A5084883109- Esophageal and GI Pathology
- Hernia repair and management
- Pelvic and Acetabular Injuries
- Gastric Cancer Management and Outcomes
- Ultrasound in Clinical Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal Tumor Research and Treatment
- Abdominal Surgery and Complications
- Hip and Femur Fractures
- Diverticular Disease and Complications
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Phagocytosis and Immune Regulation
- Electrospun Nanofibers in Biomedical Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Global Health and Surgery
- Anodic Oxide Films and Nanostructures
- Gastroesophageal reflux and treatments
- Renal and related cancers
- Helicobacter pylori-related gastroenterology studies
- Chemokine receptors and signaling
- Cardiovascular and Diving-Related Complications
- Cardiovascular Syncope and Autonomic Disorders
- Hereditary Neurological Disorders
- Metastasis and carcinoma case studies
Hadassah Medical Center
2017-2024
Hadassah Academic College
2011-2024
Royal London Hospital
2024
University College London
2024
Hebrew University of Jerusalem
2022-2023
Centre Hospitalier Universitaire de Lille
2022
Hôpital Claude Huriez
2022
Objective Cellular senescence limits tumourigenesis by blocking the proliferation of premalignant cells. Additionally, however, senescent cells can exert paracrine effects influencing tumour growth. Senescent are present in pancreatic intraepithelial neoplasia (PanIN) lesions, yet their on disease poorly characterised. It is currently unknown whether senolytic drugs, aimed at eliminating from could be beneficial development. Design To uncover functions and potential contribution to early...
Objectives Autocrine and paracrine chemokine/chemokine receptor-based interactions promote non-small-cell-lung-cancer (NSCLC) carcinogenesis. CCL20/CCR6 are involved in prostatic colonic malignancy pathogenesis. The expression function of its related Th-17 type immune response NSCLC is not yet defined. We sought to characterize the role CCL20/CCR6/IL-17 axis tumor growth. Methods A specialized histopathologist blindly assessed levels 49 tissue samples patients operated our department....
Optimal clinical outcomes in cancer treatments could be achieved through the development of reliable, precise ex vivo tumor models that function as drug screening platforms for patient-targeted therapies. Microfluidic tumor-on-chip technology is emerging a preferred tool since it enables complex set-ups and recapitulation physiologically relevant physical microenvironment tumors. In order to overcome common hindrances encountered while using this technology, fully 3D-printed device was...
Sarcoma classification is challenging and can lead to treatment delays. Previous studies used DNA aberrations machine-learning classifiers based on methylation profiles for diagnosis. We aimed classify sarcomas by analyzing signatures obtained from low-coverage whole-genome sequencing, which also identifies copy-number alterations. was extracted 23 suspected sarcoma samples sequenced an Oxford Nanopore sequencer. The methylation-based classifier, applied in the nanoDx pipeline, customized...
Medical professionalism refers to attributes, values, behaviors, responsibilities and commitments of physicians that are congruent with the public’s expectations. An international workshop on medical took place at Dead Sea, Israel, December 11–12, 2016. The meeting brought together local professionals, others, as well experts, discuss definitions wrestle current challenges facing profession including its perceived status physician satisfaction, unprofessional behavior relation health care...
Abstract Background Giant inguinal hernia (GIH) is a rare condition in the developed world, and literature scarce. Case reports describe different techniques an attempt to prevent abdominal compartment syndrome (ACS). We aimed review our experience with GIH repair. Method A retrospective of medical records all consecutive patients who underwent tension-free mesh repair using transverse incision between 2014 2021 at tertiary university referral center. In brief, technique included head-down...
BACKGROUND:Behcet’s disease (BD) is defined as vasculitis involving arteries and veins of any size affecting almost organ system. Abdominal manifestations BD are diverse nonspecific. Mucosal ulcerations can be seen in the gastrointestinal tract. Extensive ulcerations, especially ileocecal lesions, lead to perforation, strictures, fistulas, abscesses. Pneumatosis cystoides intestinale a rare benign condition characterized by multiple submucosal or subserosal, gas-filled cysts tract wall. coli...
Pathological diagnosis of sarcoma is based on histopathological features and immunohistochemical staining, as well fluorescence in situ hybridization (FISH), Sanger sequencing, massively parallel DNA methylation-based arrays. With this approach, up to 80–85% cases are classified. Nanopore sequencing a rapid, point care method for characterizing tumors' molecular landscape including single nucleotide variations, copy number alterations (CNA), translocations methylation. Using low coverage...
Familial dysautonomia (FD) is a genetic disease of the autonomous and sensory nervous systems. Severe gastro-oesophageal reflux common one major complications. Some patients with FD develop megaoesophagus. Oesophageal malfunction, accompanied by oesophageal food secretion retention, results in recurrent aspiration other severe respiratory Through traditional case report, we wish to show how reverse tubing oesophagus can lead significant symptomatic improvement these patients. Moreover, this...
Hypercoagulability after trauma is a known entity. Following significant trauma, most guidelines advise anticoagulation treatment for venous thromboembolism (VTE) prophylaxis. VTE following minor convoyed with arterial or systemic embolization dictate the need to search uncommon source of thromboembolic complications. This report an unusual case pulmonary and emboli complicated by splenic abscess in patient Diabetes Mellitus as first presentation patent foramen ovale (PFO).
Objective: To describe the management of pathogenic CDH1 variant carriers (pCDH1vc) within FREGAT (FRench Eso-GAsTric tumor) network. Primary objective focused on clinical outcomes and pathological findings, Secondary was to identify risk factor predicting postoperative morbidity (POM). Background: Prophylactic total gastrectomy (PTG) remains recommended option for gastric cancer in pCDH1vc with, however, endoscopic surveillance as an alternative. Methods: A retrospective observational...
Results A 20 y/o boy suffering from familial dysautonomia (FD) has been referred to the clinic due chronic cough, dyspnea, and desaturation secondary recurrent aspirations of esophageal content. He developed a megaesophagus, severe food secretion retention, leading pneumonia, cardiac compression on cross-sectional imaging exertional dyspnea. The patient was obliged manually remove secretions, using his own fingers. As rescue therapy, we replaced existing gastrostomy tube with...
Abstract Background Giant inguinal hernia (GIH), defined as a descending below the inner-thigh midpoint in upright position, is rare. Case reports describe techniques which abdominal cavity prepared and care taken to prevent compartment syndrome (ACS). Our aim was analyze review our experience with GIH repair. Methods Retrospective single-institution, case-control, study included adults who underwent repair between 2014–2021 at an university referral center. Technique endo-tracheal...