A5054788652- Diabetes and associated disorders
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
- Cell death mechanisms and regulation
- Blood Pressure and Hypertension Studies
- Renal Transplantation Outcomes and Treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Heart Rate Variability and Autonomic Control
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- COVID-19 Clinical Research Studies
- Dialysis and Renal Disease Management
- NF-κB Signaling Pathways
- interferon and immune responses
- Receptor Mechanisms and Signaling
- Computational Drug Discovery Methods
- Immunodeficiency and Autoimmune Disorders
- Organ and Tissue Transplantation Research
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Animal Virus Infections Studies
- Monoclonal and Polyclonal Antibodies Research
- Advanced Biosensing Techniques and Applications
Hadassah Medical Center
2013-2023
Hebrew University of Jerusalem
2021-2023
Israel Ministry of Health
2013
Hadassah Academic College
2004
University of Pennsylvania
2003
Abstract CD47 is a cell surface ligand expressed on all nucleated cells. It unique immune checkpoint protein acting as “don’t eat me” signal to prevent phagocytosis and constitutively overexpressed in many tumors. However, the underlying mechanism(s) for overexpression not clear. Here, we show that irradiation (IR) well various other genotoxic agents induce elevated expression of CD47. This upregulation correlates with extent residual double-strand breaks (DSBs) determined by γH2AX staining....
Abstract The APC:T cell interface can be effectively targeted with immunotherapeutic proteins. We previously described a unique trans signal converter protein, CTLA-4 · Fas ligand (FasL), that has the inherent capacities to tether T inhibitor FasL (CD95 ligand) surfaces of B7 (CD80 and CD86)-positive APC (via CTLA-4:B7 interaction), in so doing, simultaneously interfere B7-to-CD28 activation signals. Given continuing need for agents capable inducing allograft tolerance without generalized...
New strategies for the treatment of hepatocellular carcinoma (HCC) are needed, given that currently available chemotherapeutics inefficient. Since tumor growth reflects net balance between pro-proliferative and death signaling, agents shifting equilibrium toward latter considerable interest. The TWEAK:Fn14 signaling axis promotes cell proliferation angiogenesis, while TRAIL:TRAIL-receptor (TRAIL-R) interactions selectively induce apoptosis in malignant cells. Fn14•TRAIL, a fusion protein...
Non-Hodgkin lymphomas (NHLs) account for 4% of all malignancies. 5-year survival rate increased to 50% with new treatment modalities, however there is need effective the more aggressive, relapsing forms. Recently, CTLA4-FasL, that can bind B7 and Fas receptor (Fas), was shown induce robust apoptosis cell lines originating from B expressing both Fas, by activating pro-apoptotic signals in parallel abrogating anti-apoptotic ones. The present study focuses on unique properties CTLA4-FasL as a...
Access-related infections are a major cause of morbidity and mortality in haemodialysis patients. Our goal was to decrease the rate these by implementing an intervention surveillance program. This took place two units (Units A B) joint effort staff unit for infection prevention control. It included reviewing work methods space, observations on compliance with standard precautions handling vascular access, creating checklist designated kit access prospective access-related infections. During...
In 2013 the Israeli Ministry of Health appointed a public committee to examine policy placing an age limitation on candidates listed for organ transplantation. The rejected use limit criterion listing transplantation and recommended abolish it. However, opinions differed regarding recipients’ in shaping fair allocation policy. committee's recommendations were adopted put into force as April 2014. This article unfolds deliberations accommodating values formal equality optimising
A patient presented with fever, haemoptysis and large bilateral perihilar masses. Histology proved that these were pulmonary artery aneurysms due to vasculitis, as a manifestation of Behcet's disease. It is suggested routine dynamic computed tomographic (CT) scan should be performed in the evaluation such cases.
BackgroundContinuous systolic blood pressure (SBP) and interbeat intervals (IBI) recordings reveal sequences of consecutive beats in which SBP heart rate change opposite direction, representing negative feedback baroreflex mechanisms, as well the same direction (non-baroreflex), believed to represent feedforward control mechanisms. The present study was undertaken assess relationship between non-baroreflex end stage renal insufficiency. Methodology/Principal FindingsContinuous beat-to-beat...
Abstract Background Determining the humoral immunogenicity of tozinameran (BNT162b2) vaccine in patients requiring chronic renal replacement therapy, and its impact on COVID-19 morbidity several months after vaccination, will guide risk assessment subsequent changes vaccination policy. Methods In a prospective post-vaccination cohort study with up to 5 follow-up we studied outpatient dialysis kidney transplant respective healthcare teams. Outcomes were anti S1/S2 antibody response or...
Abstract Cytotoxic T-lymphocyte antigen 4 (CTLA4)-FasL, a homo-hexameric signal converter protein, is capable of inducing robust apoptosis in malignant cells the B-cell lineage expressing its cognate B7 and Fas targets, while sparing nonmalignant ones. This fusion protein's striking proapoptotic efficacy stems from complementary abilities to coordinately activate apoptotic signals abrogate antiapoptotic A limiting factor translating FasL or receptor agonists into clinic has been lethal...
Cardiovascular disease is a leading cause of death among kidney transplant recipients. Metabolic syndrome increases the risk for cardiovascular events and decreases graft survival. Lately, guidelines management metabolic syndrome, primarily hypertension, diabetes mellitus (DM) hypercholesterolemia have dramatically changed in an attempt to decrease risks In present study we examined whether these guideline changes had impact on our post-transplantation patients subsequent treatment outcomes...
Abstract Background Patients needing chronic RRT are at risk for severe COVID-19 and mount a lesser response to mRNA vaccination. We describe the impact of booster administration in these patients, amidst third wave infections deaths. Methods In setting prospective COVID-19-centred cohort study dialysis kidney transplant patients we examined humoral responses vaccination, subsequent infection risk. Results quantified antibodies (DiaSorin) 198 maintenance 314 82 controls, without prior...
<p>Elevation of pro-inflammatory cytokines in CTLA4-FasL treated mice was prevented by dexamethasone</p>
<p>Transient changes in blood counts CTLA4-FasL treated mice were prevented by dexamethasone</p>
<p>Elevation of pro-inflammatory cytokines in CTLA4-FasL treated mice was prevented by dexamethasone</p>