A5076699957- MicroRNA in disease regulation
- RNA modifications and cancer
- Ovarian cancer diagnosis and treatment
- Recycling and utilization of industrial and municipal waste in materials production
- Bauxite Residue and Utilization
- Histone Deacetylase Inhibitors Research
- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Cancer-related gene regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- T-cell and Retrovirus Studies
- Concrete and Cement Materials Research
- Telomeres, Telomerase, and Senescence
- Peptidase Inhibition and Analysis
- CRISPR and Genetic Engineering
- Acute Myeloid Leukemia Research
- RNA Research and Splicing
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
Guangxi University
2025
Hainan Maternal and Child Health Hospital
2013-2019
University of South China
2019
Wuxi People's Hospital
2018
Nanjing Medical University
2018
Xiangya Hospital Central South University
2015
Central South University
2015
MicroRNAs (miRNAs) play an important role in the tumorigenesis of ovarian cancer. Previously, we have reported dysregulation miR-203 cancer tissues. However, biological functions and molecular mechanisms remain unknown. Here, showed that expression was increased tissues compared with adjacent non-cancerous transcription inhibited by P53. Forced promoted cell growth migration, while depletion migration cells. In addition, metastasis cells vivo shorted survival nude mice. Mechanically,...
ABSTRACT This study presents an investigation into the challenge of alleviating heavy metal pollution while using red mud (RM) as industrial byproduct, focusing on its application in preparation geopolymers. Synthesis RM-ground granulated blast furnace slag (GGBS)-based geopolymer (RMG) and studied with particular attention to optimizing compressive strength through modifying key parameters: RM content, Na2SiO3 modulus, water-to-binder ratio. The immobilization metals, particularly lead (Pb)...
Retinoid-related orphan receptor alpha (RORα) is involved in tumor development. However, the mechanisms underlying RORα inhibiting epithelial-to-mesenchymal transition (EMT) and invasion are poorly understood gastric cancer (GC). This study revealed that decreased expression of associated with GC development, progression, prognosis. suppressed cell proliferation, EMT, cells through inhibition Wnt/β-catenin pathway. overexpression resulted Wnt1 increased interaction β-catenin, which could...
Overcoming senescence is a feature of ovarian cancer cells; however, the mechanisms underlying regulation in cells remain largely unknown. In this study, we found that ITPKA was downregulated samples, and lower expression correlated with poor survival. Overexpression inhibited anchorage-independent growth induced senescence. However, knockdown promoted Mechanistically, to interact MDM2, which stabilized P53, an essential regulator Moreover, negatively regulated by miR-203, microRNA has been...
Epithelial ovarian cancer is one of the most common and aggressive diseases among female reproductive organ malignancies, molecular mechanism underlying this disease remains largely unknown. EMSY, a binding partner BRCA2, has been reported to be amplified in cancer. However, expression pattern biological functions EMSY progression are not fully understood. In study, it was found that significantly elevated samples compared their adjacent normal tissues. Moreover, overexpression promoted...
The aim of the current study was to measure expression acetyl-N-Ser-Asp-Lys-Pro (ACSDKP) in patients with acute myeloid leukemia (AML) and effect prolyl oligopeptidase inhibitor (POPi) on bone marrow stromal cells these patients. Serum cell samples were collected from 33 AML admitted Wuxi Second People's Hospital, Nanjing Medical University between September 2011 August 2016. ACSDKP levels measured using a highly specific competitive enzyme immunoassay (EIA). Bone treated synthetic (10...