A5102775583- Cerebral Palsy and Movement Disorders
- Neonatal and fetal brain pathology
- Child Nutrition and Feeding Issues
- Nutrition and Health in Aging
- Mitochondrial Function and Pathology
- Spinal Cord Injury Research
- Myasthenia Gravis and Thymoma
- Infant Development and Preterm Care
- Botulinum Toxin and Related Neurological Disorders
- Stroke Rehabilitation and Recovery
- Transcranial Magnetic Stimulation Studies
- Family and Disability Support Research
- Parkinson's Disease and Spinal Disorders
- Mesenchymal stem cell research
- Cardiac Ischemia and Reperfusion
- Muscle activation and electromyography studies
- Pituitary Gland Disorders and Treatments
Guangzhou Medical University
2021-2024
Guangzhou Women and Children Medical Center
2024
Guangzhou Sport University
2022-2023
University of Colorado Denver
1990
Nutritional problems are common in children with cerebral palsy (CP), yet the relationship between nutritional status and severity of CP is unclear.To describe characteristics CP, to explore children.This multicentre cross-sectional study included China. Weight height were measured converted z-scores. Gross Motor Function Classification System (GMFCS), Eating Drinking Ability (EDACS), Subjective Global Assessment (SGNA), social life ability, blood indicators tested.All 1,151 participants...
Abstract Objective Hypoxic–ischemic brain injury in infants often leads to hemiplegic motor dysfunction. The mechanism of their dysfunction has been attributed deficiencies the transcription factor sex-determining region (SRY) box 2 (Sox2) or non–receptor-type tyrosine kinase Fyn (involved neuronal signal transduction), which causes a defect myelin formation. Constraint-induced movement therapy (CIMT) following cerebral hypoxia–ischemia may stimulate growth by regulating Sox2/Fyn, Ras...
Constraint-induced movement therapy (CIMT) combined with repetitive transcranial magnetic stimulation (rTMS) have shown great potential in improving function schoolchildren unilateral cerebral palsy attributed to perinatal stroke. However, the prospect of application preschool children (UCP) various brain disorders remains unclear. In this prospective, assessor-blinded, randomized controlled study, 40 UCP (aged 2.5-6 years) were receive 10 days CIMT active or sham rTMS. Assessments performed...
Transcranial direct current stimulation (tDCS) has shown a promising prospect in improving function and spasticity school-aged children with cerebral palsy, but little is known preschool children. The aim of this study was to explore the safety effects tDCS on hand (aged 3–6 years) hemiplegic palsy (HCP). We designed crossover, single-blind, sham-controlled 30 HCP, who were recruited receive one session sham active anodal (1.5 mA, 20 min) primary motor cortex affected hemisphere, 24-h...
To investigate the efficacy and safety of high-calorie formula vs. Chinese daily food on nutritional status motor function undernourished children with cerebral palsy (CP). In this prospective, assessor-blind, randomized controlled trial, we recruited (1-10 years) CP undernutrition based WHO American Society for Parenteral Enteral Nutrition criteria from National Children's Medical Center. Participants were randomly allocated (1:1) to a group or diet (control group) 6 months. Indirect...
To investigate the reproducibility, stability, internal consistency and ability to grade malnutrition of Subjective Global Nutritional Assessment (SGNA) in outpatient children with cerebral palsy.This was a part larger, cross-sectional study (ChiCTR2000033869) at tertiary hospital. The recruitment data collection Cerebral Palsy aged from 1 18 years were August 2020 March 2021. concurrent validity, inter-rater reliability, test-retest reliability SGNA tested. analyze data, specificity,...
The long-term effect of botulinum neurotoxin A (BoNT-A) on children with cerebral palsy (CP) is unclear, and how the dynamic changes metabolites impact duration remains unknown. To tackle this, we collected 120 plasma samples from 91 spastic CP for analysis, 30 in each time point: prior to injection 1, 3, 6 months after injection. total 354 were identified across all points, 39 which exhibited significant (with tentative IDs) (p values <0.05, VIP > 1). Principal component analysis partial...
ABSTRACT Importance Nutrition is associated with neurodevelopment. Infants at high risk of cerebral palsy (CP) usually suffer from undernutrition, yet the relationship between nutritional status and neurodevelopmental levels unclear. Objective To describe characteristics infants CP, to explore status. Methods This single‐center cross‐sectional study enrolled corrected age 0 days 12 months. Weight height were measured calculated into z‐scores, which used classify based on World Health...
Abstract Introduction: Cerebral palsy (CP) is the most common physical disability in children, which brings heavy economic and mental burden to families society. Nowadays, clinical management of CP faces with huge challenge due unsatisfactory therapeutic effects enormous heterogeneity etiology manifestations. This study aims investigate functional changes influential factors Chinese children CP, elucidate characteristic brain structure genetic etiology, thus provide solutions for prevention...
Abstract Purpose The study aims to explore the proteomic profile and specific target proteins associated with muscle growth in response botulinum neurotoxin A (BoNT‐A) treatment, order improve spasticity management children cerebral palsy (CP). Experimental design total of 54 participants provided 60 plasma samples for analysis. Among them, six were sampled before after receiving their first BoNT‐A injection. In addition, 48 unrelated enrolled, among whom one group had never received...
Background: Nutritional problems are common in children with cerebral palsy (CP), yet little is known about the relationship between severity of CP and their nutritional status.Methods: This multicenter cross-sectional study included China. Weight height were measured converted to z scores. Gross Motor Function Classification System (GMFCS), Eating Drinking Ability (EDACS), Subjective Global Assessment (SGNA) social life ability evaluated for all children, blood indicators tested 412...
Journal of the American Society Nephrology : JASN 1(6):p 927-928, December 1990. | DOI: 10.1681/ASN.V16927
Objective To evaluate the reliability and validity of 4 myasthenia gravis (MG) scales widely used for assessing grades disease severity in Chinese MG patients. Methods Sixty patients were examined by a neurologist with following four scales: Quantitative Myasthenia Gravis Score (QMGS), Composite (MGC), Myasthenic Muscle Scale (MMS), Absolute Relative (ARS-MG). The whole assessment process was videotaped. Activities Daily Living (MG-ADL) score acquired after examination. same within 24...
Objective To develop new scales on the severity of myasthenia gravis (MG) which are suitable for clinical practice in China. Methods A final version comprehensive scale was developed by item optimization from a preliminary established combination Delphi method and previous evaluation items source scales. With original quantitative data 60 MG patients, were selected basis interobserver test-retest reliability items, contributions internal consistency construct validity scale....