A5060956558- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Urticaria and Related Conditions
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Asthma and respiratory diseases
- Immunotherapy and Immune Responses
- Pneumocystis jirovecii pneumonia detection and treatment
- Inflammasome and immune disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Venous Thromboembolism Diagnosis and Management
- Cell Adhesion Molecules Research
- Galectins and Cancer Biology
- Blood groups and transfusion
- HIV, Drug Use, Sexual Risk
- Autoimmune Bullous Skin Diseases
- Renal Diseases and Glomerulopathies
- Vector-borne infectious diseases
Kaplan Medical Center
2013-2023
Hebrew University of Jerusalem
1994-2023
Weizmann Institute of Science
1994-2018
Hôpital Bichat-Claude-Bernard
2017
Université Claude Bernard Lyon 1
2017
AIDS and Clinical Immunology Research Center
2017
University of Southern Denmark
2017
Odense University Hospital
2017
Tehran University of Medical Sciences
2017
Hadassah Medical Center
2010
CD5-expressing B lymphocytes from patients with selected chronic lymphoproliferative disorders were used to determine whether monoclonal populations of CD5+ human cells produce autoantibodies. 19 lymphocytic leukemia (CLL) and one diffuse well-differentiated lymphoma (DWDL) cultured, without mitogenic stimulation, obtain Ig these cells. 17 the 20 samples produced in vitro. mAb nine reactive either IgG, ssDNA, or dsDNA. In every instance, autoantibodies displayed monotypic L chain usage that...
The cDNA for human beta 2-interferon (IFN-beta 2)/B-cell differentiation factor 2/hepatocyte-stimulating was expressed in Escherichia coli to yield a fusion protein which contains the 182 carboxyl-terminal amino acids of IFN-beta 2 fused 34-amino acid prokaryotic leader peptide (rIFN-beta 2). When added cultures hepatoma cell line Hep3B2, rIFN-beta as well preparations natural enhance secretion positive acute phase reactants such alpha 1-antichymotrypsin, complement C3, fibrinogen, and...
Abstract Sex hormones have been implicated in the pathogenesis of many autoimmune disorders, presumably through regulatory influences on immune system. However, mechanisms sex steroid action humoral and cellular responses are not precisely understood. In this study, vitro effects physiologic concentrations 17 beta-estradiol testosterone Ag non-specific differentiation human PBMC were examined using optimal sub-optimal doses, respectively, PWM. cultures from 14 normal donors (7 men 7 women,...
Abstract The Ku (p70/p80) autoantigen consists of two phosphoproteins molecular mass approximately 70,000 and 80,000 forming a macromolecular complex that binds DNA. Autoantibodies from patient with systemic lupus erythematosus were used to isolate cDNA clones encoding the human 70-kDa antigen (p70) lambda gt11 expression library. deduced amino acid sequence p70 consisted 609 residues was confirmed by partial sequencing. protein contains acidic domains 61 (31% Glu + Asp) 19 (53% are similar...
The human beta 2 interferon (IFN-beta 2) gene, a gene that also codes for B cell differentiation factor (BSF-2), plasmacytoma/hybridoma growth (HGF), and hepatocyte-stimulating (HSF), is expressed in variety of lymphoid nonlymphoid tissues. Endotoxin, or bacterial lipopolysaccharide (LPS) preparations derived from the outer membrane Escherichia coli Salmonella typhimurium rapidly elevate IFN-beta mRNA level skin fibroblasts (FS-4 strain). E. coli-derived LPS enhances expression FS-4 at...
The antiphospholipid syndrome is characterized by thrombocytopenia, thrombosis, and recurrent fetal loss in association with anti-cardiolipin antibodies (ACAs) or lupus anti-coagulants. However, the causal role of these disease mechanisms which ACA may induce are not clear. Recently, we have established an experimental mouse induced IgM monoclonal designated 2C4C2. In present study, focused on effects immunization 2C4C2 outcome pregnancies BALB/c female mice. Four weeks after active ACA, a...
