A5061963985- Estrogen and related hormone effects
- Sperm and Testicular Function
- Helicobacter pylori-related gastroenterology studies
- Hormonal and reproductive studies
- Prostate Cancer Treatment and Research
- Parasites and Host Interactions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hypothalamic control of reproductive hormones
- Advancements in Transdermal Drug Delivery
- Pesticide Exposure and Toxicity
- Animal Nutrition and Physiology
- Vitamin D Research Studies
- Comparative Animal Anatomy Studies
- Pesticide and Herbicide Environmental Studies
- Effects and risks of endocrine disrupting chemicals
- Galectins and Cancer Biology
- Acne and Rosacea Treatments and Effects
- Electrolyte and hormonal disorders
- Dermatology and Skin Diseases
- Cancer, Lipids, and Metabolism
- COVID-19 Clinical Research Studies
- Bat Biology and Ecology Studies
- Animal Behavior and Reproduction
- Reproductive biology and impacts on aquatic species
- Ion Transport and Channel Regulation
Universidade Federal de Minas Gerais
2015-2025
Hospital das Clínicas da Universidade Federal de Minas Gerais
2020
Hudson Institute
2018
John Wiley & Sons (United States)
2018
Universidade de São Paulo
2009-2011
University of Illinois Urbana-Champaign
2001-2005
Morpho (United States)
2002
Centro Universitário de Belo Horizonte
1992
The aim of the present study was to determine mechanisms involved in estrogen actions cultured rat Sertoli cells. RT-PCR detected transcripts for receptors ESR1 and ESR2 immature cells testis 15-, 28-, 120-day-old rats. expression confirmed by immunofluorescence Western blot. Immunohistochemistry with cryosections testes from adult rats revealed that is Sertoli, Leydig, some peritubular myoid cells, multiple cell types, including germ Treatment 17beta-estradiol (E(2)) induced a translocation...
Background information . Efferent ductules reabsorb more than 90% of the rete testis fluid, a process that involves ion transporters and AQP (aquaporin) water channels. Oestrogen has been shown to modulate expression involved in this activity, but reports regulation male tract have confounding. To understand better AQP1 AQP9, we investigated their rat efferent initial segment epididymis after treatment with pure antioestrogen ICI 182,780 or bilateral duct ligation, castration, followed by...
This work aims to investigate the influence of formation ion pairing between all-trans retinoic acid (RA) and a lipophilic amine (stearylamine; STE) on drug encapsulation efficiency (EE) stability solid lipid nanoparticles (SLNs). The SLNs were characterized for EE size. particle size significantly improved reduced, respectively, when surfactant or co-surfactant concentration increased. However, while formulation without STE allowed only 13% RA encapsulation, RA-STE-loaded was 94%. studies...
The emergence of life-threatening zoonotic diseases caused by betacoronaviruses, including the ongoing coronavirus disease 19 (COVID-19) pandemic, has highlighted need for developing preclinical models mirroring respiratory and systemic pathophysiological manifestations seen in infected humans. Here, we showed that C57BL/6J wild-type mice intranasally inoculated with murine betacoronavirus hepatitis 3 (MHV-3) develop a robust inflammatory response leading to acute lung injuries, alveolar...
The density of antral gastrin (G)- and somatostatin (D)-immunoreactive cells the contents were investigated in endoscopic biopsy specimens from patients with duodenal ulcer before after eradication Helicobacter pylori. After H. pylori both concentration (p = 0.0002) D-cell 0.01) increased significantly. Conversely, although number G-cells was unchanged, serum 0.001) decreased oxyntic D-cells did not change These results strongly suggest that hypergastrinaemia observed pylori-positive may be...
Insulin's metabolic effects in the liver are widely appreciated, but insulin's ability to act as a hepatic mitogen is less well understood. Because insulin receptor (IR) can traffic nucleus, and Ca(2+) signals within nucleus regulate cell proliferation, we investigated whether mitogenic result from activation of Ca(2+)-signaling pathways by IRs nucleus. Insulin-induced increases proliferation depended upon clathrin- caveolin-dependent translocation IR formation inositol 1,4,5,-trisphosphate...
The estrogen receptor-α (ERα) knockout mouse (αERKO) lacks ERα throughout development; therefore, an adult model for the study of effects in male mice was recently developed using antiestrogen ICI 182,780. However, differences between species have been noted during immunostaining tract as well response to treatments with antiestrogens. Therefore, we rat test, another species, hypothesis that regulates fluid reabsorption efferent ductules. Estrogen receptor blocked 182,780 100–150 days. Male...
Abstract Male rats, 30 d old, were treated with the antiestrogen ICI 182,780 (3–150 d) to determine sequences of events leading testicular atrophy and infertility. Plasma testosterone LH concentrations unchanged. induced dilation efferent ductules as early 3 post treatment, increased over time, resulting in an overall increase 200% tubule diameter. A gradual reduction height ductule epithelium was observed; however, microvilli up 73 but subsequently decreased. transient lysosomes nonciliated...
Estrogen receptors, in addition to the androgen receptor (AR), are expressed at high levels efferent ductules of male reproductive tract and it is now well recognized that estrogen (ER) α required for maintenance normal structure function ductules. However, little known regarding hormonal regulation receptors themselves male. In present study, ductule ligation castration, followed by replacement with testosterone, dihydro-testosterone (DHT) or estradiol was used investigate relative...
A local renin–angiotensin system has been described in several organs, including the ovary; however, data indicating a role for angiotensin II induction of ovulation are controversial. We have previously shown presence novel peptide, angiotensin-(1–7) [Ang-(1–7)], rat ovary and its effect on steroidogenesis. The objective present study was to determine whether Ang-(1–7) plays ovulation. first determined distribution receptor Mas rabbit ovaries by immunohistochemistry. Angiotensin-(1–7)...
The antiestrogen ICI 182,780 has been used successfully as an alternative experimental model for the study of estrogen action in rodent adult male reproductive tract. Although causes severe alterations testicular and efferent ductule morphology function, effects on expression androgen receptors have not shown.In present study, rats were treated with 7 to 150 days, evaluate time-response treatment pattern ERalpha, ERbeta AR protein ductules. localized using immunohistochemistry.ERalpha,...
Abstract Background Fluid homeostasis is critical for normal function of the male reproductive tract and aquaporins (AQP) play an important role in maintenance this water ion balance. Several AQPs have been identified male, but their regulation not fully comprehended. Hormonal appears to be dependent on steroid region. AQP9 displays unique hormonal efferent ductules epididymis, as it regulated by both estrogen dihydrotestosterone (DHT) ductules, only DHT initial segment epididymis. Recent...
Learning Cell Biology is challenging for both sighted and visually impaired students due to its abstract nature reliance on bidimensional depictions in textbooks, which often fail capture the biological complexity of cell structures functions. To implement inclusive learning environments address shortage materials students, this work aimed design, apply, evaluate tools based digital technologies, using principles Educational Design Research. 3D models representing membranes were created...
The COVID-19 pandemic caused by the SARS-CoV-2 (β-CoV) betacoronavirus has posed a significant threat to global health. Despite availability of vaccines, virus continues spread, and there is need for alternative strategies alleviate its impact. Vitamin D, secosteroid hormone best known role in bone health, exhibits immunomodulatory effects certain viral infections. Here, we have shown that bioactive vitamin D (calcitriol) limits vitro replication murine coronaviruses MHV-3 MHV-A59....