Laura Coughlan

ORCID: 0000-0002-0300-4950
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About
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Research Areas
  • COVID-19 epidemiological studies
  • COVID-19 and Mental Health
  • COVID-19 Clinical Research Studies
  • Liver Disease Diagnosis and Treatment
  • Viral gastroenteritis research and epidemiology
  • Health disparities and outcomes
  • SARS-CoV-2 and COVID-19 Research
  • Parvovirus B19 Infection Studies
  • Virus-based gene therapy research
  • Viral Infections and Outbreaks Research
  • COVID-19 Impact on Reproduction
  • Data-Driven Disease Surveillance
  • Respiratory viral infections research
  • Chronic Disease Management Strategies
  • Primary Care and Health Outcomes
  • Influenza Virus Research Studies
  • SARS-CoV-2 detection and testing
  • Long-Term Effects of COVID-19
  • Climate Change and Health Impacts
  • Hepatitis C virus research
  • Global Public Health Policies and Epidemiology
  • COVID-19 and healthcare impacts
  • HIV, Drug Use, Sexual Risk
  • Food Security and Health in Diverse Populations
  • Clinical Nutrition and Gastroenterology

UK Health Security Agency
2022-2024

Public Health England
2020-2022

London School of Hygiene & Tropical Medicine
2022

Government of the United Kingdom
2020

BackgroundHouseholds appear to be the highest risk setting for COVID-19 transmission. Large household transmission studies in early stages of pandemic Asia reported secondary attack rates ranging from 5 30%.AimWe aimed investigate dynamics and community settings UK.MethodsA prospective case-ascertained study design based on World Health Organization FFX protocol was undertaken UK following detection first case late January 2020. Household contacts cases were followed using enhanced...

10.2807/1560-7917.es.2022.27.15.2001551 article EN cc-by Eurosurveillance 2022-04-14

England has experienced one of the highest excess in all-cause mortality Europe during current COVID-19 pandemic. As emerged, rapidly increased, starting March 2020. The observed pandemic was higher than excesses noted past 5 years. It concerned all regions and age groups, except 0–14 year olds, but more pronounced London region those aged ≥ 85

10.2807/1560-7917.es.2020.25.28.2001239 article EN cc-by Eurosurveillance 2020-07-16

Abstract Background Households appear to be the highest risk setting for transmission of COVID-19. Large household studies were reported in early stages pandemic Asia with secondary attack rates ranging from 5–30% but few large scale have been conducted outside Asia. Methods A prospective case ascertained study design based on World Health Organization FFX protocol was undertaken UK following detection first late January 2020. Household contacts cases followed using enhanced surveillance...

10.1101/2020.08.19.20177188 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2020-08-22

An increase in acute severe hepatitis of unknown aetiology previously healthy children the UK March, 2022, triggered global case-finding. We aimed to describe epidemiological investigations cases and their possible causes.We actively surveilled unexplained paediatric (transaminase >500 international units per litre) younger than 16 years presenting since Jan 1, through notifications from paediatricians, microbiologists, liver units; we collected demographic, clinical, exposure information....

10.1016/s2352-4642(23)00215-8 article EN cc-by The Lancet Child & Adolescent Health 2023-09-26

Objectives: Following detection of the first virologically-confirmed cases COVID-19 in Great Britain, an enhanced surveillance study was initiated by Public Health England to describe clinical presentation, course disease and identify risk factors for infection few hundred cases. Methods: Information collected on according First Few X WHO protocol. Case-control analyses sensitivity, specificity predictive value symptoms were conducted. Point prevalences underlying health conditions among UK...

10.1101/2020.05.18.20086157 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2020-05-22

Background A multi-tiered surveillance system based on influenza was adopted in the United Kingdom early stages of coronavirus disease (COVID-19) epidemic to monitor different disease. Mandatory social and physical distancing measures (SPDM) were introduced 23 March 2020 attempt limit transmission. Aim To describe impact SPDM COVID-19 activity as detected through systems. Methods Data from national population surveys, web-based indicators, syndromic surveillance, sentinel swabbing,...

10.2807/1560-7917.es.2021.26.11.2001062 article EN cc-by Eurosurveillance 2021-03-18

In England, the emergence more transmissible SARS-CoV-2 variant Alpha (B.1.1.7) led to a third national lockdown from December 2020, including restricted attendance at schools. Nurseries, however, remained fully open. COVID-19 outbreaks (≥ 2 laboratory-confirmed cases within 14 days) in nurseries were investigated assess risk of infection and cumulative incidence staff children over three-month period when community infections rates high was spreading rapidly across England.This...

10.1186/s12889-022-14228-z article EN cc-by BMC Public Health 2022-10-01

Background: The reopening of schools during the COVID-19 pandemic has raised concern for safety staff and students, their families wider community. We monitored SARS-CoV-2 infection rates in school-aged children compared them with adult before after reopened England. Methods: Public Health England receives daily electronic reports all tests nationally. by school year from July to November 2020 were analysed, including effect a week-long half-term break October national month-long lockdown...

10.2139/ssrn.3761920 article EN SSRN Electronic Journal 2020-01-01

Background: Mandatory social and physical distancing measures (SPDM) were introduced in the UK on 23rd March 2020. A multi-tiered surveillance system based influenza surveillance, was adopted from early stages of COVID-19 Epidemic to monitor different disease. We describe how impact SPDM detected through each these systems may be applied detect increases activity as are eased.Methods: Data national population surveys, web-based indicators, syndromic sentinel swabbing, respiratory outbreaks,...

10.2139/ssrn.3608109 article EN SSRN Electronic Journal 2020-01-01

Abstract Background In England, the emergence more transmissible SARS-CoV-2 variant Alpha (B.1.1.7) led to a third national lockdown from December 2020, including restricted attendance at schools. Nurseries, however, remained fully open. COVID-19 outbreaks (≥ 2 laboratory-confirmed cases within 14 days) in nurseries and assess risk of infection incidence rates staff children over three-month period when community infections were high was spreading rapidly across England. Methods This...

10.21203/rs.3.rs-1646307/v1 preprint EN cc-by Research Square (Research Square) 2022-06-14
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