A5027652197- Cardiac Valve Diseases and Treatments
- Chemokine receptors and signaling
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Cardiac and Coronary Surgery Techniques
- Anesthesia and Neurotoxicity Research
- Cytokine Signaling Pathways and Interactions
- Neuroblastoma Research and Treatments
- Infective Endocarditis Diagnosis and Management
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Aortic aneurysm repair treatments
- Signaling Pathways in Disease
- Cancer-related gene regulation
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Coronary Artery Anomalies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Hebrew University of Jerusalem
2003-2024
Hadassah Medical Center
2006-2024
Al-Quds University
2024
Hadassah Academic College
2003-2021
University Medical Center
2010
Mayo Clinic
1999-2001
Abstract DNA methylation is a fundamental epigenetic mark that governs gene expression and chromatin organization, thus providing window into cellular identity developmental processes 1 . Current datasets typically include only fraction of sites are often based either on cell lines underwent massive changes in culture or tissues containing unspecified mixtures cells 2–5 Here we describe human methylome atlas, deep whole-genome bisulfite sequencing, allowing fragment-level analysis across...
The nasal mucosa constitutes the primary entry site for respiratory viruses, including severe acute syndrome coronavirus 2 (SARS-CoV-2). While imbalanced innate immune response of end-stage disease 2019 (COVID-19) has been extensively studied, earliest stages SARS-CoV-2 infection at mucosal have remained unexplored. Here, we employed and influenza virus in native multi-cell-type human turbinate lung tissues
Coarctation of the aorta is commonly associated with recoarctation or additional cardiovascular disorders that require intervention. The best surgical approach in such patients uncertain. Ascending-to-descending aortic bypass graft via posterior pericardium (CoA bypass) allows simultaneous intracardiac repair an alternative for patient complex coarctation.Between 1985 and 2000, 18 (13 males 5 females, mean age 43+/-13 years) coarctation underwent CoA through median sternotomy. Before...
Objectives Autocrine and paracrine chemokine/chemokine receptor-based interactions promote non-small-cell-lung-cancer (NSCLC) carcinogenesis. CCL20/CCR6 are involved in prostatic colonic malignancy pathogenesis. The expression function of its related Th-17 type immune response NSCLC is not yet defined. We sought to characterize the role CCL20/CCR6/IL-17 axis tumor growth. Methods A specialized histopathologist blindly assessed levels 49 tissue samples patients operated our department....
Abstract Mediastinal paraganglioms are rare, highly vascularized tumors arising from chromaffin tissue located in the para-aortic ganglia. Tumors tend to invade bordering structures and may also form metastasis. Up 50% of patients asymptomatic diagnosis is incidental. Presenting symptoms related catecholamine hypersecretion or a mass effect. Complete surgical resection remains standard care due malignant potential tumor poor response chemotherapy radiation. Strategic location proximity great...
Ischemia on thallium scanning is a strong predictor of long-term mortality in CAD patients. Whether coronary revascularization (CR) patients with significant ischemia preoperative (PTS) improves survival after major vascular surgery has not been determined.The perioperative data, including PTS and subsequent CR moderate to severe reversible PTS, 502 consecutive who underwent 578 procedures were analyzed retrospectively. Patients ultimately did undergo the planned operation also studied. Cox...
The chemokine receptor CXCR4 is involved in the growth and metastasis of tumor cells. However, expression its ligand, CXCL12, tumors role regulating accumulation immune cells within not clear. Using ELISA immunohistochemistry we found that CXCL12 expressed majority nonsmall cell lung cancer tissue sections obtained from stage IA to IIB patients undergoing operation. Histopathologic examination these indicated high correlated with increased inflammation. In addition, disease recurrence rates...
Abstract DNA methylation is a fundamental epigenetic mark that governs chromatin organization, cell identity, and gene expression. Here we describe human methylome atlas, based on deep whole-genome bisulfite sequencing allowing fragment-level analysis across thousands of unique markers for 39 types sorted from 207 healthy tissue samples. Replicates the same cell-type are >99.5% identical, demonstrating robustness identity programs to genetic variation environmental perturbation....
Insulin and insulin-like growth factor-I (IGF-I) are endogenous peptides with vasoactive activities.To evaluate the vasodilatory effects of insulin IGF-I on human vessels taken from patients without noninsulin-dependent diabetes mellitus (NIDDM) to elucidate their mechanisms action.Vascular rings internal mammary artery (IMA) saphenous vein harvested 54 NIDDM undergoing coronary bypass surgery were studied in vitro.For samples both (10(-12)-10(-7) mol/l) evoked greater relaxation IMA (30 +/-...
Traumatic rupture of the diaphragm is no longer uncommon. Because increasing frequency motor vehicle accidents, rate blunt trauma to chest and abdomen, which are most common causes diaphragmatic rupture, increased as well. However, diagnosis frequently missed or delayed because lack sensitivity specificity imaging modalities. Diagnostic laparoscopy considered a standard tool for penetrating injuries left widely practiced in selected cases. Right tears, however, more difficult diagnose...
Background: The worldwide escalation in the volume of suicide terrorist bombing attacks warrants special attention to specific pattern injury associated with such attacks. goal this study was characterize thoracic injuries inflicted by terrorist-related explosions and compare penetrating blunt trauma. Methods: Prospectively collected database patients chest who were admitted Hadassah Hospital Level I trauma centre, Jerusalem, Israel, from October 2000 December 2005. Patients divided into...
ABSTRACT Scytalidium dimidiatum , a dematiaceous fungus, has been well established as an agent of dermatomycosis. There are few reports invasive infection caused by S. ; most infections occurred in immunocompromised hosts. We present immunocompetent patient with pleural and review nine other published cases infections.
Advanced melanoma cells, characterized by resistance to chemotherapy, have been shown be highly sensitive oncolysis Newcastle disease virus (NDV). In the present study, we investigated capacity of NDV specifically infect and spread into solid tissues human lung carcinoma, in vivo ex . For this purpose a new model SCID-beige mice implanted with was developed. Surprisingly, replication competent NDV-MTH attenuated, single-cycle NDV-HUJ strains, demonstrated similar oncolytic activity...
Primary cardiac sarcomas are extremely rare, but aggressive, tumours. The median survival with conventional treatment is 6–12 months. Recent data suggest that a radical multidisciplinary approach may improve patient outcome. We sought to evaluate our institutional experience these A tumour programme was established 3 years ago based on the and support of collaborating institution. Treatment consisted pre- postoperative chemotherapy, complete (R0) resection structural reconstruction radiation...
Lymphocytic interstitial pneumonia (LIP) is a rare form of lung disease. A few case reports have described an association with common variable immunodeficiency (CVID). Corticosteroids are usually used to treat symptomatic patients but their efficacy has never been studied in controlled trial. We describe patient LIP and CVID who was treated monthly intravenous immunoglobulins (IVIG) without steroids. The improved dramatically. believe that, selected cases immunodeficiency, IVIG given should...
Background and objectives: A high rate of glycolysis may reflect the inflammatory activity interstitial lung disease (ILD). This prospective study investigated whether PET can distinguish IPF, a primarily fibrotic process, from other entities ILD that have marked component. Methods: Twenty‐one patients referred for surgical biopsy because diffuse underwent at time biopsy. transmission scans were obtained after injecting 18 FDG intravenously. Regions interest (ROI) drawn on images,...