conditions
- Muscle and Compartmental Disorders
- Fish Biology and Ecology Studies
- Plant Virus Research Studies
- Mosquito-borne diseases and control
- Phagocytosis and Immune Regulation
Xiyuan Hospital
2022-2025
China Academy of Chinese Medical Sciences
2023-2025
Beijing Hua Xin Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
Second Affiliated Hospital of Harbin Medical University
2024
Harbin Medical University
2024
Ministry of Education of the People's Republic of China
2024
Henan Provincial People's Hospital
2020-2022
First Affiliated Hospital of Henan University
2018-2021
Henan University
2020-2021
Rationale: Posttranslational modifications of proteins have not been addressed in studies aimed at elucidating the cardioprotective effect exercise atherosclerotic cardiovascular disease (ASCVD).In this study, we reveal a novel mechanism by which ameliorates atherosclerosis via lactylation.Methods: Using ApoE -/-mice an model, proteomics analysis was used to identify exercise-induced specific lactylation MeCP2 lysine 271 (K271).Mutation K271 site aortic plaque macrophages achieved...
Inflammation-induced podocyte apoptosis plays an important role in kidney injury during diabetic nephropathy (DN). Hirudin (HIR), a natural compound extracted from leeches, can inhibit inflammation. However, whether HIR protect the kidneys against inflammation DN is unknown. In present study, we aimed to study effects of on damage rat model and explore its anti-inflammatory properties.A streptozotocin-induced was generated, administered subcutaneously. Immortal podocytes primary peritoneal...
This study aims to investigate the therapeutic effects of modified Huangqi Chifeng decoction (MHCD) on proteinuria in membranous nephropathy (MN) and its potential protective podocytes. Furthermore, we explored whether these are associated with inhibition nuclear factor kappa-B (NF-κB) pathway. Passive Heymann nephritis (PHN) rat model was applied a single tail vein injection sheep anti-rat Fx1A serum (0.4 ml/100g). All rats were divided into four groups: normal group, PHN benazepril group...
Background This study aims to investigate the relationship between blood urea nitrogen serum albumin ratio (BAR) and all-cause mortality in patients with acute kidney injury (AKI) evaluate effect of BAR on prognosis AKI. Methods Adult AKI admitted ICU Medical Information Mart for Intensive Care IV (MIMIC-IV) were selected a retrospective cohort study. (mg/g) was calculated using initial (mg/dl)/serum (g/dl). According BAR, these divided into quartiles (Q1–Q4). Kaplan–Meier analysis used...
The study is aimed at investigating the effects of Ginkgo biloba extract EGB761 on renal tubular damage and endoplasmic reticulum stress (ERS) in diabetic kidney disease (DKD). A total 50 C57BL/6 N mice were randomly divided into normal group, DKD DKD+EGB761 group (36 mg/kg), DKD+4-phenylbutyrate (4-PBA) (1 g/kg). model was replicated by high-fat diet combined with intraperitoneal injection streptozotocin (STZ). Renal epithelial cells (HK-2) control high-glucose (30 mmol/L), (40 mg/L, 20 10...
The triglyceride glucose (TyG) index is a novel and reliable alternative marker for insulin resistance. Previous studies have shown that TyG closely associated with cardiovascular outcomes in diseases coronary revascularization. However, the relationship between renal of revascularization unclear. purpose this study was to investigate correlation risk acute kidney injury (AKI) patients A retrospective cohort conducted select eligible admitted ICU medical information mart intensive care IV...
BACKGROUND:This study aimed to investigate the effects of hirudin on production extracellular matrix (ECM) factors by renal tubular epithelial cells in a rat model diabetic kidney disease (DKD) and HK-2 human tubule cells. MATERIAL AND METHODS:Sprague-Dawley rats were divided into normal control group (n=10), control+hirudin DKD (n=12) DKD+hirudin (n=12). At end study, histopathology was undertaken, expression type IV collagen, fibronectin, hypoxia-inducible factor-1α (HIF-1α), vascular...
Abstract Introduction Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis (PD). Combination therapies are emerging as promising treatment for tissue damage. Here, we investigated the therapeutic potential SIRT1-modified human umbilical cord mesenchymal stem cells (hUCMSCs) fibrosis. Methods SIRT1 was overexpressed in hUCMSCs to establish hUCMSCs. Co-culture and transplantation experiments were performed TGF-β-stimulated Met-5A damage rodent model assess through...
Background Successive observational studies have highlighted low-density lipoprotein cholesterol (LDL-C) as a standalone risk factor for the progression of chronic kidney disease (CKD) to end-stage renal disease. Lowering LDL-C levels significantly reduces incidence atherosclerotic events in patients with progressive CKD. Recent research indicates that proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors not only effectively lower CKD but also exhibit therapeutic potential autoimmune...