A5038674020- Mosquito-borne diseases and control
- Biosensors and Analytical Detection
- SARS-CoV-2 and COVID-19 Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanoparticles: synthesis and applications
- Graphene and Nanomaterials Applications
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Cancer-related Molecular Pathways
- Calcium signaling and nucleotide metabolism
- Nanoparticle-Based Drug Delivery
- Viral Infections and Vectors
- Cell death mechanisms and regulation
- Metal complexes synthesis and properties
- Ion Channels and Receptors
- RNA Interference and Gene Delivery
- Magnetism in coordination complexes
- PARP inhibition in cancer therapy
- Immunotherapy and Immune Responses
- COVID-19 Impact on Reproduction
- COVID-19 and healthcare impacts
- Boron and Carbon Nanomaterials Research
- Liver physiology and pathology
- Sperm and Testicular Function
- Plasmonic and Surface Plasmon Research
Universidade Federal de Minas Gerais
2016-2025
University of Antofagasta
2019
City College of New York
2019
Ondokuz Mayıs University
2019
Fundação Oswaldo Cruz
2011-2013
Although used in medical applications for centuries, the development of nanotechnology has shed new light plethora possible and biological using gold-based nanostructures. Gold nanostructures are stable relatively inert systems, leading to low reatogenicity, biocompatibility general lack toxicity. Allied that, gold nanoparticles present optical electronic properties that have been exploited a range biomedical applications. In this review we discuss biologically relevant how they some...
Abstract Calcium (Ca 2+ ) is an essential signal transduction element involved in the regulation of several cellular activities and it required at various key stages cell cycle. Intracellular Ca crucial for orderly cycle progression plays a vital role proliferation. Recently, was demonstrated by vitro vivo studies that nucleoplasmic regulates growth. Even though mechanism which nuclear proliferation not completely understood, there are reports demonstrating activation tyrosine kinase...
Abstract Background Cellular entry of SARS-CoV-2 has been shown to rely on angiotensin-converting enzyme 2 (ACE2) receptors, whose expression in the testis is among highest body. Additionally, risk mortality seems higher male COVID-19 patients, and though much published since first cases COVID-19, there remain unanswered questions regarding impact testes potential consequences for reproductive health. We investigated testicular alterations non-vaccinated deceased COVID-19-patients, precise...
Insulin's metabolic effects in the liver are widely appreciated, but insulin's ability to act as a hepatic mitogen is less well understood. Because insulin receptor (IR) can traffic nucleus, and Ca(2+) signals within nucleus regulate cell proliferation, we investigated whether mitogenic result from activation of Ca(2+)-signaling pathways by IRs nucleus. Insulin-induced increases proliferation depended upon clathrin- caveolin-dependent translocation IR formation inositol 1,4,5,-trisphosphate...
This tutorial delves into the integration of plasmonic metasurfaces as cutting-edge tools for creating highly sensitive diagnostic assays tailored to neglected infectious diseases. Plasmonic provide a transformative approach diagnostics by addressing common limitations traditional methods, including slow results and high costs. explores their application in advancing cost-effective solutions manuscript covers complete cycle developing optimized, AI-driven metasurfaces, from...
Subcellular Ca(2+) signals control a variety of responses in the liver. For example, mitochondrial (Ca(mit)(2+)) regulates apoptosis, whereas nucleus cell proliferation. Because apoptosis and growth can be related, we investigated whether Ca(mit)(2+) also affects liver regeneration. The Ca(2+)-buffering protein parvalbumin, which was targeted to matrix fused green fluorescent protein, expressed SKHep1 line; vector called parvalbumin-mitochondrial targeting sequence-green (PV-MITO-GFP). This...
Abstract Background Adenosine triphosphate (ATP) is secreted from hepatocytes under physiological conditions and plays an important role in liver biology through the activation of P2 receptors. Conversely, higher extracellular ATP concentrations, as observed during necrosis, trigger inflammatory responses that contribute to progression injury. Impaired calcium (Ca 2+ ) homeostasis a hallmark acetaminophen (APAP)-induced hepatotoxicity, since induces mobilization intracellular Ca stocks, we...
Abstract The Flaviviridae virus family was named after the Yellow-fever , and latin term flavi means “of golden color”. Dengue, caused by Dengue (DENV), is one of most important infectious diseases worldwide. A sensitive differential diagnosis crucial for patient management, especially due to occurrence serological cross-reactivity other co-circulating flaviviruses. This became particularly with emergence Zika (ZIKV) in areas were DENV seroprevalence already high. We developed a specific...
In this work, flower-like molybdenum disulfide (MoS2) microspheres were produced with polyethylene glycol (PEG) to form MoS2-PEG. Likewise, gold nanoparticles (AuNPs) added MoS2-PEG/Au investigate its potential application as a theranostic nanomaterial. These nanomaterials fully characterized by scanning electron microscopy (SEM), transmission (TEM), X-ray diffraction (XRD), photoelectron spectroscopy (XPS), Fourier-transformed infrared (FTIR), cyclic voltammetry and impedance spectroscopy....
In this work, we demonstrated a tunable double anticrossing interaction resulting from the interplay between two LSPR modes and an SPP wave in all-metal pyramidal metasurface. The tuning is done as function of variation angle incidence input electric field. From anticrossing, it was that at certain angles incidence, intensity field obtained specific wavelengths strongly favored due to nature structures used, which consequently would benefit applications such SERS, shown manuscript....
Background: Calcium (Ca 2+ ) signaling within the nucleus is known to play a crucial role in cell proliferation.The aim of this study was investigate whether nuclear Ca buffering could improve antitumor effect X-rays therapy on Human Squamous Cell Carcinoma (HSCC).Methods: For these purpose, we developed an experimental protocol that simulated clinical radiotherapy and prevented bystander effects irradiation.HSCC, A431 line, submitted 10Gy cumulative alone (XR Cd 10Gy) or association with...
Gold nanoparticles enhance antibody-fluorescence detection by flow cytometry reducing the signal to noise ratio and improving cell biology assessments.