A5034494853- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
- RNA and protein synthesis mechanisms
- Diet, Metabolism, and Disease
- Immune Cell Function and Interaction
- Plant biochemistry and biosynthesis
- Cardiac Fibrosis and Remodeling
- Mesenchymal stem cell research
- Immunotherapy and Immune Responses
- Metabolism, Diabetes, and Cancer
- CAR-T cell therapy research
- IL-33, ST2, and ILC Pathways
- Cancer Risks and Factors
- Pluripotent Stem Cells Research
- Cancer Immunotherapy and Biomarkers
- Caveolin-1 and cellular processes
- Cholesterol and Lipid Metabolism
- Bariatric Surgery and Outcomes
- Breast Lesions and Carcinomas
- Molecular Biology Techniques and Applications
- Acne and Rosacea Treatments and Effects
- Phytochemical compounds biological activities
- Ferroptosis and cancer prognosis
- Photodynamic Therapy Research Studies
Central South University
2008-2025
Xiangya Hospital Central South University
2008-2025
Southwest Forestry University
2024
Anhui Medical University
2023-2024
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
Deyang Stomatological Hospital
2024
First Affiliated Hospital of Jinan University
2015-2023
Bristol-Myers Squibb (United States)
2018-2023
Nanjing Drum Tower Hospital
2018-2023
This report describes an unbiased method for systematically determining gene function in mammalian cells. A total of 20,704 predicted human full-length cDNAs were tested induction the IL-8 promoter. number genes, including those cytokines, receptors, adapters, kinases, and transcription factors, identified that induced promoter through known regulatory sites. Proteins acted a cooperative interaction between AP-1 unrecognized cAMP response element (CRE)-like site also identified. protein,...
Agents targeting the PD1-PDL1 axis have transformed cancer therapy. Factors that influence clinical response to inhibitors include tumor mutational burden, immune infiltration of tumor, and local PDL1 expression. To identify peripheral correlates anti-tumor in absence checkpoint blockade, we performed a retrospective study circulating T cell subpopulations matched gene expression melanoma non-small lung (NSCLC) patients. Notably, both NSCLC patients whose tumors exhibited increased...
Pathogenic factors driving obesity to type 2 diabetes (T2D) are not fully understood. Group 1 innate lymphoid cells (ILC1s) effectors of immunity and enriched in inflamed tissues. Here we show that the number adipose ILC1s increases obese T2D patients correlates with glycemic parameters blood; circulating ILC1 numbers decrease as a result metabolic improvements after bariatric surgery. In vitro co-culture experiments human promote fibrogenesis CD11c+ macrophage activation. Reconstruction...
ABSTRACT We have developed an antisense oligonucleotide microarray for the study of gene expression and regulation in Bacillus subtilis by using Affymetrix technology. Quality control tests B. GeneChip were performed to ascertain quality array. These included optimization labeling hybridization conditions, determination linear dynamic range levels, assessment differential patterns known vitamin biosynthetic genes. In minimal medium, we detected transcripts approximately 70% open reading...
An increasing number of high-risk patients with coronary heart disease (similar to acute myocardial infarction (AMI)) are using PCSK9 inhibitors. However, whether affects repair and the molecular mechanism modulation immune inflammation after AMI not known. The present research investigated role in immunomodulation macrophages provided evidence for clinical application inhibitors improve cardiac repair.Wild-type C57BL6/J (WT) PCSK9-/- mouse hearts were subjected left anterior descending...
A Xenopus oocyte expression library was screened for proteins that bind to the 340-nucleotide localization element of Vg1 mRNA. Four different isolates encoded a homolog human transcription factor,FUSE-binding protein 2 (FBP2). This has been independently identified as splicing regulatory factor KSRP. The only significant difference between protein, designated VgRBP71, and KSRP is absence 58 amino acid segment near N-terminal former. In vivo binding assays show VgRBP71 associated with mRNAs...
