A5041676103- Bone Tissue Engineering Materials
- Liver Disease Diagnosis and Treatment
- Dental Implant Techniques and Outcomes
- Quantum Dots Synthesis And Properties
- Dental materials and restorations
- Renin-Angiotensin System Studies
- Liver physiology and pathology
- Collagen: Extraction and Characterization
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Phytochemistry Medicinal Plant Applications
- Periodontal Regeneration and Treatments
- COVID-19 and healthcare impacts
- biodegradable polymer synthesis and properties
- Pancreatitis Pathology and Treatment
- Receptor Mechanisms and Signaling
- COVID-19 Clinical Research Studies
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Healthcare Systems and Reforms
- Cardiac Arrhythmias and Treatments
- Advanced biosensing and bioanalysis techniques
- COVID-19 Impact on Reproduction
- Computational Drug Discovery Methods
- Polymer composites and self-healing
Universidade Federal de Minas Gerais
2012-2024
Howard Hughes Medical Institute
2011
Fundação Universitária de Cardiologia
2004
Universidade do Estado do Rio de Janeiro
1998-2003
Cleveland Clinic
2003
Polymer-drug conjugation is an attractive approach for target delivering insoluble and highly toxic drugs to tumor sites overcome the side-effects caused by cancer chemotherapy. In this study we designed synthesized novel polymer-drug-peptide conjugates improved specificity on targeting cells. Chemically modified polysaccharide, carboxymethylcellulose (CMC), was conjugated with doxorubicin (DOX) anticancer drug amide bonds dually biofunctionalized integrin-target receptor tripeptide (RGD)...
Angiotensin-(1–7) [Ang-(1–7)] has biological actions that can often be distinguished from those of angiotensin II (Ang II). Recent studies indicate the effects Ang-(1–7) are mediated by specific receptor(s). We now report partial characterization a new antagonist selective for Ang-(1–7), d -Pro 7 -Ang-(1–7). -Ang-(1–7) (50 pmol) inhibited hypertensive effect induced microinjection [4±1 vs 21±2 mm Hg, 25 pmol alone] into rostral ventrolateral medulla without changing Ang (16±2.5 19±2.5 Hg...
Subcellular Ca(2+) signals control a variety of responses in the liver. For example, mitochondrial (Ca(mit)(2+)) regulates apoptosis, whereas nucleus cell proliferation. Because apoptosis and growth can be related, we investigated whether Ca(mit)(2+) also affects liver regeneration. The Ca(2+)-buffering protein parvalbumin, which was targeted to matrix fused green fluorescent protein, expressed SKHep1 line; vector called parvalbumin-mitochondrial targeting sequence-green (PV-MITO-GFP). This...
Cementum is a mineralized tissue that lines the surface of tooth root enabling attachment periodontal ligament to and surrounding alveolar bone. Studies examining mechanisms involved in formation cementum have been hindered by an inability isolate culture cells required for production (cementoblasts). This study isolated characterized cementoblast derived from rat molar ligament. It was observed expressed F-Spondin, marker, while F-Spondin expression not other tissues such as gingival...
The palladium(II) complexes [Pd(2Bz4oT)Cl], [Pd(2Bz4mT)Cl], and [Pd(2Bz4pT)Cl] were prepared with N(4)-ortho- (H2Bz4oT) N(4)-meta- (H2Bz4mT) N(4)-para- (H2Bz4pT) tolyl-thiosemicarbazones derived from 2-benzoylpyridine. free thiosemicarbazones proved to be highly cytotoxic against Jurkat, HL60 the resistant HL60.Bcl-X(L) leukemia cell lines at nanomolar concentrations, but much less HepG2human hepatoma cells. Upon coordination activity all studied decreases. However, high cytotoxicity of...
Abstract The development of polymer/bioactive glass has been recognized as a strategy to improve the mechanical behavior bioactive glass‐based materials. Several studies have reported systems based on glass/biopolymer composites. In this study, we developed composite system nanoparticles (BGNP), obtained by modified Stöber method. We also new chemical route obtain aqueous dispersive biodegradable polyurethane. production polyurethane/BGNP scaffolds intending combine biocompatibility,...
Abstract: Herein, for the first time, we demonstrated that novel biofunctionalized semiconductor nanomaterials made of Cd-containing fluorescent quantum dot nanoconjugates with surface capped by an aminopolysaccharide are not biologically safe clinical applications. Conversely, ZnS-based proved to be noncytotoxic, considering all parameters investigated. The results in vitro cytotoxicity were remarkably dependent on chemical composition (CdS or ZnS), nature cell (human cancerous and...
