A5057470790- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Animal Behavior and Welfare Studies
- SARS-CoV-2 and COVID-19 Research
- Geriatric Care and Nursing Homes
- Poxvirus research and outbreaks
- Health disparities and outcomes
- Food Allergy and Anaphylaxis Research
- Mycobacterium research and diagnosis
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Zoonotic diseases and public health
- Global Health Care Issues
- SARS-CoV-2 detection and testing
- Bacillus and Francisella bacterial research
- Tuberculosis Research and Epidemiology
- Salmonella and Campylobacter epidemiology
- Listeria monocytogenes in Food Safety
- Agricultural safety and regulations
- Data-Driven Disease Surveillance
- Viral Infections and Outbreaks Research
- Health Systems, Economic Evaluations, Quality of Life
- Amyotrophic Lateral Sclerosis Research
- Foreign Body Medical Cases
- COVID-19 Pandemic Impacts
UK Health Security Agency
2022-2023
Public Health England
2022
University of Liverpool
2015-2021
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2021
Farr Institute
2015-2018
Royal Veterinary College
2013-2016
Swedish Veterinary Agency
2014
International Livestock Research Institute
2014
University of York
2013
King's College London
2007
<i>Background/Aims:</i> We aimed to estimate the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in South East England. The reported ALS varies between 0.44 3.2 per 100,000 person years. This can partly be explained by differences design diagnostic criteria used. There is little population data concerning England, particularly East. <i>Methods:</i> A study South-East England (total population: 2,890,482) was carried out multiple sources including our...
There are concerns that sotrovimab has reduced efficacy at reducing hospitalisation risk against the BA.2 sub-lineage of Omicron SARS-CoV-2 variant. We performed a retrospective cohort (n = 8850) study individuals treated with in community, objective assessing whether there were any differences cases compared BA.1. estimated hazard ratio hospital admission length stay 2 days or more was 1.17 for BA.1 (95%CI 0.74-1.86). These results suggest similar between two sub-lineages.
Abstract Objectives Sotrovimab is one of several therapeutic agents that have been licensed to treat people at risk severe outcomes following COVID-19 infection. However, there are concerns it has reduced efficacy with the BA.2 sub-lineage Omicron (B.1.1.529) SARS-CoV-2 variant. We compared individuals BA.1 or variant treated in community assess their hospital admission. Methods performed a retrospective cohort study and either had classification. Results Using Stratified Cox regression...
Trade in live animals can contribute to the introduction of exotic diseases, maintenance and spread endemic diseases. Annually millions are moved across Europe for purposes breeding, fattening slaughter. Data on number were obtained from Directorate General Sanco (DG Sanco) 2011. These converted livestock units enable direct comparison species their movements mapped, used calculate indegrees outdegrees 27 European countries density transitivity within Europe. This provided opportunity...
When SARS-CoV-2 Omicron emerged in 2021, S gene target failure enabled differentiation between and the dominant Delta variant. In England, where surveillance (SGTS) was already established, this led to rapid identification (within ca 3 days of sample collection) possible cases, alongside real-time modelling growth. SGTS key public health action (including case incident management), we share applied insights on how when use SGTS.
Abstract Background Like many other countries worldwide, the UK experienced a national outbreak of monkeypox disease in May 2022, with case numbers rising rapidly, mainly among gay, bisexual and men who have sex (GBMSM). To control outbreak, Modified Vaccinia Ankara–Bavaria Nordic (MVA-BN), an attenuated smallpox vaccine, was offered to high-risk GBMSM. We assessed effectiveness single MVA-BN dose against Methods Monkeypox cases England were sent questionnaires collecting information on...
With over 800 million cases globally, campylobacteriosis is a major cause of food borne disease. In temperate climates incidence highly seasonal but the underlying mechanisms are poorly understood, making human disease control difficult. We hypothesised that observed patterns reflect complex interactions between weather, risk behaviour, immune status and level contamination. Only by understanding these can we find effective interventions. analysed trends in Campylobacter NE England from 2004...
SUMMARY Tuberculosis (TB) in livestock, caused by Mycobacterium bovis , persists many countries. In the UK and Ireland, efforts to control TB through culling of badgers ( Meles meles ), principal wildlife host, have failed there is significant interest vaccination as an alternative or complementary strategy. Using a simulation model, we show that where self-contained within badger population are no external sources infection, limited-duration at high level efficacy can reduce even eradicate...
A retrospective study was carried out to provide updated knowledge of the spatial pattern Angiostrongylus vasorum infection in Southern England and investigate associations between selected host characteristics (age, breed, sex), risk clinical presentation (cardiorespiratory signs v haemorrhagic diathesis). One hundred forty-one cases diagnosed April 1999 July 2012 were compared with a control population dogs referred same hospital. significant association found diathesis breed but not for...
The COVID-19 pandemic has had high mortality rates in the elderly and frail worldwide, particularly care homes. This is driven by difficulty of isolating homes from wider community, large population sizes within facilities (relative to typical households), age/frailty residents. To quantify risk posed disease, case fatality (CFR) an important tool. quantifies proportion cases that result death. Throughout pandemic, CFR amongst home residents England been monitored closely. estimate CFR, we...
Advances in Large Language Models (LLMs) have led to significant interest their potential support human experts across a range of domains, including public health. In this work we present automated evaluations LLMs for health tasks involving the classification and extraction free text. We combine six externally annotated datasets with seven new internally evaluate processing text related to: burden, epidemiological risk factors, interventions. initially five open-weight (7-70 billion...
Abstract Norovirus (NoV) is the greatest cause of infectious intestinal disease in UK. The burden associated with foodborne outbreaks underestimated part because data are dispersed across different organisations. Each looks at through a lens. To estimate NoV from seafood including shellfish we used capture-recapture technique using datasets three organisations currently involved collecting information on outbreaks. number related to England was estimated for period 2004–2011. combined...
Background Bovine viral diarrhoea (BVD) is a production disease commonly found in British cattle herds. Species other than have been shown to be infected with the virus, thereby providing potential source of infection for livestock. This study surveyed serum samples taken from 596 culled wild deer England and Wales, between 2009 2010, presence BVD antibodies. Methods were tested SVANOVIR BVDV p80‐Ab ELISA subset 64 IDEXX ELISA. results confirmed using neutralisation tests. Results 2/596...
Abstract Background The UK Health Security Agency (UKHSA) COVID-19 Outbreak Surveillance Team (OST) was established in June 2020 to provide Local Authorities (LAs) England with surveillance intelligence aid their response the SARS-CoV-2 epidemic. Reports were produced using standardised metrics an automated format. Here we evaluate how reports influenced decision making, resources evolved and they could be refined meet requirements of stakeholders future. Methods Public health professionals...
The COVID-19 pandemic has had high mortality rates in the elderly and frail worldwide, particularly care homes. This is driven by difficulty of isolating homes from wider community, large population sizes within facilities (relative to typical households), age/frailty residents. To quantify risk posed disease, case fatality (CFR) an important tool. quantifies proportion cases that result death. Throughout pandemic, CFR amongst home residents England been monitored closely. estimate CFR, we...