A5004185727- Intraperitoneal and Appendiceal Malignancies
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Gastric Cancer Management and Outcomes
- Cervical Cancer and HPV Research
- Metastasis and carcinoma case studies
- Endometriosis Research and Treatment
- Intestinal and Peritoneal Adhesions
- Appendicitis Diagnosis and Management
- Gastrointestinal Tumor Research and Treatment
- Organ Transplantation Techniques and Outcomes
- Colorectal and Anal Carcinomas
- Women's cancer prevention and management
- Hernia repair and management
- Liver Disease and Transplantation
- BRCA gene mutations in cancer
- Gastrointestinal disorders and treatments
- Uterine Myomas and Treatments
- Neuroendocrine Tumor Research Advances
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Risks and Factors
- Organ Donation and Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Diagnosis and Treatment
- Urinary and Genital Oncology Studies
Universidade Federal de Pernambuco
2017-2024
Hospital das Clínicas da Universidade Federal de Pernambuco
2023-2024
Real Hospital Português
2023
Instituto de Medicina Integral Professor Fernando Figueira
2013-2022
Univar (United Kingdom)
2022
Hospital de Câncer de Pernambuco
2013-2021
Universidade de Pernambuco
2009-2017
Symbiosis Group
2015
Symbiosis International University
2015
Instituto de Tecnologia de Pernambuco
2013
<h3>Objective</h3> To evaluate the non-inferiority and safety of simple hysterectomy in early stage (<2 cm) cervical cancer. <h3>Methods</h3> This proof-of-concept randomized phase II trial was performed between May 2015 April 2018 three oncological centers Northeast Brazil. Patients with International Federation Gynecology Obstetrics (FIGO) 2009 stages IA2–IB1 cancer tumors ≤2 cm were treated either or modified radical (Querleu–Morrow type B2). Intention-to-treat analysis carried out....
To analyze the impact of model for end-stage liver disease (MELD) allocation policy on survival outcomes after transplantation (LT).Considering that an ideal system grafts should also ensure improved transplantation, changes in policies need to be evaluated different contexts as evolutionary process.A retrospective cohort study was carried out among patients who underwent LT at University Pernambuco. Two groups transplanted before and MELD implementation were identified compared using early...
Gallbladder cancer is sometimes incidentally uncovered following cholecystectomy for gallstones diseases. The supposed highly variable prevalence of incidental gallbladder through our country unknown.To explore the in tertiary-care hospital.A cross-sectional study was carried out on patients who consecutively underwent due to disease at Faculdade Pernambucana de Saúde, Instituto Medicina Integral Professor Fernando Figueira - FPS/IMIP, from January, 2007 December, 2010. Data were explored...
Background and Objectives OX40, a membrane‐bound molecule of the tumor‐necrosis‐factor‐receptor superfamily, is critical costimulatory receptor during immune response, especially to T cells, but studies described their presence OX‐40 on neutrophils monocytes, suggesting potential role in activation response. Our aim was characterize receptors OX40 expression circulating leukocytes gastric cancer identify novel targets for immunotherapy. Methods Peripheral blood mononuclear cells were...
ABSTRACT Cytoreductive surgery plus hypertermic intraperitoneal chemotherapy has emerged as a major comprehensive treatment of peritoneal malignancies and is currently the standard care for appendiceal epithelial neoplasms pseudomyxoma peritonei syndrome well malignant mesothelioma. Unfortunately, there are some worldwide variations cytoreductive techniques since no single technique so far demonstrated its superiority over others. Therefore, standardization practices might enhance better...
Abstract Background The main aim of this study was describe the author's experience with class II radical hysterectomy and pelvic lymphadenectomy to treat stage I–IIA cervix cancer reexamine some prognostic factors associated disease recurrence patient survival in data from northeast Brazil. Methods A cross‐sectional carried out on patients treated at our Centers January 2001 December 2008. Statistical analyses were performed using conventional methods. Results Eighty‐eight selected...
Hyperthermic intraperitoneal chemotherapy (HIPEC) has been considered a promising treatment option for advanced or recurrent ovarian cancer, but there is no clear evidence based on randomized controlled trials to advocate this approach as standard therapy. In study, we aim present the early outcomes and insights after an interim analysis of pioneering clinical trial in Brazil.This study was cross-sectional data from our ongoing - open-label, double-center, single-arm safety efficacy using...
