Hiba Zayyad
A5050401988- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Antibiotics Pharmacokinetics and Efficacy
- Pneumonia and Respiratory Infections
- COVID-19 and healthcare impacts
- Viral Infections and Vectors
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Vaccine Coverage and Hesitancy
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Clinical Reasoning and Diagnostic Skills
- Vector-borne infectious diseases
- Mosquito-borne diseases and control
- Urinary Tract Infections Management
- Psychological Well-being and Life Satisfaction
- Respiratory Support and Mechanisms
- Vibrio bacteria research studies
- Neurological diseases and metabolism
- Nuclear Receptors and Signaling
- Pharmaceutical and Antibiotic Environmental Impacts
- Burkholderia infections and melioidosis
Bar-Ilan University
2021-2024
Poriya Medical Center
2019-2024
Azrieli College of Engineering Jerusalem
2023
All India Institute of Medical Sciences Raipur
2023
All India Institute of Medical Sciences Rishikesh
2023
Institut de Recherche Vaccinale
2022
Rambam Health Care Campus
2017-2021
University of Oxford
2021
Infectious Diseases Institute
2018
Hadassah Medical Center
2013
Gram-negative bacteremia is a major cause of morbidity and mortality in hospitalized patients. Data to guide the duration antibiotic therapy are limited.This was randomized, multicenter, open-label, noninferiority trial. Inpatients with gram-negative bacteremia, who were afebrile hemodynamically stable for at least 48 hours, randomized receive 7 days (intervention) or 14 (control) covering therapy. Patients uncontrolled focus infection excluded. The primary outcome 90 composite all-cause...
Abstract The effectiveness of Coronavirus disease 2019 (COVID-19) vaccines against the long-term COVID-19 symptoms expressed by a substantial proportion patients is not well understood. We determined whether vaccination with BNT162b2 mRNA vaccine was associated incidence reporting post-SARS-CoV-2 infection. invited individuals PCR-tested for SARS-CoV-2 infection at participating hospitals between March 2020 and November 2021 to fill an online questionnaire that included information about...
Abstract Background Long COVID is a post-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection characterised by not recovering for several weeks or months following the episode. The effectiveness of COVID-19 vaccines against long-term symptoms well understood. We determined whether vaccination was associated with incidence reporting post-SARS-CoV-2 Methods invited individuals who were PCR tested SARS-CoV-2 at participating hospitals between March 2020-November 2021 to fill...
Abstract Background We evaluated the association between mortality and colistin resistance in Acinetobacter baumannii infections interaction with antibiotic therapy. Methods This is a secondary analysis of randomized controlled trial patients carbapenem-resistant gram-negative bacterial treated or colistin-meropenem combination. infection caused by A. (CRAB) identified as susceptible (CoS) at time treatment compared which isolate was confirmed CoS those whose isolates were retrospectively...
Abstract The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases prospectively collected clinical data on people hospitalized with COVID-19. This was compiled during pandemic by a network hospitals that collect using ISARIC-World Health Organization Clinical Characterization Protocol tools. database includes from more than 705,000 patients, in 60 countries 1,500 centres worldwide. Patient are...
<h3>Importance</h3> Despite the high 3-dose vaccination rate among health care workers (HCWs) in Israel, a of SARS-CoV-2 breakthrough infections this group was observed during Omicron wave. As result, Israeli Ministry Health decided to recommend fourth vaccine dose medical staff. <h3>Objective</h3> To evaluate benefit BNT162b2 on infection HCWs. <h3>Design, Setting, and Participants</h3> This multicenter cohort study performed January 2022, first month 4-dose campaign, surge variant All at...
Abstract Although it is known that coronavirus disease 2019 can present with a range of neurological manifestations and in-hospital complications, sparse data exist on whether these initial symptoms are closely associated post-acute sequelae SARS-CoV-2 (severe acute respiratory syndrome 2; PANSC) female versus male sex impacts symptom resolution. In this international, multi-centre, prospective, observational study across 407 sites from 15 countries (30 January 2020 to 30 April 2022), we...
Colistin heteroresistance (HR) refers to a bacterial population comprised of several subpopulations with different levels resistance colistin. In this study, we discuss the classic form HR, in which resistant subpopulation exists within predominantly susceptible population. We investigated prevalence colistin HR and its evolution into full among 173 clinical carbapenem-resistant Acinetobacter baumannii isolates examined effect on outcomes. To determine performed analysis profiling. Our...
The impact of Coronavirus disease-2019 (COVID-19) extends beyond health, potentially affecting long-term income and employment dynamics. In Israel, disparities exist between Jewish Arab populations across many dimensions, including socioeconomic. study's primary aim was to compare changes in among COVID-19-infected non-infected participants Jews Arabs, the two main population groups comprising Israel. We conducted a cross-sectional study March 2021 June 2022 adults employed prior pandemic,...
