Carolline Araujo
A5103098306- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- COVID-19 and healthcare impacts
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Genital Health and Disease
- BRCA gene mutations in cancer
- Mosquito-borne diseases and control
- Sepsis Diagnosis and Treatment
- Hepatitis B Virus Studies
- Respiratory Support and Mechanisms
- Diabetes Management and Research
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 diagnosis using AI
- Malaria Research and Control
- Viral Infections and Vectors
- COVID-19 Pandemic Impacts
- Lipid metabolism and disorders
- Healthcare during COVID-19 Pandemic
- Cardiovascular Issues in Pregnancy
- Tuberculosis Research and Epidemiology
Fundação Oswaldo Cruz
2021-2024
Faculdades Oswaldo Cruz
2024
Hospital de Câncer de Pernambuco
2019-2022
University of Oxford
2021
Universidade Federal de Pernambuco
2011-2019
Different neurological manifestations of coronavirus disease 2019 (COVID-19) in adults and children their impact have not been well characterized. We aimed to determine the prevalence in-hospital complications among hospitalized COVID-19 patients ascertain differences between children. conducted a prospective multicentre observational study using International Severe Acute Respiratory emerging Infection Consortium (ISARIC) cohort across 1507 sites worldwide from 30 January 2020 25 May 2021....
Abstract The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases prospectively collected clinical data on people hospitalized with COVID-19. This was compiled during pandemic by a network hospitals that collect using ISARIC-World Health Organization Clinical Characterization Protocol tools. database includes from more than 705,000 patients, in 60 countries 1,500 centres worldwide. Patient are...
Abstract Background Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive (IMV). We aimed describe the clinical characteristics, outcomes and risk factors for failing support in treated severe during first two years pandemic high-income countries (HICs) low middle-income (LMICs). Methods This is a multinational, multicentre, prospective cohort study embedded...
The four Dengue viruses (DENV) serotypes were re-introduced in Brazil's Northeast region a couple of decades, between 1980's and 2010's, where the DENV1 was first detected serotype DENV4 latest. Zika (ZIKV) Chikungunya (CHIKV) introduced Recife around 2014 led to large outbreaks 2015 2016, respectively. However, true extent ZIKV CHIKV outbreaks, as well risk factors associated with exposure these remain vague.We conducted stratified multistage household serosurvey among residents aged 5 65...
A cross-sectional study was conducted using body mass index (BMI) to estimate the prevalence of thinness and overweight/obesity associated factors in 2,018 individuals with HIV/AIDS attending health services referral centers. The dependent variable classified as thinness, eutrophy. Multinomial logistic regression analyses were performed considering eutrophy reference level. 8.8% overweight/obesity, 32.1%. variables anemia CD4 cell count < 200mm³. risk age > 40 years diabetes, identified...
The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) is a global federation of clinical research networks that work collaboratively to prevent illness deaths from infectious disease outbreaks. In 2014, we proposed effective timely during outbreaks emerging infections would benefit pre-prepared tools, collaboration, research-ready networks.1 After applying this model several outbreaks, particularly the COVID-19 pandemic, can now explore what has been achieved date.
Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining relationship between COVID-19 AKI low- low-middle income countries (LLMIC) are lacking. Given that is known to carry a higher mortality rate these countries, it important understand differences this population.
Hepatotoxicity is frequently reported as an adverse reaction during the treatment of tuberculosis. The aim this study was to determine incidence hepatotoxicity and identify predictive factors for developing after people living with HIV/AIDS (PLWHA) start This a prospective cohort PLWHA who were monitored first 60 days tuberculosis in Pernambuco, Brazil. considered increased levels aminotransferase, namely those that rose three times higher than level before initiating treatment, these being...
Research diversity and representativeness are paramount in building trust, generating valid biomedical knowledge, possibly implementing clinical guidelines.
By September 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 deaths. COVID-19 mortality risk estimators are often, however, developed with small unrepresentative samples and methodological limitations. It is highly important to develop predictive tools for pulmonary embolism (PE) patients as one the most severe preventable complications COVID-19. Early recognition can help provide life-saving targeted anti-coagulation therapy right...
Objectives We assessed the prevalence of SARS-CoV-2 infection, personal protective equipment (PPE) shortages and occurrence biological accidents among front-line healthcare workers (HCW). Design, setting participants Using respondent-driven sampling, study recruited distinct categories HCW attending suspected or confirmed patients with COVID-19 from May 2020 to February 2021, in Recife metropolitan area, Northeast Brazil. Outcome measures The criterion assess infection was a positive...
We present a genome polymorphisms/machine learning approach for severe COVID-19 prognosis. Ninety-six Brazilian patients and controls were genotyped 296 innate immunity loci. Our model used feature selection algorithm, namely recursive elimination coupled with support vector machine, to find the optimal loci classification subset, followed by machine linear kernel (SVM-LK) classify into group. The best features that selected SVM-RFE method included 12 SNPs in genes: PD-L1, PD-L2, IL10RA,...
