A5017020888- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Hepatitis C virus research
- Bone Metabolism and Diseases
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Listeria monocytogenes in Food Safety
- Diagnosis and treatment of tuberculosis
- Amoebic Infections and Treatments
- Nail Diseases and Treatments
- Food Safety and Hygiene
- Trace Elements in Health
- Liver Disease Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Actinomycetales infections and treatment
- Autoimmune and Inflammatory Disorders
- Infectious Diseases and Mycology
- Sex work and related issues
- Diabetes and associated disorders
- Bone health and treatments
Hebrew University of Jerusalem
2004-2025
Hadassah Medical Center
2016-2025
Kaplan Medical Center
2024
Herzog Hospital
2018-2022
Weatherford College
2021
University Medical Center
2011-2020
Merck & Co., Inc., Rahway, NJ, USA (United States)
2017
Yale University
2012
Hadassah Academic College
2001-2004
Listeria monocytogenes is a foodborne pathogen that causes life-threatening infections in elderly, immunocompromised, and pregnant women. In pregnancy it may cause fetal loss or preterm delivery, the neonate prone to neonatal sepsis death.We created cohort of all L. cases during 10 years (1998-2007) Israel, by comprehensive review hospitals throughout country reported Ministry Health.One hundred sixty-six pregnancy-related listeriosis were identified, resulting yearly incidence 5-25 per 100...
Intramuscularly administered vaccines stimulate robust serum neutralizing antibodies, yet they are often less competent in eliciting sustainable “sterilizing immunity” at the mucosal level. Our study uncovers a strong temporary component of immunity, emanating from intramuscular administration an mRNA vaccine. We show that saliva BNT162b2 vaccinees contains IgA targeting receptor-binding domain (RBD) severe acute respiratory syndrome coronavirus-2 spike protein and demonstrate these IgAs...
Dermatophytes are common pathogens of skin but rarely cause invasive disease. We present a case deep infection by Trichophyton rubrum in an immunocompromised patient. T. was identified morphological characteristics and confirmed PCR. Invasiveness apparent histopathology immunohistochemistry. The patient treated successfully with itraconazole.
Abstract Objective This study aimed to assess weight gain associated with treatment switching INSTI-based regimens in people living HIV (PLWH) and determine whether it is accompanied by worsening features of hypertension, dyslipidemia, or hyperglycemia. Methods In this two-center retrospective observational study, we assessed metabolic PLWH who switched an regimen (study group) as compared patients remained on a non-INSTI (control over 24-month follow-up period. Results One-hundred...
Objective: Assess virological failures, analyze the results of resistance testing (RET), and investigate factors associated with acquired drug mutations (aDRM). Design: A retrospective longitudinal cohort study. Methods: Virological failures (viral load >50 copies/ml) from a 1130 individuals, diagnosed HIV-1 in 2010–2018 followed up until 2020, were included. Demographic, clinical, data collected. piecewise exponential additive mixed model was employed to estimate association various...
Parkinsonism-hyperpyrexia syndrome (PHS) is a neurologic potentially fatal emergency that mimics neuroleptic malignant syndrome. It commonly presents as systemic inflammatory response syndrome, acute onset worsening of muscular rigidity, autonomic instability, hyperpyrexia, confusion, diaphoresis and high creatine phosphokinase. The most common trigger for PHS reduction or withdrawal anti-Parkinson’s medications, especially levodopa. was also reported in few cases following deep brain...
Diabetic foot infections (DFIs) are frequently polymicrobial, yet the relevance of each isolated pathogen, remains ill-defined. Specifically, prevalence and pathogenicity enterococcal DFIs impact targeted antienterococcal treatment remain elusive.We collected demographic, clinical, outcome-related data on patients admitted with to Hadassah Medical Center diabetic unit between 2014 2019. The primary outcome was a composite in-hospital death or major amputation. Secondary outcomes included any...
Despite the low prevalence of HIV-1 in Israel, continuous waves immigration may have impacted local epidemic. We characterized all people diagnosed with Israel 2010–2018. The demographics and clinical data individuals (n = 3639) newly were retrieved. Subtypes, transmitted drug-resistance mutations (TDRM), phylogenetic relations, determined >50% them. In 39.1%, transmission was through heterosexual contact; 34.3% men who sex (MSM); 10.4% inject drugs. Many (>65%) immigrants....
ABSTRACT Scytalidium dimidiatum , a dematiaceous fungus, has been well established as an agent of dermatomycosis. There are few reports invasive infection caused by S. ; most infections occurred in immunocompromised hosts. We present immunocompetent patient with pleural and review nine other published cases infections.
Bariatric surgery is increasingly performed in morbidly obese HIV patients. Limited data exist regarding antiretroviral drug exposure after bariatric surgery. We report a case of patient who underwent sleeve gastrectomy. Abacavir, lamivudine, and dolutegravir therapeutic monitoring was at several time points pre- postsurgery. Significantly increased levels were measured, particularly for abacavir, whose ∼12-fold. Several mechanistic explanations these findings are discussed.
The association between Body Mass Index (BMI) and clinical outcomes following sepsis continues to be debated. We aimed investigate the relationship BMI in-hospital course mortality in patients hospitalized with bacteremic using real-world data. A sampled cohort of October 2015 December 2016 was identified National Inpatient Sample (NIS) database. In-hospital length stay were defined as relevant outcomes. Patients divided into 6 (kg/m2) subgroups; (1) underweight ≤ 19, (2) normal-weight...
Productive replication of human immunodeficiency virus type 1 (HIV-1) occurs efficiently only in humans. The posttranscriptional stages the HIV-1 life cycle proceed poorly mouse cells, with a resulting defect viral assembly and release. Previous work has shown that presence chromosome 2 increases production cells. Recent studies have region maintenance (hCRM1) stimulates Gag release from rodent Here we report expressions hCRM1 murine cells resulted marked infectious feline (FIV). was also...
Background: Direct comparisons between countries in core HIV care parameters are often hampered by differences data collection. Aim: Within the EuroSIDA study, we compared levels of antiretroviral treatment (ART) coverage and virological suppression (HIV RNA < 500 copies/mL) across Europe explored temporal trends. Methods: In three cross-sectional analyses 2004–05, 2009–10 2014–15, assessed country-specific percentages ART among those on ART. Temporal changes were analysed using logistic...
Background HIV in Israel started with a subtype-B epidemic among men who have sex men, followed the 1980s and 1990s by introductions of subtype C from Ethiopia (predominantly acquired heterosexual transmission) A former Soviet Union (FSU, most often intravenous drug use). The matured over last 15 years without additional large influx exogenous infections. Between 2005 2013 number infected (MSM) increased 2.9-fold, compared to 1.6-fold 1.3-fold for users (IVDU) Ethiopian-origin residents....
Diabetes mellitus (DM) is more common among people living with human immunodeficiency virus (PLWH) compared healthy individuals. In a prospective multicenter study (N = 248), we identified normoglycemic (48.7%), prediabetic (44.4%), and diabetic (6.9%) PLWH. Glycosylated hemoglobin (HbA1c) fasting blood glucose (FBG) sensitivity in defining dysglycemia was 96.8%, while addition of oral tolerance test led to reclassification only 4 patients. Inclusion 93 additional PLWH known DM enabled...