A5074036434- Advancements in Transdermal Drug Delivery
- Therapeutic Uses of Natural Elements
- Advanced Drug Delivery Systems
- Drug Solubulity and Delivery Systems
- Essential Oils and Antimicrobial Activity
- Bee Products Chemical Analysis
- Pickering emulsions and particle stabilization
- Enzyme function and inhibition
- Nitric Oxide and Endothelin Effects
- Pacific and Southeast Asian Studies
- Sirtuins and Resveratrol in Medicine
- Analytical Methods in Pharmaceuticals
- Pharmaceutical studies and practices
- Ocular Surface and Contact Lens
- Medical and Biological Ozone Research
- Enzyme Catalysis and Immobilization
- Periodontal Regeneration and Treatments
- Textile materials and evaluations
- Autophagy in Disease and Therapy
- Linguistics and Language Studies
- Ethnobotanical and Medicinal Plants Studies
- Glaucoma and retinal disorders
- Skin Protection and Aging
- Geological and Geophysical Studies Worldwide
- Historical Education and Society
University of Pittsburgh
2024
Universidade do Porto
2007-2022
Rede de Química e Tecnologia
2012-2021
University of Coimbra
2011-2012
Hydrogels with high affinity for carbonic anhydrase (CA) inhibitor drugs have been designed trying to mimic the active site of physiological metallo-enzyme receptor. Using hydroxyethyl methacrylate (HEMA) as backbone component, zinc methacrylate, 1- or 4-vinylimidazole (1VI 4VI), and N-hydroxyethyl acrylamide (HEAA) were combined at different ratios reproduce in hydrogels cone-shaped cavity CA, which contains a Zn2+ ion coordinated three histidine residues. 4VI resembles functionality better...
Recently, studies on the by-products from food industry, such as passion fruit seeds, have significantly increased, these can an added value, due to their properties, potential antioxidant activity. This study was conducted determine presence of piceatannol and resveratrol in various extracts (Passiflora edulis) seeds Madeira Island a commercial oil used reference. The that were obtained by traditional Soxhlet method with ethanol acetone did not reveal two stilbenes, resveratrol. However,...
Colocasia esculenta (L.) Shott, commonly called taro, is an ancient species selected for its edible tuber. Its huge "elephant ear" like leaves are also consumed in sauces and stews or as soups. Forty-one phenolic metabolites (11 hydroxycinnamic acid derivatives 30 glycosylated flavonoids) were identified by high-performance liquid chromatography-diode array detection-electrospray ionization/mass spectrometry (HPLC-DAD-ESI/MS(n)) the of two C. varieties cultivated Azores Islands. To our...
Emulsions are the most common form of skin care products. However, these systems may exhibit some instability. Therefore, when developing emulsions for topical application it is interesting to verify whether they have suitable physical and mechanical characteristics further assess their stability. The aim this work was study stability emulsion systems, which varied in proportion emulsifying agent cetearyl alcohol (and) sodium lauryl sulfate (LSX), nature oily phase (decyl oleate,...
A simple reverse-phase (RP) high performance liquid chromatography (HPLC) method was developed and validated, according to the International Harmonisation Guidelines (ICH), for determination of risperidone (RISP) from solid lipid nanoparticles (SLN). Chromatographic runs were performed on a RP-C18 column, using an isocratic mobile phase methanol, acetate buffer (0.05 M; pH 4.6) triethylamine (60:40:0.02, v/v/v). The flow rate 1 ml/min, run time 10 min RISP absorbance measured at 280 nm, UV...
Background: Miconazol, an antimycotic drug, is commonly formulated into semisolid formulations designed to be applied in the oral cavity treat candidiasis. However, given its limited aqueous solubility, permeation through biological membranes low and therefore activity also limited. Cyclodextrins (CDs) have been widely used increase solubility stability of poorly water-soluble drugs. Aim: The aim this study formulate a gel containing inclusion complex between modified CD,...
Freqüentemente recorre-se à produção de sistemas gastrorretentivos para modular a liberação fármacos partir farmacêuticos com vistas ao aumento do tempo permanência fármaco no trato gastrointestinal. Umas das estratégias mais interessantes passa pela flutuantes. Estes podem ser classificados em dois grupos: flutuantes efervescentes e não-efervecentes. Neste artigo apresenta-se uma revisão bibliográfica que tem sido produzido nesta área nos últimos anos.
Abstract Portuguese gypsum deposits utilized by the cement industry were characterized mineralogically, chemically and technologically for possible application in dermocosmetics. The studied (Loulé, Óbidos Soure) correspond to small outcrops diapiric anticline areas. In principle, they represent gypsites which are white, generally of higher quality traditional applications ( e.g. white cement), or greyish, not adequate cements mortars. analytical methods used characterize materials wet...
Abstract Background The bi‐directional autophagy and inflammation network becomes progressively dysregulated with age, systemic as a biomarker of this dysregulation including in Alzheimer’s Disease (AD). We hypothesize that interventions which target the shared feature biology aging AD, via regulation autophagy‐inflammation network, will prevent conversion to disease pathogenesis AD well improve healthspan longevity populations. While previous studies report benefits mTOR inhibition...
It has been reported that the antioxidant activity of passion fruit seeds oil is comparable to ascorbic acid, due a high content polyphenols such as stilbenes. The aim this study was use residues from Madeira Island food industry produce seed extracts by Soxhlet and Ultrasound methods, using acetone ethanol, in order determine presence stilbenes (piceatannol resveratrol) High-performance liquid chromatography (HPLC). obtained ultrasound method showed piceatannol resveratrol content, while...