A5091885974- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- Emergency and Acute Care Studies
- Bacillus and Francisella bacterial research
- Poxvirus research and outbreaks
- Child and Adolescent Health
- Infective Endocarditis Diagnosis and Management
- SARS-CoV-2 detection and testing
- Herpesvirus Infections and Treatments
- Influenza Virus Research Studies
- Long-Term Effects of COVID-19
- Zoonotic diseases and public health
- Viral Infections and Outbreaks Research
- COVID-19 Impact on Reproduction
- Child and Adolescent Psychosocial and Emotional Development
- COVID-19 and healthcare impacts
- Adolescent and Pediatric Healthcare
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Childhood Cancer Survivors' Quality of Life
- Multiple Sclerosis Research Studies
UK Health Security Agency
2021-2024
London School of Hygiene & Tropical Medicine
2022
St George's, University of London
2022
Public Health England
2021
During July-December 2021, after COVID-19 restrictions were removed in England, invasive pneumococcal disease incidence children <15 years of age was higher (1.96/100,000 children) than during the same period 2020 (0.7/100,000 and prepandemic 2017-2019 (1.43/100,000 children). Childhood vaccine coverage should be maintained to protect population.
BackgroundThe UK transition from a 2 + 1 to infant immunisation schedule with the 13-valent pneumococcal conjugate vaccine (PCV13) on Jan 1, 2020, coincided start of COVID-19 pandemic. We describe epidemiology invasive disease (IPD) in England over 6 financial years (April March 31) between 2017–18 and 2022–23.MethodsWe used prospective national surveillance data, including serotyping whole-genome sequencing isolates, analyse IPD trends by age year. compared breakthrough infections failure...
Paediatric pneumococcal conjugate vaccine (PCV) programmes in England using seven-valent PCV (PCV7) 2006 and 13-valent (PCV13) 2010 have reduced vaccine-type invasive disease, but the overall effect has been by an increase disease due to non-vaccine serotypes serotype 3. We developed transmission models investigate potential on of higher valency PCVs covering additional two (ie, 15-valent [PCV15]) or seven 20-valent [PCV20]) England.
In 2020, COVID-19 pandemic restrictions led to a major suppression of meningococcal disease in England. Here we describe the epidemiology invasive three years prior pandemic, and immediately after introduction restrictions.
Coronavirus Disease 2019 (COVID-19) deaths are rare in children and young people (CYP). The high rates of asymptomatic mild infections complicate assessment cause death CYP. We assessed the all CYP with a positive Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) test since start pandemic England.CYP aged <20 years who died within 100 days laboratory-confirmed SARS-CoV-2 infection between 01 March 2020 31 December 2021 England were followed up detail, using national databases, surveillance...
Abstract Background Most individuals with COVID-19 will recover without sequelae, but some develop long- term multi-system impairments. The definition, duration, prevalence and symptoms associated long COVID, however, have not been established. Methods Public Health England (PHE) initiated longitudinal surveillance of clinical non-clinical healthcare workers for monthly blood sampling SARS-CoV-2 antibodies in March 2020. Eight months after enrolment, participants completed an online...
BackgroundInvasive Haemophilus influenzae serotype a (Hia) disease is rare, with most cases reported among Indigenous populations in North America. In England, national surveillance was enhanced following an increase laboratory-confirmed invasive Hia since the 2016–17 epidemiological year. This study aimed to describe trends, clinical characteristics of cases, and assess potential genomic drivers.MethodsHospital laboratories England routinely submit H isolates UK Health Security Agency for...
Abstract England, like other countries that experienced a large outbreak of emergent mpox in 2022, continued to record cases during 2023 at low but steady frequency. Comprehensive national surveillance shows continue occur primarily among gay, bisexual and men who have sex with mostly London. Of 137 2023, around half were acquired overseas, vaccinated, one case reinfection was reported. Eleven people required hospital care. High vaccination uptake, has provided good coverage those higher...
Determination of serotypes
Pneumococcal carriage in children has been extensively studied, but healthy adults and its relationship to invasive pneumococcal disease (IPD) is less understood.
Reported mpox cases in England continued at a low but steady frequency during 2023. Of 137 reported 2023, approximately half were acquired overseas and vaccinated persons. Estimated effectiveness of 2-dose vaccine was 80%, no patient hospitalized.
On Jan 1, 2020, the UK transitioned from a 2+1 to 1+1 national infant immunisation schedule with 13-valent pneumococcal conjugate vaccine (PCV13). We assessed whether PCV13 had any impact on incidence, disease characteristics, or outcomes after invasive (IPD) in eligible children aged 0-3 years.
Abstract Background Like many other countries worldwide, the UK experienced a national outbreak of monkeypox disease in May 2022, with case numbers rising rapidly, mainly among gay, bisexual and men who have sex (GBMSM). To control outbreak, Modified Vaccinia Ankara–Bavaria Nordic (MVA-BN), an attenuated smallpox vaccine, was offered to high-risk GBMSM. We assessed effectiveness single MVA-BN dose against Methods Monkeypox cases England were sent questionnaires collecting information on...
Haemophilus influenzae serotype b (Hib) conjugate vaccines have been highly successful in reducing the Hib disease worldwide. Recently, several European countries reported an increase invasive disease. We aimed to describe epidemiology, clinical characteristics, genomic trends, and outcomes of over past 11 years England.
Objective To assess implementation and ease of control measures in schools as reported by staff parents. Design A descriptive cross-sectional survey. Setting Staff parents/guardians the 132 primary 19 secondary participating COVID-19 surveillance school kids (sKIDs sKIDsPLUS Studies). Main outcome measure Prevalence implemented autumn 2020, parental perception implementation. Results In total, 56 151 (37%) participated this study, with 1953 parents 986 members completing questionnaire. Most...
Following the removal of COVID-19 restrictions in England, IPD incidence children aged <15 years was higher during July-December 2021 (1.96/100,000; 95%CI,1.70-2.25), compared to same period 2020 (0.7, 0.54-1.88) and three pre-pandemic years, 2017-19 (1.43/100,000 (1.21-1.68). Adult also increased but remained 48% below period.
Background: COVID-19 deaths are rare in children and young people (CYP). The high rates of asymptomatic mild infections complicate assessment cause death CYP. We assessed the all CYP with a positive SARS-CoV-2 test since start pandemic England.Methods: aged <20 years who died within 100 days laboratory-confirmed infection between 01 March 2020 31 December 2021 England were followed-up detail, using national databases, surveillance questionnaires, post-mortem reports clinician...
In England, the emergence more transmissible SARS-CoV-2 variant Alpha (B.1.1.7) led to a third national lockdown from December 2020, including restricted attendance at schools. Nurseries, however, remained fully open. COVID-19 outbreaks (≥ 2 laboratory-confirmed cases within 14 days) in nurseries were investigated assess risk of infection and cumulative incidence staff children over three-month period when community infections rates high was spreading rapidly across England.This...
Abstract Objective The main objective was to assess implementation of and ease control measures in schools as reported by staff parents. Design Cross-sectional study. Setting Staff parents/guardian participants the 132 primary 20 secondary participating sKIDs sKIDsPLUS surveillances. Main outcome measure Prevalence implemented Autumn 2020, parental perception acceptability conducting school surveillance studies. Results In total, 56/152 (37%) Public Health England’s study COVID accepted...
In a national cohort of 12,788 adolescents, those reporting parents experiencing ongoing problems from COVID-19 had 1.79-fold (95%CI: 1.58-2.02) higher odds LONG COVID 6 months after SARS-CoV-2 PCR-test than without symptoms, independent age, sex, deprivation and infection status.