A5025579727- CAR-T cell therapy research
- Tuberculosis Research and Epidemiology
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Renal and related cancers
- Mycobacterium research and diagnosis
- Pancreatic and Hepatic Oncology Research
- Immunodeficiency and Autoimmune Disorders
- Diagnosis and treatment of tuberculosis
- Stress Responses and Cortisol
- Silicon Carbide Semiconductor Technologies
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- T-cell and B-cell Immunology
- Regulation of Appetite and Obesity
- Diet and metabolism studies
AC Camargo Hospital
2021-2025
Universidade Federal de Juiz de Fora
2015
To better understand the immune microenvironment of pancreatic ductal adenocarcinomas (PDACs), here we explored relevance T and B cell compartmentalisation into tertiary lymphoid structures (TLSs) for generation local antitumour immunity.We characterised functional states spatial organisation PDAC-infiltrating cells using single-cell RNA sequencing (scRNA-seq), flow cytometry, multicolour immunofluorescence, gene expression profiling microdissected TLSs, as well in vitro assays. In addition,...
Abstract Chimeric antigen receptor (CAR) T cell therapy is increasingly being adopted as a clinical modality for patients with relapsed/refractory hematological malignancies. Despite the efficacy of CAR-T therapy, considerable fraction still relapses during first months following infusion. The limited efficiency thought to relate epigenetic mechanisms involved in suppression and dysfunction. Here, screening multiple inhibitors revealed that targeting PRC2 consistently induced development...
The complete regression of clear cell renal carcinoma (ccRCC) obtained pre-clinically with anti-carbonic anhydrase IX (CAIX) G36 chimeric antigen receptor (CAR) T cells in doses equivalent to ≅108 CAR cells/kg renewed the potential this target treat ccRCC and other tumors hypoxia. immune checkpoint blockade (ICB) brought durable clinical responses advanced tumors. Here, we tested CD8α/4-1BB compared CD28-based anti-CAIX peripheral blood mononuclear (PBMCs) releasing anti-programmed death...
The complete regression of clear cell renal carcinoma (ccRCC) obtained pre-clinically with anti-carbonic anhydrase IX (CAIX) G36 chimeric antigen receptor (CAR) T cells in doses equivalent to 10e8 CAR cells/ Kg renewed the potential this target treat ccRCC and other tumors hypoxia. immune checkpoint blockade (ICB) brought durable clinical responses advanced tumors. Here we tested CD8/4-1BB compared CD28-based anti-CAIX PBMCs cells-releasing anti-programmed death ligand-1 (PD-L1) IgG4 for...
Abstract Obesity is a worldwide epidemic that features multifactorial syndrome characterized by chronic positive energetic unbalance. Neonatal administration of monosodium L-glutamate (MSG) causes lesion on the arcuate nucleus hypothalamus led to development obesity in adult life rodents notorious accumulation catecholamine adrenal medulla. The amino acid glycine induces secretion Thus, objective our work was evaluate possible effects MSG-obesity model rats and investigate its impact medulla...