A5029831792- Bladder and Urothelial Cancer Treatments
- Kidney Stones and Urolithiasis Treatments
- Urinary and Genital Oncology Studies
- Pediatric Urology and Nephrology Studies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urinary Bladder and Prostate Research
- Radiation Dose and Imaging
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- Ureteral procedures and complications
- Urological Disorders and Treatments
- Infectious Disease Case Reports and Treatments
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Traumatic Ocular and Foreign Body Injuries
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Testicular diseases and treatments
- Paleopathology and ancient diseases
- Renal and Vascular Pathologies
- Abdominal Surgery and Complications
- Urologic and reproductive health conditions
- RNA modifications and cancer
Hebrew University of Jerusalem
2014-2025
Hadassah Medical Center
2013-2025
Hadassah Academic College
2003-2021
Western University
2011-2014
Université de Montréal
2013
Victoria Hospital
2011
Weatherford College
2011
Marymount University
2011
London Health Sciences Centre
2011
Abstract DNA methylation is a fundamental epigenetic mark that governs gene expression and chromatin organization, thus providing window into cellular identity developmental processes 1 . Current datasets typically include only fraction of sites are often based either on cell lines underwent massive changes in culture or tissues containing unspecified mixtures cells 2–5 Here we describe human methylome atlas, deep whole-genome bisulfite sequencing, allowing fragment-level analysis across...
No AccessJournal of UrologyAdult Urology1 Jun 2014DNA Based Therapy with Diphtheria Toxin-A BC-819: A Phase 2b Marker Lesion Trial in Patients Intermediate Risk Nonmuscle Invasive Bladder Cancer Ofer N. Gofrit, Shalva Benjamin, Sarel Halachmi, Ilan Leibovitch, Zohar Dotan, Donald L. Lamm, Nahum Ehrlich, Vladimir Yutkin, Monique Ben-Am, and Abraham Hochberg GofritOfer Gofrit Hadassah Ein-Kerem Medical Center, Jerusalem, Israel , BenjaminShalva Benjamin Edith Wolfson Sackler Faculty Medicine,...
The sophistication of percutaneous nephrolithotomy and ureteroscopy challenges the efficacy ESWL for urolithiasis in prepubertal patients. We evaluated our long-term experience with these patients determined its efficiency.We retrospectively reviewed charts all who underwent ESWL. need tubing, 3-month stone-free rate, additional ESWL, effect stone size location, cystinuria on rate.Between 1986 2008, 119 males 97 females a mean age 6.6 years had using Dornier HM3 lithotriptor. treated 157...
Abstract Recent reports suggest a far greater plasticity in nerve tissue than previously believed. As the digestive tract is exposed to variety of insults, this question relevant enteric nerves, but little known about their ability recover from damage. To address problem, we ablated myenteric plexus mouse colon with detergent benzalkonium chloride (BAC) and followed ensuing morphologic changes for up 60 days by using light‐ electron microscopy. We found that, 2 after BAC application, treated...
Urothelial carcinomas have an established propensity for divergent differentiation. Most of these variant tumors are muscle invasive but not all. The response non to intravesical immunotherapy with BCG is in the literature, and reported here. Between June 1995 December 2007, 760 patients (mean age 67.5 years) underwent transurethral resection first time bladder our institution. Histologically were found 79 (10.4%). Of 57 (72%) them had muscle-invasive disease or extensive non-muscle...
The pathological grade of bladder cancer has an immense impact on patient treatment and prognosis. While most tumors show pure high or low patterns, some a mixed pattern. We explored the incidence clinical significance this phenomenon.A total 642 patients with mean age 67.5 years underwent transurethral resection nonmuscle invasive between June 1998 December 2008, including 156 454 lesions, respectively. In 32 (5%) were found, defined as 10% less component. All followed median 60 months...
High-grade urothelial carcinomas (UCs) often show foci of variant differentiation. There is limited information in the literature about response these tumors to immunotherapy with bacillus Calmette-Guerin (BCG). We compared response, treatment BCG, UC containing glandular, squamous, nested, and micropapillary types differentiation conventional non-muscle invasive high-grade UC.A total 100 patients were diagnosed histology cancer between June 1995 December 2013. Forty-one Ta or T1, confirmed...
Introduction and Objectives: Ureteroscopy is the gold standard for most urinary tract calculi. Our institute recently incorporated a powerful 120 W holmium laser machine integrating innovative technology (Lumenis® MOSES PulseTM120H Holmium:YAG laser; Lumenis Ltd.). In this retrospective comparative study, we evaluated influence of stone density on dusting time in high-power vs 20 (Dornier Medilas® H20 Dornier Ltd.) Methods: We conducted review medical records patients who underwent...
Abstract DNA methylation is a fundamental epigenetic mark that governs chromatin organization, cell identity, and gene expression. Here we describe human methylome atlas, based on deep whole-genome bisulfite sequencing allowing fragment-level analysis across thousands of unique markers for 39 types sorted from 207 healthy tissue samples. Replicates the same cell-type are >99.5% identical, demonstrating robustness identity programs to genetic variation environmental perturbation....
Abstract Background Bacillus Calmette-Guerin (BCG) therapy is an established immunotherapy for non-muscle invasive bladder cancer (NMIBC); however, the response variability of patients remains a challenge, necessitating insight into immune cell function. Previous studies that preexisting Th2 microenvironment correlates with positive BCG outcome. Therefore, in this study, we explored role mast cells (MCs) and eosinophils as potential predicting tool response. Methods We investigated effect...
Prostate cancer is a common and heterogeneous disease, where androgen receptor (AR) signaling plays pivotal role in development progression. The initial treatment for advanced prostate suppression of signaling. Later on, essentially all patients develop an independent stage which does not respond to anti hormonal treatment. Thus, alternative strategies targeting novel molecular mechanisms are required. beta-TrCP E3 ligase that targets various substrates essential many aspects...
No AccessJournal of UrologyAdult Urology1 Feb 2016External Validation CROES Nephrolithometry as a Preoperative Predictive System for Percutaneous Nephrolithotomy Outcomes Stavros Sfoungaristos, Ofer N. Gofrit, Vladimir Yutkin, Ezekiel H. Landau, Dov Pode, and Mordechai Duvdevani SfoungaristosStavros Sfoungaristos , GofritOfer Gofrit YutkinVladimir Yutkin LandauEzekiel Landau PodeDov Pode DuvdevaniMordechai View All Author Informationhttps://doi.org/10.1016/j.juro.2015.08.079AboutFull TextPDF...
PET-CT using prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals labeled with 68Ga or 18F has emerged as the most sensitive staging tool in prostate cancer (PC). Nonetheless, occurrence of false positive (FP) findings presents a major concern this approach. In prospective study, we investigated frequency and pattern false-positive [18F]PSMA-1007 PET/CT patients after radical prostatectomy undetectable serum PSA levels. Any discrete non-physiological accumulation...