A5076000554- Inhalation and Respiratory Drug Delivery
- Amyotrophic Lateral Sclerosis Research
- Neonatal Respiratory Health Research
- Neurogenetic and Muscular Disorders Research
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Lipid Membrane Structure and Behavior
- Moyamoya disease diagnosis and treatment
- Air Quality and Health Impacts
- Streptococcal Infections and Treatments
- Prion Diseases and Protein Misfolding
- Nanoparticles: synthesis and applications
- Advanced Drug Delivery Systems
- Neurofibromatosis and Schwannoma Cases
- Nanoparticle-Based Drug Delivery
- Vascular Malformations Diagnosis and Treatment
- Advancements in Transdermal Drug Delivery
- Neurological diseases and metabolism
- Extracellular vesicles in disease
- Acoustic Wave Resonator Technologies
- Asthma and respiratory diseases
- Vascular anomalies and interventions
- Medical History and Innovations
- Transcranial Magnetic Stimulation Studies
- Cystic Fibrosis Research Advances
Southmead Hospital
2023-2025
Stanford Health Care
2024
Armed Forces Medical College
2023
North Bristol NHS Trust
2023
Stanford Medicine
2022
King's College London
2008-2020
MRC Centre for Environment and Health
2019
Patna Medical College and Hospital
2017
Frenchay Hospital
2012-2013
Queen Elizabeth Hospital
2006
Replicable risk factors for ALS include increasing age, family history and being male. The male: female ratio has been reported as between 1 3. We tested the hypothesis that sex changes with age in a population register covering south-east of England. before after 51 years was compared using Z-test proportions. Kendall's tau used to assess relationship group incidence prevalence data. Publicly available data from Italian Irish registers were results. There significant difference proportion...
<i>Background/Aims:</i> We aimed to estimate the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in South East England. The reported ALS varies between 0.44 3.2 per 100,000 person years. This can partly be explained by differences design diagnostic criteria used. There is little population data concerning England, particularly East. <i>Methods:</i> A study South-East England (total population: 2,890,482) was carried out multiple sources including our...
Abstract Studies have emphasised the importance of combustion-derived particles in eliciting adverse health effects, especially those produced by diesel vehicles. In contrast, few investigations explored potential toxicity derived from tyre and brake wear, despite their significant contributions to total roadside particulate mass. The objective this study was compare relative compositionally distinct abrasion dust (BAD) exhaust (DEP) a cellular model that is relevant human airways. Although...
To characterise a biorelevant simulated lung fluid (SLF) based on the composition of human respiratory tract lining fluid. SLF was compared to other media which have been utilized as simulants in terms structure, biocompatibility and performance inhalation biopharmaceutical assays. The structure investigated using cryo-transmission electron microscopy, photon correlation spectroscopy Langmuir isotherms. Biocompatibility with A549 alveolar epithelial cells determined by MTT assay,...
OBJECTIVE The post-bypass stroke risk factors and long-term outcomes of moyamoya patients are not well documented. Therefore, the authors studied 30-day risks patients’ physical, functional, social well-being. METHODS This was a single-institution combined disease (MMD) database interrogation questionnaire study. From 1991 to 2014, 1250 revascularization procedures (1118 direct bypasses, 132 indirect bypasses) were performed in 769 patients. Completed questionnaires received from available...
<i>Background:</i> Amyotrophic lateral sclerosis (ALS) is a degenerative disease of motor neurons that causes progressive paralysis and eventually results in death from respiratory failure. Environmental factors trigger ALS might result pattern geographical clustering cases. We tested this hypothesis using the South-East England population register, which covers south-east London, Kent parts neighbouring counties. <i>Methods:</i> The register’s catchment area was...
To date, in vitro studies assessing the pulmonary toxicity of inhaled particles have provided poor correlation with vivo results. We explored whether this discrepancy reflected cellular adaptations cells cultured under atmospheric oxygen concentrations (21%) compared alveolar (100 mm Hg, ~ 13%) and blunted responses to nanoparticle challenge. At 21% oxygen, A549 had augmented intracellular glutathione concentrations, evidence increased tolerance CuO nanoparticles, reduced reactive species...
The dissolution of inhaled drug particles in the lungs is a challenge to model using biorelevant methods terms (i) collecting respirable emitted aerosol fraction and dose, (ii) presenting this small volume medium that representative lung lining fluid, (iii) measuring low concentrations released. We report developments methodology for each these steps utilize mechanistic silico modeling evaluate vitro profiles context plasma concentration-time profiles. PreciseInhale delivery system was used...
We aimed to assess whether rural residence is associated with amyotrophic lateral sclerosis in the south-east of England using a population based register. Previous studies different populations have produced contradictory findings. Residence defined by London borough or non-metropolitan district at time diagnosis was recorded for each incident case South-East ALS Register between 1995 and 2005. Each 26 boroughs districts catchment area register classified according density. Age-...
Although foamy macrophages (FMΦ) are commonly observed during nonclinical development of medicines for inhalation, there no accepted criteria to differentiate adaptive from adverse FMΦ responses in drug safety studies. The purpose this study was develop a multiparameter vitro assay strategy and characterize different mechanisms drug-induced FMΦ. Amiodarone, staurosporine, poly(vinyl acetate) nanoparticles were used induce distinct phenotypes J774A.1 cells, which then compared with negative...
The aim of the study was to use in silico and vitro techniques evaluate whether a triple formulation antiretroviral drugs (tenofovir, darunavir, dapivirine) interacted with P-glycoprotein (P-gp) or exhibited any other permeability-altering drug-drug interactions colorectal mucosa. Potential drug P-gp were screened initially using molecular docking, followed by dynamics simulations analyze identified drug-transporter interaction more mechanistically. transport tenofovir, dapivirine...
Progress to the clinic may be delayed or prevented when vacuolated "foamy" alveolar macrophages are observed during non-clinical inhalation toxicology assessment. The first step in developing methods study this response vitro is characterize macrophage cell lines and their drug exposures.Human (U937) rat (NR8383) primary obtained by bronchoalveolar lavage were characterized using high content fluorescence imaging analysis quantification of viability, morphometry, phospholipid neutral lipid...
Objectives: This study delineates the intricate details of seven pituitary transposition techniques and evaluates their clinical application selection in endoscopic endonasal approach to retrosellar retroinfundibular area.