The nuclear factor kappaB (NF-κB) subunit p65, plays an important role in the progression of hepatocellular carcinoma (HCC). Phosphorylation p65 is considered as mechanism for positive regulation NF-κB activity. According to our previous data, can be SUMOylated by small ubiquitin-related modifier 1 (SUMO1) protein, and SUMO1 promotes import HCC progression. However, effect SUMO1-related SUMOylation on transcriptional activity relationship between phosphorylation remain obscure. Here, we...
Abstract Aim To assess metabolic effects and safety of Roux‐en‐Y gastric bypass (RYGB) versus conventional medication (CM) in obese Chinese patients with type 2 diabetes (T2DM). Methods This retrospective cohort study included 40 who underwent RYGB (mean age 44.1 years, body mass index [BMI] 33.3 kg/m ) 36 administered CM 49.4 BMI 32.1 ). The primary endpoint was achievement the triple (haemoglobin A1C [HbA1c] < 7.0%, low‐density lipoprotein cholesterol 2.6 mmol/L, systolic blood pressure...
Increasing the frequency of blood glucose monitoring aids evaluation glycemic variability and control by antidiabetic drugs. It remains unclear, however, whether GLP-1 receptor agonists or basal insulin has a better effect on in type 2 diabetes mellitus (T2DM) patients who are inadequately controlled metformin. We used continuous system (CGMS) to compare agonist with terms variability. This prospective randomized study assigned T2DM treated metformin (N = 39) either exenatide treatment...
Immune cell expression profiling from patient samples is critical for the successful development of immuno-oncology agents and useful to understand mechanism-of-action, identify exploratory biomarkers predictive response, guide treatment selection combination therapy strategies. LAG-3 an inhibitory immune checkpoint that can suppress antitumor T-cell responses targeting LAG-3, in with PD-1, a rational approach enhance immunity has recently demonstrated clinical success. Here, we sought human...
Weight loss, especially fat mass reduction, helps to improve blood glucose control, insulin sensitivity, and β-cell function. This study aimed compare the effect of exenatide glargine on body composition in overweight obese patients with type 2 diabetes (T2DM) who do not achieve adequate glycemic control metformin. We performed a prospective, randomized 37 or T2DM had inadequate The were treated either for 16 weeks. Dual-energy X-ray absorptiometry was used assess composition....
Photodynamic therapy with topical aminolevulinic acid (ALA-PDT) has been suggested to be effective in treatment of acne vulgaris. However, adverse events occur during and after treatment.To compare the efficacy tolerability optical intra-tissue fiber irradiation (OFI) ALA-PDT versus traditional vulgaris rabbit models.Twenty-five rabbits clean grade were used. Twenty randomly selected establish model other five used as control. Rabbits group (40 ears) further divided into four groups (10...
Background The relationship between anxiety, depression, and metabolic parameters the incidence of breast nodules is unclear. This study aims to investigate association female depression factors. Methods cross-sectional recruited 857 individuals with biological indicators ultrasound data from Daping hospital April 2021 February 2022. Serum samples were used measure fasting blood glucose, uric acid, triglycerides, total cholesterol, urea nitrogen, alanine transaminase, aspartate albumin,...
A significant number of women who undergo neuraxial labor analgesia experience breakthrough pain. Prompt mitigation pain is essential to improve maternal and fetal outcomes. We evaluated epidural chloroprocaine compared with ropivacaine in alleviating performed a double-blind randomized controlled clinical trial between May July 2023. Eligible parturients received sufentanil. Those were receive either 0.125% (group R) or at concentrations 0.5% C1), 1.0% C2), 1.5% C3), all volume 6 mL. The...
Docynia delavayi is an economically significant fruit species with a high market potential due to the special aroma of its fruit. Here, 653.34 Mb high-quality genome D. was first reported, which 93.8% sequences were assembled 17 chromosomes. A total 48325 protein-coding genes annotated in genome. Ks analysis proved that two whole duplication (WGD) events occurred delavayi, resulting expansion associated terpene biosynthesis, promoted fruit-specific production. Combined multi-omics analysis,...