<h3>Background</h3> The diagnosis of iron deficiency anemia (IDA) in the elderly is difficult because prevalence chronic diseases, which can cause with high ferritin levels, even presence deficiency. Therefore, we studied sensitivity and specificity a serum transferrin receptor assay, not affected by IDA patients. <h3>Methods</h3> We performed prospective controlled study 49 consecutive male female patients older than 80 years who were admitted to an acute geriatric department. Bone marrow...
European guidelines recommend the routine offer of an HIV test in patients with a number AIDS-defining and non-AIDS conditions believed to share association HIV; so called indicator (IC). Adherence this guidance across Europe is not known. We audited testing behaviour accessing care for ICs. Participating centres reviewed case notes either 100 or all consecutive one year, presenting each following ICs: tuberculosis, non-Hodgkins lymphoma, anal cervical cancer, hepatitis B C oesophageal...
To determine the prevalence of autoantibodies directed against an epitope glutamate/N-methyl-D-aspartic acid (NMDA) receptor subunit NR2A (which is highly expressed in human brain) sera lupus patients, and to investigate possible correlation these antibodies with clinical serological manifestations systemic erythematosus (SLE).Sera were obtained from 109 consecutive SLE patients. Controls 65 patients myasthenia gravis, 19 autoimmune polyendocrine syndrome type I (APS I), healthy donors. A 15...
Journal Article Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin Get access Silke Aigner, Aigner 1Tumor Immunology Programme, 0710, German Cancer Research CenterD-69120 Heidelberg, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael Ruppert, Ruppert Marcus Hubbe, Hubbe Marei Sammar, Sammar Zev Sthoeger, Sthoeger Eugene C. Butcher, Butcher 2The Laboratory of Vascular Biology, Department Pathology...
Systemic lupus erythematosus is an autoimmune disease characterized by autoantibodies and systemic clinical manifestations. A peptide, designated hCDR1, based on the complementarity-determining region (CDR) 1 of autoantibody, ameliorated serological manifestations in both spontaneous induced murine models lupus. The objectives present study were to determine mechanism(s) underlying beneficial effects hCDR1. Adoptive transfer hCDR1-treated cells erythematosus-afflicted (NZBxNZW)F1 female mice...
Previous studies reported controversial results regarding the association between allergic disorders and attention deficit hyperactivity disorder (ADHD)/autism spectrum (ASD). The aim of this article was to investigate whether are associated with ADHD/ASD in a large cohort pediatric patients.
Summary Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the increased production of autoantibodies and systemic clinical manifestations damage to multiple organs. The aim present study was analyse matrix metalloproteinase (MMP)-9 activity in sera patients with active inactive SLE order evaluate its role pathogenesis course disease, as well diagnostic value. We measured levels MMP-9 MMP-2, using both gel zymography assay kits, 40 25 healthy controls. found that...
<h3>Objective.</h3> To study predictors of discordance between self-reported physician diagnosis and administrative database arthritis. <h3>Methods.</h3> A cohort all veterans who utilized Veterans Integrated Service Network (VISN)-13 medical facilities were mailed a questionnaire that included patient self-report arthritis questions regarding demographics, functional limitation, SF-36V (a validated version the Medical Outcomes Study Short-Form 36). Kappa coefficient was used to assess...
In an attempt to elucidate the role of oestrogens in systemic lupus erythematosus (SLE) we investigated effects treatment with oestrogen antagonist – tamoxifen and a monoclonal anti‐oestradiol (anti‐E2) antibody on mice which experimental was induced by human anti‐DNA bearing 16/6 idiotype (16/6 Id). Thus, groups BALB/c female were immunized Id 3 weeks following booster injection, when titres elevated injected mice, protocols or initiated. Control that not but similarly treated above agents...
Studies have suggested that HIV-1 may develop thymidine analogue mutations (TAMs) by one of two distinct pathways - the TAM1 pathway (including 41L, 210W and 215Y) or TAM2 67N, 70R 219E/Q) under pressure a not fully suppressive thymidine-analogue-containing regimen.Frozen plasma samples stored in EuroSIDA repository were selected sent to central laboratories for genotypic analysis. We considered 733 patients with at least test showing > =1 TAMs (the first these tests chronological order was...