A5055612869- Air Quality and Health Impacts
- Climate Change and Health Impacts
- COVID-19 impact on air quality
- Vehicle emissions and performance
- Air Quality Monitoring and Forecasting
- Pneumonia and Respiratory Infections
- Health, Environment, Cognitive Aging
- Nutritional Studies and Diet
- Water Treatment and Disinfection
- Cardiovascular Health and Risk Factors
- Pleural and Pulmonary Diseases
- Inhalation and Respiratory Drug Delivery
- Traffic and Road Safety
- Bacterial Infections and Vaccines
- Stress Responses and Cortisol
- Vitamin C and Antioxidants Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Energy and Environment Impacts
- Indoor Air Quality and Microbial Exposure
- Streptococcal Infections and Treatments
MRC Toxicology Unit
2019-2023
University of Cambridge
2019-2022
University of Leicester
2020
Imperial College London
2017-2018
In December 2019, a novel disease, coronavirus disease 19 (COVID-19), emerged in Wuhan, People's Republic of China. COVID-19 is caused by (SARS-CoV-2) presumed to have jumped species from another mammal humans. This virus has rapidly spreading global pandemic. To date, over 300,000 cases been reported England and 40,000 patients died. While progress achieved managing this the factors addition age that affect severity mortality not clearly identified. Recent studies several countries...
ABSTRACT In December 2019, a novel disease, coronavirus disease 19 (COVID-19), emerged in Wuhan, People’s Republic of China. COVID-19 is caused by (SARS-CoV-2) presumed to have jumped species from another mammal humans. This virus has rapidly spreading global pandemic. To date, thousands cases been reported England, and over 25,000 patients died. While progress achieved managing this the factors addition age that affect severity mortality not clearly identified. Recent studies several...
Abstract Studies have emphasised the importance of combustion-derived particles in eliciting adverse health effects, especially those produced by diesel vehicles. In contrast, few investigations explored potential toxicity derived from tyre and brake wear, despite their significant contributions to total roadside particulate mass. The objective this study was compare relative compositionally distinct abrasion dust (BAD) exhaust (DEP) a cellular model that is relevant human airways. Although...
Exposure to particulate matter (PM), a major component of air pollution, is associated with exacerbation chronic respiratory disease, and infectious diseases such as community-acquired pneumonia. Although PM can cause adverse health effects through direct damage host cells, our previous study showed that also impact bacterial behaviour by promoting in vivo colonization. In this we describe the genetic mechanisms involved response exposure black carbon (BC), constituent found most sources...
Inflammation, oxidative stress and reduced cardiopulmonary function following exposure to ultrafine particles (UFP) from airports has been reported but the biological pathways underlying these toxicological endpoints remain be explored. Urinary metabolomics offers a robust method by which changes in cellular pathway activity can characterised environmental exposures.We assessed impact of short-term exposures UFP different sources at major airport on human urinary metabolome.21 healthy,...
The environment can elicit biological responses such as oxidative stress (OS) and inflammation a consequence of chemical, physical, or psychological changes. As population studies are essential for establishing these environment-organism interactions, biomarkers OS critical in formulating mechanistic hypotheses. By using examples induced by various mechanisms, we focus on the that have been used to assess conditions. We discuss difference between result chemical reaction (such lipid...
Air pollution is a major global health problem, with around 91% of the world’s population living in areas that exceed WHO air guidelines. This complex mix pollutants almost always includes particulate matter (PM), and this has greatest impact on human health. PM exposure contributes to range diseases such as COPD, heart disease respiratory infections. Our recent publication was first document well damaging host, direct bacteria can cause We showed Black Carbon (BC) results species-specific...
Abstract Tyre wear is an increasing source of ambient particulate matter pollution in the UK and around world. Currently, tyre accounts for 11% total (PM2.5) UK, over next 10 years that figure projected to steadily increase, with brake emissions reach 6 kilotonnes by 2030. Being able reliably identify monitor PM sources importance due its potential human health effects. Here we present a series characterisation experiments on particles, size-fractionated using dynamometer. Chemical elemental...
Abstract Exposure to brake abrasion dust (BAD) reduces the phagocytic capacity of macrophages, possibly contributing increased risk airway infections in polluted regions. The mechanisms that underlie this toxicity remain be characterised and, considering pre-exposure respiratory bacteria alternative traffic-related particulates enhances their dissemination into lungs mice, may include changes virulence pathogens themselves. Dual proteomic screening (TMT-labelled UPLC-MS) was performed for...
Air pollution is the single largest environmental health risk worldwide. Particulate matter (PM) air released as a result of fossil fuel combustion and vehicle motion, breaking tyre wear. It has been shown that exposure to PM can cause increased levels respiratory disease, including exacerbation COPD, which frequently associated with bacterial infection. Despite this, effects on COPD bacteria, includingHaemophilus influenzae, Moraxella catarrhalis Streptococcus pneumoniae are largely...