The Extensive Intraoperative Peritoneal Lavage (EIPL) has been proposed as a practical prophylactic strategy to decrease the risk of peritoneal metastasis in gastric cancer.To explore safety and efficacy EIPL our locally advanced cancer patients.This study is an open-label, double-center, single-arm phase II clinical trial developed at two tertiary hospitals from Recife (Pernambuco, Brazil).The protocol was prematurely closed due slow accrual after only 16 patients had recruited participate....
OBJETIVO: Analisar a acurácia geral do escore MELD pré-operatório para predição da sobrevivência pós-transplante hepático (TH) e explorar fatores preditivos de médio prazo (24 meses). MÉTODOS: Estudo corte transversal incluindo pacientes transplantados pelo Serviço Cirurgia Geral Transplante Hepático Hospital Universitário Oswaldo Cruz, Universidade Pernambuco, entre 15 julho 2003 14 2009. Utilizou-se análise área sob curva ROC (receiver operating characteristic) como medida-resumo...
ABSTRACT Objective: to report the final analysis of a phase 2 trial assessing efficacy and safety short-course hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with advanced epithelial ovarian cancer (EOC). Methods: this was an open-label, multicenter, single-arm HIPEC in EOC who underwent interval cytoreductive surgery (iCRS) after neoadjuvant (NACT). performed as concentration-based regimen platinum-based 30 minutes. Primary endpoint rate disease progression occurring at nine...
ABSTRACT Introduction: to evaluate the effect of short-course (i.e.: 30 minutes) HIPEC on health-related quality life (HRQoL) in our feasibility study; NCT02249013. Methods: a prespecified secondary end-point open-label, multicenter, single-arm, phase 2 trial safety and efficacy was assessed using European Organization for Research Treatment Cancer Quality Life Questionnaire Core (EORTC QLQ-C30, version 3.0). Patients were required complete HRQoL questionnaire at baseline, after HIPEC, end...
To explore how important is the number of pelvic lymph nodes dissected for nodal staging in FIGO IA2-IB2 cervical cancer, submitted to radical surgical treatment.A cross-sectional study was carried out on patients who underwent Piver class II hysterectomy and lymphadenectomy, two centers state Pernambuco, from January, 2001 December, 2008. The analysis area under ROC curve adopted as a summary-measure discriminatory power predicting status. Additionally, we also confirm our findings using...
the main aim of this study was to describe authors' experience with surgical treatment endometrial cancer without systematic lymphadenectomy.a retrospective cohort carried out on a subset patients suffering clinically early-stage carcinoma who underwent hysterectomy and salpingo-oophorectomy (radical) lymph nodes dissection at our centers from June, 2002, November, 2011. Descriptive statistics were explored as medians (interquartile range) or frequencies (percentages), appropriated,...
Whether adjuvant chemoradiotherapy may contribute to improve survival outcomes after D2-gastrectomy remains controversial.To explore the clinical utility of N-Ratio in selecting gastric cancer patients for D2-gastrectomy.A retrospective cohort study was carried out on who underwent alone or plus (INT-0116 protocol) at Hospital A. C. Camargo from September 1998 December 2008. Statistical analysis were performed using multiple conventional methods, such as c-statistic, adjusted Cox's...
ABSTRACT Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a main comprehensive treatment of peritoneal malignancies. However, current data on the literature are very heterogeneous in terms its technical particularities, which require some efforts to standardization practices. In these setting, we present early from pioneering clinical trial Brazil (ClinicalTrials.gov Identifier: NCT02249013) explore dynamic relationships between flow rates and...
PURPOSE: To explore the effect of acute kidney injury (AKI) on long-term survival after conventional orthotopic liver transplantation (OLT) without venovenous bypass (VVB). METHODS: A retrospective cohort study was carried out 153 patients with end-stage diseases transplanted by Department General Surgery and Liver Transplantation University Pernambuco, from August, 1999 to December, 2009. The Kaplan-Meier estimates log-rank test were applied association between AKI patient survival,...