A5007717519- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- Essential Oils and Antimicrobial Activity
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Bee Products Chemical Analysis
- Olfactory and Sensory Function Studies
- Biosimilars and Bioanalytical Methods
- Dermatology and Skin Diseases
- Pharmaceutical studies and practices
- Protein purification and stability
- Hematopoietic Stem Cell Transplantation
- Congenital heart defects research
- Fatty Acid Research and Health
- Metabolomics and Mass Spectrometry Studies
- Biotechnology and Related Fields
- Tracheal and airway disorders
- Transgenic Plants and Applications
- Cardiac Fibrosis and Remodeling
- Coconut Research and Applications
- Blood transfusion and management
Fernando Pessoa University
2014-2024
Universidade do Porto
2015-2024
Tribhuvan University
2024
Portuguese Sea and Atmosphere Institute
2024
Rede de Química e Tecnologia
2019-2023
Gladstone Institutes
2018-2021
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2018-2020
Hospital Pedro Hispano
2020
African Union
2020
University of California, San Francisco
2018
Elevations in cytosolic free calcium concentration ([Ca(2+)](cyt)) constitute a fundamental signal transduction mechanism eukaryotic cells, but the molecular identity of Ca(2+) channels initiating this plants is still under debate. Here, we show by pharmacology and loss-of-function mutants that tobacco Arabidopsis, glutamate receptor-like (GLRs) facilitate influx across plasma membrane, modulate apical [Ca(2+)](cyt) gradient, consequently affect pollen tube growth morphogenesis....
Rivastigmine is a drug commonly used in the management of Alzheimer’s disease that shows bioavailability problems. To overcome this, use nanosystems, such as nanostructured lipid carriers (NLC), administered through alternative routes seems promising. In this work, we performed double optimization rivastigmine-loaded NLC formulation for direct delivery from nose to brain using quality by design (QbD) approach, whereby target product profile (QTPP) was requisite delivery. The experiments...
Biotechnology uses microorganisms and/or enzymes to obtain specific products through fermentative processes genetic engineering techniques. Examples of these are active ingredients, such as hyaluronic acid, kojic resveratrol, and some enzymes, which used in skin anti-aging products. In addition, certain growth factors, algae, stem cells, peptides have been included cosmetics aesthetic medicines. Thus, biotechnology, medicines now closely linked, the production high-quality more effective...
Abstract: Given its advantages in skin application (eg, hydration, antiaging, and protection), argan oil could be used both dermatological cosmetic formulations. Therefore, the preparation of nanostructured lipid carriers (NLCs) using as a liquid is promising technique, since former constitute well-established systems for dermal delivery. The aim this work was to develop topical formulation NLCs improve hydration. Firstly an NLC dispersion developed characterized, afterward NLC-based...
The nasal route has been investigated as a promising alternative for drug delivery to the central nervous system, avoiding passage through blood-brain barrier and improving bioavailability. In this sense, it is necessary develop test effectiveness of new formulations proposed management neurological disorders. Thereby, aim work was characterize an ion sensitive in situ hydrogel containing diazepam-loaded nanostructured lipid carriers (DZP-NLC) treatment epilepsy. Physical characterization...