A5101875682- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Inflammasome and immune disorders
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Pharmacological Effects of Natural Compounds
- Renin-Angiotensin System Studies
- RNA modifications and cancer
- Advanced Breast Cancer Therapies
- Cerebrovascular and genetic disorders
- Advanced Glycation End Products research
- Estrogen and related hormone effects
- Erythropoietin and Anemia Treatment
- Pregnancy and preeclampsia studies
- Ginseng Biological Effects and Applications
- Ginkgo biloba and Cashew Applications
- Renal cell carcinoma treatment
- Cardiac tumors and thrombi
- Cytomegalovirus and herpesvirus research
- Uterine Myomas and Treatments
- Angiogenesis and VEGF in Cancer
- Ovarian cancer diagnosis and treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Endometrial and Cervical Cancer Treatments
- Vascular Tumors and Angiosarcomas
Henan University of Traditional Chinese Medicine
2020-2024
First Affiliated Hospital of Henan University
2018-2023
Baotou Medical College
2023
Henan Provincial People's Hospital
2020-2022
Background: Renal cell carcinoma (RCC) is one of the most common malignancies urinary system and ferroptosis considered as a promising therapeutic approach for treating RCC. Ginsenoside Rh4 (Rh4) was proved to have anticancer properties play roles in ferroptosis. This study aimed investigate potential ginsenoside enhancing sensitivity renal cells elucidate underlying mechanisms. Methods: RCC lines 786-O ACHN were treated with RAS-selective lethal 3 (RSL3) and/or Rh4. Cell-viability assays...
Inflammation-induced podocyte apoptosis plays an important role in kidney injury during diabetic nephropathy (DN). Hirudin (HIR), a natural compound extracted from leeches, can inhibit inflammation. However, whether HIR protect the kidneys against inflammation DN is unknown. In present study, we aimed to study effects of on damage rat model and explore its anti-inflammatory properties.A streptozotocin-induced was generated, administered subcutaneously. Immortal podocytes primary peritoneal...
Objective: This study aimed to investigate the potential of combining cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors with curcumin (Cur), a natural compound known for its anti-aging properties, enhance anti-cancer efficacy in prostate cancer (PCa). Methods: The cell viability was determined by counting kit-8 assay, colony forming assay invasion. cycle mRNA levels p16 (cyclin dependent inhibitor 2A, CDKN2A), p21 1A, CDKN1A) <i>Rb</i> (RB transcriptional corepressor) were detected flow...
Sirtuin-3 (SIRT3) has been described as a colorectal cancer oncogene and to be regulated by glycyrrhizic acid (GA). However, few studies have explored the interaction between GA SIRT3. Therefore, in present study, we showed that could significantly decrease SIRT3 protein levels SW620 HT29 cells dose-dependent manner. Then, overexpressed lentivirus infection on cells. We found that, vitro, treatment decreased cell viability, clone number, invasion migration besides increasing apoptosis. Also,...
The study is aimed at investigating the effects of Ginkgo biloba extract EGB761 on renal tubular damage and endoplasmic reticulum stress (ERS) in diabetic kidney disease (DKD). A total 50 C57BL/6 N mice were randomly divided into normal group, DKD DKD+EGB761 group (36 mg/kg), DKD+4-phenylbutyrate (4-PBA) (1 g/kg). model was replicated by high-fat diet combined with intraperitoneal injection streptozotocin (STZ). Renal epithelial cells (HK-2) control high-glucose (30 mmol/L), (40 mg/L, 20 10...
BACKGROUND:This study aimed to investigate the effects of hirudin on production extracellular matrix (ECM) factors by renal tubular epithelial cells in a rat model diabetic kidney disease (DKD) and HK-2 human tubule cells. MATERIAL AND METHODS:Sprague-Dawley rats were divided into normal control group (n=10), control+hirudin DKD (n=12) DKD+hirudin (n=12). At end study, histopathology was undertaken, expression type IV collagen, fibronectin, hypoxia-inducible factor-1α (HIF-1α), vascular...
Abstract Radiotherapy is an important adjuvant treatment for large intestine cancer even though it does not cause any response in many patients. The present study aimed to investigate the effects of TTN antisense RNA 1 (TTN‐AS1) long noncoding (lncRNA) on radiotherapy dynamics cells and explore underlying molecular mechanisms. TTN‐AS1 expression was evaluated by reverse‐transcription quantitative polymerase chain reaction, western blot, cellular immunofluorescence, flow cytometry analysis...
<b><i>Introduction:</i></b> Diabetic nephropathy (DN) is a common complication in diabetic patients. Chemerin, novel adipokine, has been associated with renal damage DN. The chemerin chemokine-like receptor 1 (CMKLR1) reported to participate In this study, we aimed investigate the effect of CMKLR1 antagonist, 2-(anaphthoyl)ethyltrimethylammonium iodide (α-NETA), on <b><i>Methods:</i></b> To induce diabetes, 8-week-old male C57BL/6J mice were...
To investigate the risk factors for human cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation in children and impact of on post-transplant immune reconstitution.