A5023398906- Adenosine and Purinergic Signaling
- Neurological Complications and Syndromes
- Adolescent and Pediatric Healthcare
- Mast cells and histamine
- Folate and B Vitamins Research
- Immune Cell Function and Interaction
- Immune cells in cancer
- Genetics and Neurodevelopmental Disorders
- Dialysis and Renal Disease Management
- Immunotherapy and Immune Responses
- Histone Deacetylase Inhibitors Research
- Neonatal Health and Biochemistry
- Synthesis and Biological Evaluation
- Neonatal Respiratory Health Research
- Childhood Cancer Survivors' Quality of Life
- Pancreatic function and diabetes
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Bone Tumor Diagnosis and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Oral and Maxillofacial Pathology
- Ion channel regulation and function
- PI3K/AKT/mTOR signaling in cancer
- Heat shock proteins research
- Perfectionism, Procrastination, Anxiety Studies
Universidade La Salle
2016-2024
Pontifícia Universidade Católica do Rio Grande do Sul
2011-2022
Universidad Latina
2016
Universidade Federal do Rio Grande do Sul
2009-2015
Universidade Federal de Santa Maria
2004-2010
Macrophages are key elements in the inflammatory process, whereas depending on micro-environmental stimulation they exhibit a pro-inflammatory (classical/M1) or an anti-inflammatory/reparatory (alternative/M2) phenotype. Extracellular ATP can act as danger signal adenosine generally serves negative feedback mechanism to limit inflammation. The local increase nucleotides communication is controlled by ectonucleotidases, such members of ectonucleoside triphosphate diphosphohydrolase...
Abstract Background Adenosine triphosphate (ATP) is secreted from hepatocytes under physiological conditions and plays an important role in liver biology through the activation of P2 receptors. Conversely, higher extracellular ATP concentrations, as observed during necrosis, trigger inflammatory responses that contribute to progression injury. Impaired calcium (Ca 2+ ) homeostasis a hallmark acetaminophen (APAP)-induced hepatotoxicity, since induces mobilization intracellular Ca stocks, we...
Macrophages are involved in cancer progression. M1 macrophages have an antitumor effect, whereas M2 phenotype associated with tumor growth. The progression of gliomas involves the participation inflammatory microenvironment. Adenosine triphosphate (ATP) can act as pro-inflammatory signal, adenosine has opposite properties. biological effects extracellular nucleotides/nucleosides mediated by purinergic receptors controlled ectonucleotidases. In present work, we evaluated whether...
Glioblastoma multiforme (GBM) is considered the most lethal intracranial tumor and median survival time approximately 14 months. Although some glioma cells present radioresistance, radiotherapy has been mainstay of therapy for patients with malignant glioma. The activation P2X7 receptor (P2X7R) responsible ATP-induced death in various cell types. In this study, we analyzed importance ATP-P2X7R pathway response P2X7R silenced lines, vivo human samples. Both lines used study a functional...
ABSTRACT Mesenchymal stem cells (MSCs) have shown a great potential for cell‐based therapy and many different therapeutic purposes. Despite the recent advances in knowledge of MSCs biology, their biochemical molecular properties are still poorly defined. Ecto‐nucleoside triphosphate diphosphohydrolases (E‐NTPDases) ecto‐5′‐nucleotidase (eNT/CD73) widely expressed enzymes that hydrolyze extracellular nucleotides, generating an important cellular signaling cascade. Currently, studies evidenced...
The effects of trans-resveratrol (1) were evaluated in acute nociception models induced by capsaicin or glutamate mice, an attempt to further characterize its mechanism action. oral administration 1 (50 and 100 mg/kg) reduced significantly the licking behavior elicited (1.6 μg/paw) (10 μmol/paw). co-administration into mouse paw (200 μg/site) markedly prevented glutamate-induced licking, without affecting responses. In addition, intrathecal (it) injection (150 600 greatly caused capsaicin,...
Macrophages are myeloid cells that play an essential role in inflammation and host defense, regulating immune responses maintaining tissue homeostasis. Depending on the microenvironment, macrophages can polarize to two distinct phenotypes. The M1 phenotype is activated by IFN-γ bacterial products, displays inflammatory profile, while M2 IL-4 tend be anti-inflammatory or immunosupressive. It was observed DnaK from Mycobacterium tuberculosis has immunosuppressive properties, inducing a...
// Luis Felipe Campesato 1, 2, 3 , Ana Paula M. Silva 1 Luna Cordeiro 4 Bruna R. Correa 2 Fabio C.P. Navarro Rafael F. Zanin 5 Marina Marçola 6 Lilian T. Inoue Mariana L. Duarte Martina Molgora Pasqualini Matteo Massara Pedro Galante Romualdo Barroso-Sousa 7 Nadia Polentarutti Federica Riva 8 Erico Costa Alberto Mantovani 4, 9 Cecilia Garlanda and Anamaria A. Camargo Ludwig Institute for Cancer Research, São Paulo, Brazil Molecular Oncology Center, Hospital Sírio-Libanês, Graduate Program in...
Abstract In transplantation, donor dendritic cells (do-DCs) initiate the alloimmune response either by direct interaction with host T or transferring intact MHC to DCs. However, how do-DCs can be targeted for improving allograft survival is still unclear. Here we show CD103 + DCs are major do-DC subset involved in acute rejection of murine skin transplants. absence do-DCs, less MHC-II carried lymph nodes, fewer allogenic primed and prolonged. Incubation grafts anti-inflammatory mycobacterial...
Abstract Irritant contact dermatitis ( ICD ) is an inflammatory reaction caused by chemical toxicity on the skin. The P 2 X 7 receptor R a key mediator of cytokine release, which recruits immune cells to sites inflammation. We investigated role in croton oil C r O )‐induced using vitro and vivo approaches. was induced application mouse ear incubation murine macrophages dendritic DC s) with ATP . Infiltrating were identified flow cytometry, histology myeloperoxidase MPO determination. Effects...