A5081925088- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Advancements in Transdermal Drug Delivery
- Orthopaedic implants and arthroplasty
- Glaucoma and retinal disorders
- Electrospun Nanofibers in Biomedical Applications
- Enzyme function and inhibition
- Graphene and Nanomaterials Applications
- Wound Healing and Treatments
- Drug Solubulity and Delivery Systems
- Nitric Oxide and Endothelin Effects
- Hemoglobin structure and function
- Hemostasis and retained surgical items
- Supramolecular Self-Assembly in Materials
- Advanced Cellulose Research Studies
- Enzyme-mediated dye degradation
- Titanium Alloys Microstructure and Properties
- Synthesis and biological activity
- Intraocular Surgery and Lenses
- Phenothiazines and Benzothiazines Synthesis and Activities
- Proteins in Food Systems
- Lignin and Wood Chemistry
Universidade Federal do Paraná
2015-2023
University of Coimbra
2011-2023
Universidade Federal do ABC
2017
Universidade de Santiago de Compostela
2011-2012
Universidade do Porto
2008-2010
Hydrogels with high affinity for carbonic anhydrase (CA) inhibitor drugs have been designed trying to mimic the active site of physiological metallo-enzyme receptor. Using hydroxyethyl methacrylate (HEMA) as backbone component, zinc methacrylate, 1- or 4-vinylimidazole (1VI 4VI), and N-hydroxyethyl acrylamide (HEAA) were combined at different ratios reproduce in hydrogels cone-shaped cavity CA, which contains a Zn2+ ion coordinated three histidine residues. 4VI resembles functionality better...
Polymeric micelles of single and mixed poloxamines (Tetronic) were evaluated regarding their ability to host the antiglaucoma agent ethoxzolamide (ETOX) for topical ocular application. Three highly hydrophilic varieties poloxamine (T908, T1107 T1307) a medium variety (T904), possessing similar number propylene oxide units but different contents in ethylene oxide, chosen study. The critical micellar concentration cloud point 0.9 per cent NaCl slightly greater than values predicted from...
The use of biodegradable polymers in regenerative tissue engineering and bone implants is increasingly practiced the biomedical area due to their good mechanical properties, biocompatibility complete degradation living organisms, without adverse side effects. Poly (l-lactic acid) (PLLA) a polymer, largely used bioengineering, although features such as high rigidity hydrophobicity limit its some areas. aim this work was investigate synthesis PLLA PLLA-3-Arm (a copolymer glycerol) through bulk...
The use of polymeric materials in biomedical applications has been growing exponentially. This phenomenon is due to progress areas such as science, tissue engineering, pharmaceutical technology and combined medical devices. In particular, the development concepts involving polymers that react external stimuli raised an increasing interest investigation products complement devices formulations drug delivery. stimulus-sensitive have ability respond variations surrounding environment, examples...
Background: Miconazol, an antimycotic drug, is commonly formulated into semisolid formulations designed to be applied in the oral cavity treat candidiasis. However, given its limited aqueous solubility, permeation through biological membranes low and therefore activity also limited. Cyclodextrins (CDs) have been widely used increase solubility stability of poorly water-soluble drugs. Aim: The aim this study formulate a gel containing inclusion complex between modified CD,...
Amostras de PEEK -poli (éter-éter-cetona) foram revestidas com titânio através do processo pulverização térmica por chama utilizando o gás nitrogênio ou argônio como transporte.Os revestimentos caracterizados microscopia óptica electrônica varredura, espectroscopia raios X dispersão em energia (EDS) e difração raios-X (DRX).Ensaios tribologia realizados sobre os Titânio (Ti) um desgaste abrasivo foi identificado ambas as amostras.A bioatividade da superfície revestimento das amostras...