A5048783399- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Genetic and Kidney Cyst Diseases
- Renal cell carcinoma treatment
- Biomedical Research and Pathophysiology
- Renal and related cancers
- Ion Transport and Channel Regulation
- Vitamin D Research Studies
- Muscle and Compartmental Disorders
- Hedgehog Signaling Pathway Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune Response and Inflammation
- Pregnancy and preeclampsia studies
- Advanced Glycation End Products research
- Angiogenesis and VEGF in Cancer
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cerebrovascular and genetic disorders
- Inflammatory mediators and NSAID effects
- Inflammasome and immune disorders
- Drug-Induced Hepatotoxicity and Protection
- Ginkgo biloba and Cashew Applications
Shanghai University of Traditional Chinese Medicine
2023-2024
Shuguang Hospital
2023-2024
Guangzhou University
2010-2022
First Affiliated Hospital of Henan University
2020-2021
Henan University
2021
Henan Provincial People's Hospital
2020
Inflammation-induced podocyte apoptosis plays an important role in kidney injury during diabetic nephropathy (DN). Hirudin (HIR), a natural compound extracted from leeches, can inhibit inflammation. However, whether HIR protect the kidneys against inflammation DN is unknown. In present study, we aimed to study effects of on damage rat model and explore its anti-inflammatory properties.A streptozotocin-induced was generated, administered subcutaneously. Immortal podocytes primary peritoneal...
The study is aimed at investigating the effects of Ginkgo biloba extract EGB761 on renal tubular damage and endoplasmic reticulum stress (ERS) in diabetic kidney disease (DKD). A total 50 C57BL/6 N mice were randomly divided into normal group, DKD DKD+EGB761 group (36 mg/kg), DKD+4-phenylbutyrate (4-PBA) (1 g/kg). model was replicated by high-fat diet combined with intraperitoneal injection streptozotocin (STZ). Renal epithelial cells (HK-2) control high-glucose (30 mmol/L), (40 mg/L, 20 10...
BACKGROUND:This study aimed to investigate the effects of hirudin on production extracellular matrix (ECM) factors by renal tubular epithelial cells in a rat model diabetic kidney disease (DKD) and HK-2 human tubule cells. MATERIAL AND METHODS:Sprague-Dawley rats were divided into normal control group (n=10), control+hirudin DKD (n=12) DKD+hirudin (n=12). At end study, histopathology was undertaken, expression type IV collagen, fibronectin, hypoxia-inducible factor-1α (HIF-1α), vascular...
We aimed to investigate the preventive effect of high mobility group box 1 (HMGB1)-A and mechanism by which it alleviates inflammatory injury in acute liver failure (ALF) inhibiting extracellular release HMGB1. BALB/c mice were intraperitoneally (i.p.) administered LPS/D-GalN establish an ALF mouse model. HMGB1-A was h before establishing The levels extracellularly released HMGB1, TLR-4/NF-κB signaling molecules, proinflammatory cytokines TNF-α, IL-1β, IL-6 COX-2 measured tissue and/or serum...
Abstract Autosomal dominant polycystic kidney disease (ADPKD) is a life-long and caused by mutations in PKD1 or PKD2 gene. Fibrosis hallmark of chronic positively correlated with renal cyst growth, however the role fibrosis ADPKD still controversial. In this study, we established toxic surgical injuries adult mice, Pkd gene was inactivated at different time point before after injury according to pattern progression models. Here showed that inactivation can both induce cysts Pkd1 Pkd2 extent...
Abstract Background and Aims Acute kidney injury (AKI) is not a merely transient event, which can lead to subsequent progression chronic disease (CKD). Autosomal dominant polycystic (ADPKD) the most frequent inherited caused by mutations in PKD1 or PKD2 gene. Previous studies showed that acute injuries promote cystogenesis adult mice with ADPKD. Fibrosis hallmark of AKI CKD (AKI-CKD) transition, positively correlated renal cyst growth humans. All these data imply role AKI-CKD transition...
Abstract Mutations in PKD1 (encoding polycystin-1) or PKD2 polycystin-2) gene cause autosomal dominant polycystic kidney disease (ADPKD), however high levels of polycystins are detected renal tissues ADPKD patients. Animal studies showed that loss and gain function both pathogenic can induce cystic phenotype the kidney, which associated with enhanced fibrosis. Recent increased expression contributes to organ However, role tubulointerstitial fibrosis remains unclear. In this study, we...