Emma Davies
A5033059673- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Virus-based gene therapy research
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- Functional Brain Connectivity Studies
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Mental Health Research Topics
- Cytomegalovirus and herpesvirus research
- Advanced Neuroimaging Techniques and Applications
- Trauma and Emergency Care Studies
- COVID-19 and healthcare impacts
- Fungal and yeast genetics research
- Antifungal resistance and susceptibility
- Cardiac, Anesthesia and Surgical Outcomes
- Herpesvirus Infections and Treatments
- Cutaneous lymphoproliferative disorders research
- Pneumonia and Respiratory Infections
- Advanced MRI Techniques and Applications
- Lymphoma Diagnosis and Treatment
- Child Abuse and Trauma
- Fungal Biology and Applications
- Resilience and Mental Health
- Tuberculosis Research and Epidemiology
University of Cambridge
2021-2025
Wythenshawe Hospital
2024
Manchester University NHS Foundation Trust
2018-2023
Manchester Royal Infirmary
2016-2023
UK Health Security Agency
2022-2023
Royal Cornwall Hospital Trust
2023
Alternative Opportunities
2020-2022
University Hospital of Wales
2022
Cardiff University
2022
Public Health England
2020-2021
Nucleic acid amplification tests (NAATs) are the primary means of identifying acute infections caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2). Accurate and fast test results may permit more efficient use protective isolation resources allow rapid therapeutic interventions. We evaluated analytical clinical performance characteristics Xpert Xpress SARS-CoV-2 (Xpert) test, a rapid, automated molecular for SARS-CoV-2. Analytical sensitivity specificity/interference were...
Adolescent changes in human brain function are not entirely understood. Here, we used multiecho functional MRI (fMRI) to measure developmental change connectivity (FC) of resting-state oscillations between pairs 330 cortical regions and 16 subcortical 298 healthy adolescents scanned 520 times. Participants were aged 14 26 y on 1 3 occasions at least 6 mo apart. We found 2 distinct modes age-related FC: “conservative” “disruptive.” Conservative development was characteristic primary cortex,...
Abstract The frequency of antifungal resistance, particularly to the azole class ergosterol biosynthetic inhibitors, is a growing global health problem. Survival rates for those infected with resistant isolates are exceptionally low. Beyond modification drug target, our understanding molecular basis resistance in fungal pathogen Aspergillus fumigatus limited. We reasoned that clinically relevant could derive from transcriptional rewiring, promoting without concomitant reductions...
Genetic risk is thought to drive clinical variation on a spectrum of schizophrenia-like traits, but the underlying changes in brain structure that mechanistically link genomic schizotypal experience and behavior are unclear.
Abstract Neuroinvasive astrovirus ( VA 1‐ HMO ‐C) is an emerging life‐threatening infection in immunocompromised hosts. We describe 8‐month‐old child who died of 1/ ‐C encephalitis following bone marrow transplantation. The diagnosis was only made post‐mortem using RNA deep sequencing the brain. Repeat analysis brain tissue polymerase chain reaction specific primers for positive. Astrovirus should be included evaluation patients with similar encephalitis.
Model-free learning enables an agent to make better decisions based on prior experience while representing only minimal knowledge about environment’s structure. It is generally assumed that model-free state representations are outcome-relevant features of the environment. Here, we challenge this assumption by providing evidence a putative system assigns credit task irrelevant outcome. We examined data from 769 individuals performing well-described 2-step reward decision where stimulus...
Abstract Few studies assessing the effects of COVID-19 on mental health include prospective markers risk and resilience necessary to understand mitigate combined impacts pandemic, lockdowns, other societal responses. This population-based study young adults includes individuals from Neuroscience in Psychiatry Network ( n = 2403) recruited English primary care services schools 2012–2013 when aged 14–24. Participants were followed up three times thereafter, most recently during initial...
In 2009, the National Institute of Mental Health launched Research Domain Criteria, an attempt to move beyond diagnostic categories and ground psychiatry within neurobiological constructs that combine different levels measures (e.g., brain imaging behavior). Statistical methods can integrate such multimodal data, however, are often vulnerable overfitting, poor generalization, difficulties in interpreting results.We propose innovative machine learning framework combining multiple holdouts a...
Recent estimates of the global burden fungal disease suggest that their incidence has been drastically underestimated and mortality may rival malaria or tuberculosis. Azoles are principal class antifungal drug only available oral treatment for disease. occurrence increase in azole resistance is a major concern worldwide. Known mechanisms include over-expression efflux pumps mutation gene encoding target protein cyp51a, however, one most important pathogens humans, Aspergillus fumigatus, much...
This article describes the management of an outbreak multidrug-resistant Acinetobacter baumannii (MDR-Ab) at acute NHS Foundation Trust. The affected two respiratory wards and initial lasted 9 months, with first patient (index case) being identified in April 2015 final, tenth case, September 2015. was declared closed January 2016, but a further cases were July August 2016. Of 12 patients, eight colonised bacterium four infected. infections tract MDR-Ab, identical variable number tandem...
Abstract Understanding how variations in dimensions of psychometrics, IQ and demographics relate to changes brain connectivity during the critical developmental period adolescence early adulthood is a major challenge. This has particular relevance for mental health disorders where failure understand these links might hinder development better diagnostic approaches therapeutics. Here, we investigated this question 306 adolescents young adults (14–24 y, 25 clinically depressed) using...
An increase in acute severe hepatitis of unknown aetiology previously healthy children the UK March, 2022, triggered global case-finding. We aimed to describe epidemiological investigations cases and their possible causes.We actively surveilled unexplained paediatric (transaminase >500 international units per litre) younger than 16 years presenting since Jan 1, through notifications from paediatricians, microbiologists, liver units; we collected demographic, clinical, exposure information....
Adolescent development of human brain structural and functional networks is increasingly recognized as fundamental to emergence typical atypical adult cognitive emotional processes. We analysed multimodal magnetic resonance imaging (MRI) data collected from N <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" overflow="scroll"> <mml:mo>∼</mml:mo> </mml:math> 300 healthy adolescents (51%; female; 14 26 y) each scanned repeatedly in an accelerated longitudinal design,...
Abstract Introduction CONTACT is a national multidisciplinary study assessing the impact of COVID-19 pandemic upon diagnostic and treatment pathways among patients with pancreatic ductal adenocarcinoma (PDAC). Methods The consecutive newly diagnosed PDAC from pre-COVID-19 cohort (07/01/2019-03/03/2019) were compared to during first wave UK (‘ COVID’ cohort, 16/03/2020-10/05/2020) , 12-month follow-up. Results Among 984 (pre-COVID: n = 483, COVID: 501), COVID was less likely receive staging...
BackgroundMiddle East respiratory syndrome coronavirus (MERS-CoV) emerged in Saudi Arabia 2012 and caused an epidemic the Middle East. Public Health England (PHE) Manchester is one of two PHE centres UK that perform testing for MERS-CoV. The results MERS surveillance from to 2019 are presented this report.MethodsRetrospective data were collected returning travellers fitting case definition. Respiratory samples tested viruses MERS-CoV using in-house RT-PCR assay.ResultsFour hundred twenty-six...
Compulsive behavior is enacted under a belief that specific act controls the likelihood of an undesired future event. behaviors are widespread in general population despite having no causal relationship with events they aspire to influence. In current study, we tested whether there increased tendency assign value aspects task do not predict outcome (i.e., outcome-irrelevant learning) among individuals compulsive tendencies. We studied 514 healthy who completed self-report compulsivity,...