A5047481687- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Virology and Viral Diseases
- Influenza Virus Research Studies
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Complement system in diseases
- SARS-CoV-2 and COVID-19 Research
- Neonatal and Maternal Infections
- Infective Endocarditis Diagnosis and Management
- Escherichia coli research studies
- Sinusitis and nasal conditions
- vaccines and immunoinformatics approaches
- Bacillus and Francisella bacterial research
- Immunotherapy and Immune Responses
- Antibiotic Resistance in Bacteria
- RNA and protein synthesis mechanisms
- Hemoglobinopathies and Related Disorders
- Congenital Ear and Nasal Anomalies
- Reproductive tract infections research
- Travel-related health issues
- Atomic and Subatomic Physics Research
- Monoclonal and Polyclonal Antibodies Research
- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
Manchester Royal Infirmary
2014-2023
National Health Service
2022-2023
UK Health Security Agency
2021-2023
Public Health England
2013-2021
National Public Health Laboratory
2012
Public Health Laboratory
2012
Weatherford College
2011
In September 2015, the United Kingdom introduced multicomponent meningococcal group B vaccine (4CMenB, Bexsero) into its publicly funded national immunization program at a reduced two-dose priming schedule for infants, with 12-month booster.
Introduction. In England, antenatal pertussis immunization using a tetanus/low-dose diphtheria/5-component acellular-pertussis/inactivated-polio (TdaP5/IPV) vaccine was introduced in October 2012. We assessed infant responses to antigens the maternal and those conjugated tetanus (TT) or diphtheria toxin variant, CRM.
In December 2013, a multicomponent meningococcal serogroup B (4CMenB) vaccine was used before licensure on the basis of special consideration by Food and Drug Administration to respond an outbreak Neisseria meningitidis at U.S. university. Data suggested that vaccination would control because isolates expressed antigens were closely related (factor H–binding protein [fHbp] neisserial heparin-binding antigen). We quantified immune responses induced 4CMenB during outbreak.
In 2020, COVID-19 pandemic restrictions led to a major suppression of meningococcal disease in England. Here we describe the epidemiology invasive three years prior pandemic, and immediately after introduction restrictions.
Invasive meningococcal disease (IMD), caused by Neisseria meningitidis , can have a fatality rate as high 10%, even with appropriate treatment. In the UK, penicillin is administered to patients in primary care whilst third generation cephalosporins, cefotaxime and ceftriaxone, are secondary care. The first-choice antibiotic for chemoprophylaxis of close contacts ciprofloxacin, followed rifampicin. Immunocompromised individuals often recommended vaccination due greater risk IMD. Resistance...
Neisseria meningitis remains a leading cause of sepsis and meningitis, vaccines are required to prevent infections by this important human pathogen. Factor H binding protein (fHbp) is key antigen that elicits protective immunity against the meningococcus recruits host complement regulator, fH. As high affinity interaction between fHbp fH could impair immune responses, we sought identify non-functional fHbps act as effective immunogens. This was achieved alanine substitution from all three...
To describe patients with inherited and acquired complement deficiency who developed invasive meningococcal disease (IMD) in England over the last decade.
University students have high rates of pharyngeal carriage Neisseria meningitidis. Interruption acquisition is an important mechanism vaccines for inducing herd protection. 4CMenB and MenACWY-CRM been shown to be immunogenic against meningococcal serogroups B ACWY respectively in younger age groups, also elicit a modest impact on vaccinated students. However, vaccine responses university the serum bactericidal antibody (SBA) titers are undetermined. Immunogenicity two doses or one dose was...
ABSTRACT Asymptomatic and persistent colonization of the upper respiratory tract by Neisseria meningitidis occurs despite elicitation adaptive immune responses against surface antigens. A putative mechanism for facilitating host persistence this bacterial commensal pathogen is alterations in expression antigens simple sequence repeat (SSR)-mediated phase variation. We investigated how often variation during carriage analyzing SSRs eight loci multiple isolates from 21 carriers representative...
Information on transmission of meningococcal infection in the African meningitis belt is scarce. We aimed to describe patterns Neisseria meningitidis (meningococcus) households belt.Cross-sectional carriage surveys were done seven countries (Chad, Ethiopia, Ghana, Mali, Niger, Nigeria, and Senegal) between Aug 1, 2010, Oct 15, 2012. Meningococcal carriers identified these all available people their recruited into this longitudinal cohort study. took pharyngeal swabs at first visit further...
A physicochemical and immunological study of the stability three different meningococcal (Men) ACWY conjugate vaccines was performed to evaluate any patterns serogroup oligo- or polysaccharide-specific carrier protein-specific that would affect immunogenicity. Critical quality stability-indicating characteristics were measured, with supporting suitability both HPLC-SEC HPAEC-PAD methods detect changes following inappropriate vaccine storage. All final products, ACWY-CRM197, -DT -TT had...
In July 2021 COVID-19 containment measures were withdrawn in England. Between September and November 2021, IMD cases increased with group B disease adolescents/young adults rising sharply exceeding pre-pandemic levels. The serogroup age distribution of these suggests that meningococcal vaccination programmes are maintaining low rates C/W/Y however immunity against strains high transmission meningococci among resulted the return disease, particularly university students.
Protection after meningococcal C (MenC) conjugate (MCC) vaccination in early childhood is short-lived. Boosting with a quadrivalent vaccine teenage years, high-risk period for MenC disease, should protect against additional serogroups but might compromise response. The carrier protein the primary MCC determines response to booster toddlers, relationship between and given later unclear. This study compared responses CRM-conjugated or tetanus toxoid (TT)-conjugated MenACWY teenagers primed...
Two haemoglobin-binding proteins, HmbR and HpuAB, contribute to iron acquisition by Neisseria meningitidis. These receptors are subject high frequency, reversible switches in gene expression - phase variation (PV) due mutations homopolymeric (poly-G) repeats present the open reading frame. The distribution PV state of these was assessed for a representative collection isolates from invasive meningococcal disease patients England, Wales Northern Ireland. Most major clonal complexes had only...