Background The angiotensin-I converting enzyme (ACE) plays a central role in the renin-angiotensin system, acting by hormone to active peptide angiotensin-II (Ang-II). More recently, ACE was shown act as receptor for Ang-II, and its expression level demonstrated be higher melanoma cells compared their normal counterparts. However, function that an Ang-II has not been defined yet. Aim Therefore, our aim examine of tumor cell proliferation migration. Results We found upon binding ACE,...
Bioactive glass/polymer hybrids are promising materials for biomedical applications because they combine the bioactivity of these glasses with flexibility polymers. In this work it was evaluated effect increasing PVA content on structural characteristics and mechanical properties hybrid. The were prepared 70 wt. (%) SiO2-30 CaO fractions 20 to 60 by sol-gel method. characterization done FTIR, SEM compression tests. To reduce acidic character due catalysts added, different neutralization...
BACKGROUND: Since February 2020, data on the clinical features of patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and their evolution have been gathered intensively discussed, especially in countries with dramatic dissemination this disease. OBJECTIVE: To assess Brazilian SARS-CoV-2 analyze its local epidemiological features. DESIGN AND SETTING: Observational retrospective study conducted using from an official electronic platform for recording confirmed...
In this study, our aims were to investigate transient receptor potential melastatin-8 channels (TRPM8) involvement in rotundifolone induced relaxation the mesenteric artery and increase understanding of role these thermosensitive TRP vascular tissue. Thus, message protein levels TRPM8 measured by semi-quantitative PCR western blotting superior arteries from 12 week-old Spague-Dawley (SD) rats. Isometric tension recordings evaluated relaxant response rings also performed. Additionally,...
Many human diseases, including metabolic, immune, and central nervous system disorders, as well several types of cancers, are the consequence an important alteration in lipid-related metabolic biomolecules. Although recognized that one most hallmarks cancer cells is deregulation lipid metabolism, multiple complex signaling pathways poorly understood yet. Thus, this research, novel nanoconjugates made ZnS quantum dots (QDs) were directly synthesized aqueous media using phosphoethanolamine...
Multiple opinion-based communications have highlighted the actions of Brazilian government during pandemic. Nevertheless, none appraised public data to identify factors associated with worsening healthcare system.To analyze and collate from health treasury information systems in order understand escalating process weakening welfare since beginning severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.Secondary study conducted using multiple databases administered by federal...
esde os primórdios da rádio e quimioterapia muito se tem investido em estratégias que levem o paciente à cura do câncer.Promissores alvos terapêuticos têm sido desenvolvidos, como alguns fármacos oriundos de produtos naturais peptídeos sintéticos.Várias frentes pesquisas no mundo
Abstract Bioactive ceramics have interesting properties from the biological standpoint, but their effects on cellular events remain partially unknown. In current work, we investigated viability, proliferation, and metabolic activity of rat primary osteoblasts in contact with four different samples: type I collagen, bioactive glass‐coated collagen (GC), both samples submitted to immersion for 5 days a simulated body fluid. The glass coating was obtained sol‐gel process. cell alkaline...
A anomalia de Ebstein é uma doença rara, embora seja a malformação mais comum da valva tricúspide. associação com outras síndromes e anomalias extracardíacas muito incomum matéria poucos relatos caso. Apresenta-se um caso diagnóstico pré-natal em paciente síndrome Down.
The cementum, a mineralized tissue lining the tooth root surface, is required for development of functional periodontal ligament. presence healthy cementum considered to be an important criterion predictable restoration tissues lost as consequence disease. Despite importance general oral health, very little known about cells responsible formation cementoblasts. aim this study was examine effect ionic products from dissolution bioactive glass with 60% silica ( BG60S ) on behavior...
The cytocompatibility of synthetic hydroxyapatite/collagen composites alone or doped with Zn+2 was tested by using primary culture osteoblasts. hydroxyapatite (HAP) synthesized having calcium hydroxide and orthophosphoric acid as precursors. A new HAP composite developed adding 1.05 w% Zn(NO3)2.6H2O forming HAPZn. pure type I collagen (COL) obtained from bovine pericardium enzymatic digestion method. HAP/COL HAPZn/COL were characterized SEM/EDS. cell viability alkaline phosphatase activity...