Infection with hepatitis B virus (HBV) and C (HCV) are common in patients HIV/AIDS tuberculosis (TB). This is a cross-sectional study infected active TB Recife, Brazil, aiming to verify the prevalence of markers for HBV: antibody core antigen (anti-HBc); HCV: (anti-HCV) by chemiluminescence, identify frequency associated factors. Data were collected through questionnaires, blood was drawn from analysis. We used chi-square test Fisher exact when necessary. conducted bivariate logistic...
Hepatotoxicity during tuberculosis (TB) treatment is frequent and may be related to the Arylamine N-Acetyltransferase (NAT2) acetylator profile, in which allele frequencies differ according population. The aim of this study was investigate functional polymorphisms NAT2 associated with development hepatotoxicity after initiating for TB people living HIV/AIDS (PLWHA) Pernambuco, Northeast Brazil.This a prospective cohort that investigated seven single nucleotide located coding region 173 PLWHA...
RESUMO Objetivo: Estimar a probabilidade da ocorrência de infecção pelos vírus das hepatites B (HBV) e C (HCV) em diferentes estratos socioeconômicos população Recife, Nordeste do Brasil. Métodos: Estudo realizado com base amostras obtidas um inquérito residentes grande centro urbano que teve populacional amostragem estratificada seleção aleatória dos domicílios por meio pacote “Amostra Brasil” no software R. A pesquisa antígeno superfície HBV (HBsAg) anti-HCV foi realizada testes...
Germline mutations in BRCA1 and BRCA2 genes are among the main causes of hereditary ovarian cancer. Identifying these may reduce cancer risk, facilitate early detection, enable personalized treatment. However, genetic testing is limited Brazilian Public Health System, data regarding germline many regions scarce. Therefore, study aimed to investigate prevalence women with treated System Pernambuco, Brazil.
The need for the identification of risk factors associated to COVID-19 disease severity remains urgent. Patients' care and resource allocation can be potentially different are defined based on current classification severity. This is analysis clinical parameters routine blood tests, which not standardized across globe. Some laboratory test alterations have been severity, although these data conflicting partly due methodologies used studies. study aimed construct validate a prediction model...
ABSTRACT Objective: To estimate the probability of infection with hepatitis B (HBV) and C (HCV) viruses in different socioeconomic strata population Recife, Northeast Brazil. Methods: Study carried out from samples obtained a survey residents large urban center that had base stratified sampling random selection households using “Brazil Sample” package R software. HBV (HBsAg) anti-HCV was performed immunochromatographic tests. In cases positive for HBsAg, anti-HBc HBeAg were tested...
Abstract Background Measuring the presence and pattern of periportal fibrosis (PPF) in schistosomiasis mansoni (SM) is essential for diagnosing its clinical forms detection portal hypertension. For these evaluations, gold-standard has been ultrasound scan (US) using Niamey classification, however it requires sophisticated equipment well-trained operator. ELF (Enhanced Liver Fibrosis) an index capable quantifying liver chronic diseases, although there have few studies evaluating PPF SM. Aim...
The occurrence of hepatitis E virus (HEV) in patients with Schistosomiasis mansoni (SM) is still poorly understood Brazil. objective this study was to estimate the seroprevalence anti-HEV IgG SM and its association periportal fibrosis (PPF), assessed by serum markers ultrasound criteria. This cross-sectional carried out an endemic area Pernambuco, Brazil, schistosomal who underwent coproscopic survey. Anti-HEV antibody were evaluated using ELISA (Euroimmun®, Lübeck, Germmany). In positive...
Abstract Background The Dengue viruses (DENV) serotypes 1, 2, 3 and 4 were re-introduced in the Northeast Brazil from 1980’s until 2010’s. Zika (ZIKV) Chikungunya (CHIKV) introduced around 2014 caused large outbreaks 2015 2016. However, true extent of ZIKV CHIKV risk factors associated with exposure remain vague. Methods We conducted a stratified multistage household serosurvey among residents aged between 5 65 years city Recife, Northeastern Brazil, August 2018 to February 2019....
Abstract Introduction The disparities in the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among frontline health care workers (HCWs) and unique work circumstances are poorly documented for low-and middle-income countries. Methods We assessed frequency SARS-CoV-2 infection, personal protective equipment (PPE) shortages, PPE use, accidents involving biological material HCWs Recife metropolitan area, Northeast Brazil. Using respondent driven sampling, we...
Objetivo: O câncer de pênis tem alta incidência em alguns países desenvolvimento e a metástase linfonodos da cadeia inguinal é um grande desafio no tratamento dessa neoplasia. objetivo deste estudo foi identificar prevalência metástases inguinais seus fatores associados pacientes com pênis.Métodos: Conduzimos uma análise retrospectiva todas as consultas lesões penianas realizadas por homens adultos nossa instituição. Metástase constituiu o evento interesse definida partir presença carcinoma...