Abstract Background Empirical colistin should be avoided. We aimed to evaluate the association between covering empirical antibiotics (EAT) and mortality for infections caused by carbapenem-resistant gram-negative bacteria (CRGNB). Methods This was a secondary analysis of randomized controlled trial, including adults with bloodstream infections, pneumonia, or urosepsis CRGNB. All patients received EAT followed targeted therapy. The exposure variable in first 48 hours. outcome 28-day...
Investigating the effect of different face masks on dry eye disease (DED) among healthcare workers during COVID-19 pandemic.This was a comparative, cross-sectional study. Participants were included into two groups: group 1 (n = 30) wore surgical masks, and 2 N95 with shields. Demographic ocular surface index questionnaires (OSDI) performed. In addition, Tear break-up time (TBUT), corneal conjunctival fluorescein staining, meibography to assess meibomian gland loss (MGL) performed all...
We evaluated whether carbapenem-colistin combination therapy reduces the emergence of colistin resistance, compared to monotherapy, when given patients with infections due carbapenem-resistant Gram-negative organisms.This is a pre-planned analysis secondary outcome from randomized, controlled trial comparing monotherapy colistin-meropenem for treatment severe caused by carbapenem-resistant, colistin-susceptible bacteria. rectal swabs taken on Day 7 or later presence new colistin-resistant...
The association between Body Mass Index (BMI) and clinical outcomes following sepsis continues to be debated. We aimed investigate the relationship BMI in-hospital course mortality in patients hospitalized with bacteremic using real-world data. A sampled cohort of October 2015 December 2016 was identified National Inpatient Sample (NIS) database. In-hospital length stay were defined as relevant outcomes. Patients divided into 6 (kg/m2) subgroups; (1) underweight ≤ 19, (2) normal-weight...
Optimal treatment of carbapenem-resistant Gram-negative bacteria (CR-GNB) infections is uncertain because the lack good-quality evidence and limited effectiveness available antibiotics. The aim this survey was to investigate clinicians' prescribing strategies for treating CR-GNB worldwide.A 36-item questionnaire developed addressing following aspects antibiotic prescribing: respondent's background, diagnostic therapeutic availability, preferred rationale selecting combination therapy....
Abstract In a multicenter, nationwide, retrospective study of patients hospitalized with spotted fever group rickettsiosis in Israel during 2010–2019, we identified 42 cases, which 36 were autochthonous. The most prevalent species was the Rickettsia conorii Israeli tick typhus strain (n = 33, 79%); infection this necessitated intensive care for 52% and associated 30% fatality rate. A history bite rare, found only 5% patients; eschar 12%; leukocytosis more common than leukopenia. Most (72%)...
Parkinson's disease is a progressive neurodegenerative disorder, where most cases are sporadic with late onset. In rare incidences familial forms of early-onset parkinsonism occur, and when recessively inherited, often explained by mutations in either the parkin (PARK2) or PINK1 (PARK6) gene on exceptional occasions DJ-1 (PARK7) ATP13A2 (PARK9) gene. Recessively inherited deletions/duplications point common cause known so far, but an increasing number studies, genetic variations...
The clinical features of spotted fever group (SFG) Rickettsia induced disease range from a mild to severe illness. complexity is even greater due the fact that can be caused by different species with varying degrees virulence. Current knowledge asserts Israeli SFG (ISF) strain conorii israelensis only human pathogenic member in Israel. diagnostic procedures distinguish between and typhus rickettsiosis, assuming all SFG-positive samples positive for ISF. Molecular studies on questing ticks...
Background Changing patterns of vaccine breakthrough can clarify effectiveness. Aim To compare infections during a SARS-CoV-2 Delta wave vs unvaccinated inpatients, and an earlier Alpha wave. Methods In observational multicentre cohort study in Israel, hospitalised COVID-19 patients were divided into three cohorts: Comirnaty-vaccinated (VD; Jun–Aug 2021) cases the (ND) (VA; Jan–Apr 2021). Primary outcome was death or ventilation. Results We included 343 VD, 162 ND 172 VA patients. VD more...
Abstract Background Population external validity is the extent to which an experimental study results can be generalized from a specific sample defined population. In order apply of study, we should able assess its population validity. We performed investigator-initiated randomized controlled trial (RCT) (AIDA study), compared colistin-meropenem combination therapy colistin monotherapy in treatment patients infected with carbapenem-resistant Gram-negative bacteria. examine study’s and...
The impact of individual symptoms reported post-COVID-19 on subjective well-being (SWB) is unknown. We described associations between SWB and selected following SARS-CoV-2 infection. analysed well being from 2295 participants (of which 576 reporting previous infection) in an ongoing longitudinal cohort study taking place Israel. estimated changes associated with at three follow-up time points (3-6, 6-12 12-18 months post among infection, adjusted for key demographic variables, using linear...