A5009056666- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Renin-Angiotensin System Studies
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- Thermoregulation and physiological responses
- Biochemical effects in animals
- Neurotransmitter Receptor Influence on Behavior
- Nitric Oxide and Endothelin Effects
- Cannabis and Cannabinoid Research
- Diet and metabolism studies
- Diabetes Treatment and Management
- Mitochondrial Function and Pathology
- Pharmacological Receptor Mechanisms and Effects
- Dietary Effects on Health
- Regulation of Appetite and Obesity
- Youth, Drugs, and Violence
- Gastroesophageal reflux and treatments
- Neuroendocrine regulation and behavior
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Apelin-related biomedical research
Universidade Federal de Minas Gerais
2014-2024
University of Nebraska Medical Center
2016-2020
Max Delbrück Center
2016
Cleveland Clinic
2003
Universidade Federal de São Paulo
1997-1999
Universidade de São Paulo
1989-1995
Universidade Paulista
1994
Universidade Estadual Paulista (Unesp)
1992
Activation of carotid chemoreceptors with intravenous potassium cyanide (KCN) produces increases in arterial pressure, bradycardia, and tachypnea. In the present study, we activated KCN neurotransmission chemoreceptor reflex into commissural nucleus tractus solitarii (NTS) was blocked phosphonovaleric acid (AP-5), an N-methyl-D-aspartate (NMDA)-selective antagonist. The aim this study to evaluate involvement NMDA receptors cardiovascular respiratory responses produced by activation...
Angiotensin-(1–7) [Ang-(1–7)] has biological actions that can often be distinguished from those of angiotensin II (Ang II). Recent studies indicate the effects Ang-(1–7) are mediated by specific receptor(s). We now report partial characterization a new antagonist selective for Ang-(1–7), d -Pro 7 -Ang-(1–7). -Ang-(1–7) (50 pmol) inhibited hypertensive effect induced microinjection [4±1 vs 21±2 mm Hg, 25 pmol alone] into rostral ventrolateral medulla without changing Ang (16±2.5 19±2.5 Hg...
Cardiovascular responses to chemoreflex activation by potassium cyanide (KCN, 20 microgram/rat iv) were analyzed before and after the blockade of ionotropic or metabotropic receptors into nucleus solitary tract (NTS) awake rats. Microinjection antagonists [6,7-dinitroquinoxaline-2,3-dione kynurenic acid (Kyn)] lateral commissural NTS (NTSlat), midline (NTSmid), both (NTSlat+mid), produced a significant increase in basal mean arterial pressure, pressor response was only partially reduced,...
Central infusion of Ang II (angiotensin II) has been associated with increased sympathetic outflow resulting in neurogenic hypertension. In the present study, we appraised whether chronic increase central activates paraventricular nucleus hypothalamus (PVN) elevated tone and altered baro- chemoreflexes. Further, evaluated contribution HIF-1α (hypoxia-inducible factor-1α), a transcription factor involved enhancing expression N-methyl-D-aspartate receptors thus glutamatergic-mediated from PVN....
This study evaluated the physiological importance of Angiotensin-(1-7) receptor Mas on reflex control circulation. Experiments were performed in male Mas-knockout (Mas-KO) and Wild Type (WT) conscious mice (12-20 wk age). Baroreceptor was by bradycardic response induced phenylephrine (0.25 μg/5 μl, i.v.). Bezold-Jarisch phenylbiguanide (0.5 i.v.) chemoreflex potassium cyanide (2.5 Baseline mean arterial pressure higher Mas-KO (n=14) as compared with WT (n=18) (118±1 mmHg vs. 109±2 mmHg);...
The present study aimed to investigate whether running performance in different environments is dependent on intact arterial baroreceptor reflexes. We also assessed the exercise-induced cardiovascular and thermoregulatory responses animals lacking baroafferent signals. To accomplish these goals, male Wistar rats were subjected sinoaortic denervation (SAD) or sham surgery (SHAM) had a catheter implanted into ascending aorta record pressure telemetry sensor abdominal cavity core temperature....
The present study investigated whether the effects of central cholinergic stimulation on thermoregulation during exercise are modulated by arterial baroreceptors. Wistar rats were submitted to sinoaortic denervation (SAD) or sham (SHAM) and then fitted with a chronic guide cannula into lateral cerebral ventricle. After 2 weeks, catheter was implanted ascending aorta, temperature sensor peritoneal cavity. Two days later, treadmill at 18 m/min until fatigued. Thermoregulatory cardiovascular...
The effects of blocking ventromedial hypothalamic nucleus (VMH) muscarinic cholinoceptors on cardiovascular responses were investigated in running rats. Animals anesthetized with pentobarbital sodium and fitted bilateral cannulae into the VMH. After recovering from surgery, rats familiarized to a treadmill. animals then had polyethylene catheter implanted left carotid artery measure blood pressure. Tail skin temperature (Ttail), heart rate, systolic, diastolic mean arterial pressure measured...
The cardiovascular effects of substance P (SP) microinjections in the nucleus tractus solitarii (NTS) were evaluated conscious rats. We chose this model because it is an effective way to access some neurotransmitters NTS without inconvenience blunting pathways with anesthetic agents or removing forebrain projections by decerebration. responses SP injections also after chronic nodose ganglionectomy. found that, rats, into induced hypertension and tachycardia. Unilateral bilateral caused a...
The angiotensin-converting enzyme 2 (ACE2)/angiotensin (Ang)-(1-7)/Mas axis could modulate the heart rate (HR) and blood pressure variabilities (BPV) which are important predictors of cardiovascular risk provide information about autonomic modulation system. Therefore we investigated effect Mas deficiency on in wild type Mas-knockout (KO) mice.Blood was recorded at high sample (4000 Hz). Stationary sequences 200-250 beats were randomly chosen. Frequency domain analysis HR BPV performed with...
AbstractThe present study evaluated the effects of a low-protein diet (LP, 6% protein) on cardiovascular reflexes Male Fisher rats. Three experimental groups, and their respective controls (15% protein), were used. (1) Baroreceptor reflex (BAR); (2) Bezold-Jarisch (BJR); (3) Prazosin treated. Dietary restriction began after weaning (three weeks) lasted for period five weeks, which animals subjected to protocols. The BAR group was through injections phenylephrine (0.55.0 μg/Kg, i.v.) sodium...
The present study investigated the role of dorsomedial hypothalamus (DMH) on cardiovascular and behavioural responses chemoreflex activation in conscious rats. arterial was activated by potassium cyanide (KCN, 40 μg, i.v.) before after bilateral microinjection lidocaine (2%) or kynurenic acid (2.7 nmol) into DMH. Locomotor activity measured to assess response. Bilateral DMH produced a significant reduction pressor response induced (+51 ± 4 versus +34 5 mmHg, n = 5, P < 0.05). A similar also...
Alternative splicing (AS) may increase the number of proteoforms produced by a gene. Alzheimer's disease (AD) is neurodegenerative with well-characterized AS proteoforms. In this study, we used proteogenomics strategy to build customized protein sequence database and identify orthologous between humans mice on publicly available shotgun proteomics (MS/MS) data corpus callosum (CC) olfactory bulb (OB). Identical proteotypic peptides six were found in both species: PKM1 (gene
What is the central question of this study? In study, we sought to investigate whether cardiovascular responses peripheral chemoreflex activation rats recovered from protein restriction are related AT1 receptors. main finding and its importance? This study highlights fact that angiotensinergic mechanisms activated by receptors do not support increased KCN in restriction. Also, found led resting ventilation adult rats, even after recovery. The effects a low-protein diet followed recovery on...