A5101824070- Chronic Kidney Disease and Diabetes
- Renal Diseases and Glomerulopathies
- Muscle and Compartmental Disorders
- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Ocular Surface and Contact Lens
- Parathyroid Disorders and Treatments
- Cancer-related molecular mechanisms research
- Pregnancy and preeclampsia studies
- Dialysis and Renal Disease Management
- Sinusitis and nasal conditions
- Nasolacrimal Duct Obstruction Treatments
- RNA modifications and cancer
- Stroke Rehabilitation and Recovery
- Ginkgo biloba and Cashew Applications
- NF-κB Signaling Pathways
- MicroRNA in disease regulation
- Advanced Glycation End Products research
- Endoplasmic Reticulum Stress and Disease
- Iron Metabolism and Disorders
- Osteoarthritis Treatment and Mechanisms
- Inflammatory Myopathies and Dermatomyositis
- Inflammatory mediators and NSAID effects
- Cerebrovascular and genetic disorders
- Skin Diseases and Diabetes
Guangzhou Medical University
2024-2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2023
Henan University
2021
First Affiliated Hospital of Henan University
2018-2021
Henan Provincial People's Hospital
2020
Henan University of Traditional Chinese Medicine
2020
Inflammation-induced podocyte apoptosis plays an important role in kidney injury during diabetic nephropathy (DN). Hirudin (HIR), a natural compound extracted from leeches, can inhibit inflammation. However, whether HIR protect the kidneys against inflammation DN is unknown. In present study, we aimed to study effects of on damage rat model and explore its anti-inflammatory properties.A streptozotocin-induced was generated, administered subcutaneously. Immortal podocytes primary peritoneal...
Introduction Following spinal cord injury (SCI), blood-borne monocytes infiltrate the cord, differentiate into macrophages, and dominate lesion site. Inflammatory responses mediated by macrophages determine nerve regeneration functional recovery after SCI. Tauroursodeoxycholic acid (TUDCA) shows a neuroprotective effect in different SCI animal models. However, underlying mechanism of TUDCA regulating monocytes/macrophages to impact has not been elucidated clearly. This study aims investigate...
The study is aimed at investigating the effects of Ginkgo biloba extract EGB761 on renal tubular damage and endoplasmic reticulum stress (ERS) in diabetic kidney disease (DKD). A total 50 C57BL/6 N mice were randomly divided into normal group, DKD DKD+EGB761 group (36 mg/kg), DKD+4-phenylbutyrate (4-PBA) (1 g/kg). model was replicated by high-fat diet combined with intraperitoneal injection streptozotocin (STZ). Renal epithelial cells (HK-2) control high-glucose (30 mmol/L), (40 mg/L, 20 10...
BACKGROUND:This study aimed to investigate the effects of hirudin on production extracellular matrix (ECM) factors by renal tubular epithelial cells in a rat model diabetic kidney disease (DKD) and HK-2 human tubule cells. MATERIAL AND METHODS:Sprague-Dawley rats were divided into normal control group (n=10), control+hirudin DKD (n=12) DKD+hirudin (n=12). At end study, histopathology was undertaken, expression type IV collagen, fibronectin, hypoxia-inducible factor-1α (HIF-1α), vascular...
Abstract Osteoarthritis (OA) is a common chronic degenerative disease which characterized by the disruption of articular cartilage. Syringic acid (SA) phenolic compound with anti‐inflammatory, antioxidant, and other effects including promoting osteogenesis. However, effect SA on OA has not yet been reported. Therefore, purpose our study was to investigate mechanism in mouse model medial meniscal destabilization. The expressions genes were evaluated qPCR or western blot immunofluorescence....
Abstract Radiotherapy is an important adjuvant treatment for large intestine cancer even though it does not cause any response in many patients. The present study aimed to investigate the effects of TTN antisense RNA 1 (TTN‐AS1) long noncoding (lncRNA) on radiotherapy dynamics cells and explore underlying molecular mechanisms. TTN‐AS1 expression was evaluated by reverse‐transcription quantitative polymerase chain reaction, western blot, cellular immunofluorescence, flow cytometry analysis...
Abstract Background Peritoneal fibrosis is one of the major complications induced by peritoneal dialysis (PD). Damaged integrity and function peritoneum caused not only limits curative efficacy PD but affects prognosis patients. However, detailed mechanisms underlying process remain unclear therapeutic strategy targeting TGF‐β deficient. Transforming growth factor‐β (TGF‐β) signaling participates in progression through enhancing mesothelial-mesenchymal transition mesothelial cells. Methods...
Abstract Purpose The study aims to explore the proteomic profile and specific target proteins associated with muscle growth in response botulinum neurotoxin A (BoNT‐A) treatment, order improve spasticity management children cerebral palsy (CP). Experimental design total of 54 participants provided 60 plasma samples for analysis. Among them, six were sampled before after receiving their first BoNT‐A injection. In addition, 48 unrelated enrolled, among whom one group had never received...
Objective To investigate the efficacy of application Norton in nasal endoscopic dacryocystorhinostomy. Methods The data 100 eyes cases chronic dacryocystitis who received dacryocystorhinostomy from Dec.2012 to Dec.2017 were analyzed retrospectively. All divided into 2 groups randomly. The treatment group, 50 cases, treated with cotton slice cavity before operation, and control adrenaline operation. mucosa was contracted by placing slices twice, once per 5 minutes.in 10 minutes...