A5081097908- Psychosomatic Disorders and Their Treatments
- Amyotrophic Lateral Sclerosis Research
- Mental Health and Psychiatry
- Neurogenetic and Muscular Disorders Research
- Biomedical Ethics and Regulation
- Functional Brain Connectivity Studies
- Obsessive-Compulsive Spectrum Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bipolar Disorder and Treatment
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Electroconvulsive Therapy Studies
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- Multiple Sclerosis Research Studies
- Neurosurgical Procedures and Complications
- Polyomavirus and related diseases
- Action Observation and Synchronization
- Transcranial Magnetic Stimulation Studies
- Epilepsy research and treatment
- Schizophrenia research and treatment
- Autoimmune Neurological Disorders and Treatments
- Neurology and Historical Studies
University College London
2011-2025
The Royal Free Hospital
2015-2025
King's College Hospital NHS Foundation Trust
2019-2024
King's College London
2006-2024
South London and Maudsley NHS Foundation Trust
2019-2024
King's College Hospital
2020-2024
National Health Service
2024
Kent and Medway Medical School
2024
Kent and Medway NHS and Social Care Partnership Trust
2024
Medway School of Pharmacy
2024
The assumption that patients with bipolar disorder make a full inter-episode recovery has been challenged by limited evidence suggests neuropsychological dysfunction in may persist beyond episodes of illness.To test the hypothesis euthymic show impairment.A battery tests (assessed attention, working memory, learning and executive function) was administered to three matched groups subjects: good-outcome (n = 21); poor-outcome 20); controls 20). All were clinically euthymic, although some had...
No study has simultaneously explored key components of Beck's model cognitive vulnerability to depression in people with bipolar disorders.We compared 41 euthymic patients 20 healthy control subjects. All subjects were assessed on the Hamilton Rating Scale for Depression, Autobiographical Memory Test and Mean Ends Problem-Solving procedure also completed Beck Depression Inventory, Dysfunctional Attitude Scale, Sociotropy Autonomy Rosenberg Self-Esteem Questionnaire.In comparison subjects,...
Fatigue is common in multiple sclerosis (MS) and an important cause of disability. However, the fatigue poorly understood. This study aimed to describe frequency pattern sleep disturbance a group outpatients with MS, investigate relationship between fatigue. Sixty MS completed Severity Scale (FSS) Epworth Sleepiness kept diary for seven days. excessive daytime sleepiness were this patients (64 32%). Sleep problems on at least two nights per week occurred frequently, including initial...
Replicable risk factors for ALS include increasing age, family history and being male. The male: female ratio has been reported as between 1 3. We tested the hypothesis that sex changes with age in a population register covering south-east of England. before after 51 years was compared using Z-test proportions. Kendall's tau used to assess relationship group incidence prevalence data. Publicly available data from Italian Irish registers were results. There significant difference proportion...
Altered interoception may be a pathophysiological mechanism in functional neurological disorder (FND). However, findings have been inconsistent across interoceptive dimensions FND including motor symptoms (FMS) and seizures (FS). Here, individuals with FMS/FS (n = 17) healthy controls (HC, n completed measures of accuracy insight (adapted heartbeat tracking task [HTT] confidence ratings), time estimation control (TET) the Multidimensional Assessment Interoceptive Awareness-2 (MAIA-2) to...
<i>Background/Aims:</i> We aimed to estimate the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in South East England. The reported ALS varies between 0.44 3.2 per 100,000 person years. This can partly be explained by differences design diagnostic criteria used. There is little population data concerning England, particularly East. <i>Methods:</i> A study South-East England (total population: 2,890,482) was carried out multiple sources including our...
In this study, we investigated whether diffusion tensor MRI (DTI) could detect progressive corticospinal tract degeneration in amyotrophic lateral sclerosis (ALS) and changes variables reflected clinical deterioration. Twenty‐three ALS patients 25 healthy volunteers underwent whole brain DTI. Patients a subset (n = 12) of controls returned for second scan. Clinical measures disease severity were assessed the group. Changes fractional anisotropy (FA) mean diffusivity (MD) measured along using...
<h3>Background</h3> The homogeneous genotype and stereotyped phenotype of a unique familial form amyotrophic lateral sclerosis (ALS) (patients homozygous for aspartate-to-alanine mutations in codon 90 (homD90A) superoxide dismutase 1) provides an ideal model studying genotype/phenotype interactions pathological features compared with heterogeneous apparently sporadic ALS. authors aimed to use diffusion tensor tractography quantify compare changes the intracerebral corticospinal tracts...
This study aimed to provide a preliminary assessment of objective and subjective neurocognitive functioning in individuals with functional motor symptoms (FMS) and/or seizures (FS). We tested the hypotheses that FMS/FS group would display poorer attentional executive functioning, altered social cognition, reduced metacognitive accuracy.
The basis of heterogeneity in the clinical presentation and rate progression amyotrophic lateral sclerosis (ALS) is poorly understood.To use diffusion tensor imaging as a measure axonal pathologic features vivo ALS to compare homogeneous form familial (homozygous D90A SOD1 [superoxide dismutase 1]) with sporadic ALS.Cross-sectional study.Tertiary referral neurology clinic.Twenty patients ALS, 6 homozygous 21 healthy control subjects.Fractional anisotropy cerebral white matter.Patients showed...
This study examined etiological factors and symptom triggers of functional motor symptoms (FMS) or seizures (FS) assessed potential relationships with relevant clinical features (i.e., symptoms, quality life, general functioning).
![Graphic][1]</img> "This is an exciting era for young neurologists" ABN Fellow Thomas Coysh talks to Biba Stanton on research in neurology training ![Graphic][2]</img> Dr. Tom Coysh, a clinical fellow at UCL Institute of Prion Diseases and the National Clinic, supported by Association British Neurologists (ABN) Fellowship Scheme, about his value undertaking fellowship as part training. Q: Could you tell us your area research? A: My prion diseases, which although rare, are universally fatal...
<i>Background:</i> Amyotrophic lateral sclerosis (ALS) is a degenerative disease of motor neurons that causes progressive paralysis and eventually results in death from respiratory failure. Environmental factors trigger ALS might result pattern geographical clustering cases. We tested this hypothesis using the South-East England population register, which covers south-east London, Kent parts neighbouring counties. <i>Methods:</i> The register’s catchment area was...
A 22-year-old African woman developed acute behavioural change, against a background of sickle cell disease with strokes requiring ventriculoperitoneal shunt. She alternated between mutism prolonged staring and posturing, state agitation elation echolalia. Cerebrospinal fluid (CSF) protein was elevated electroencephalogram showed mild slowing bitemporal slow sharp waves. We suspected catatonia secondary to possible autoimmune encephalitis but her condition persisted despite intravenous...