A5041136521- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Sex work and related issues
- Liver Disease Diagnosis and Treatment
- Opioid Use Disorder Treatment
- Global Health Care Issues
- Adolescent Sexual and Reproductive Health
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Streptococcal Infections and Treatments
- Health disparities and outcomes
- LGBTQ Health, Identity, and Policy
- Forensic Toxicology and Drug Analysis
- Healthcare Policy and Management
- Employment and Welfare Studies
- Viral gastroenteritis research and epidemiology
- Otolaryngology and Infectious Diseases
- Adolescent and Pediatric Healthcare
- Breast Cancer Treatment Studies
- Antimicrobial Resistance in Staphylococcus
- Pneumocystis jirovecii pneumonia detection and treatment
- Breast Lesions and Carcinomas
- Medication Adherence and Compliance
UK Health Security Agency
2022-2024
National Institute for Health Research
2022-2024
University College London
2014-2024
University of California, Irvine
2019-2023
Western University of Health Sciences
2023
The University of Texas MD Anderson Cancer Center
2023
Royal Free London NHS Foundation Trust
2023
NHS Lothian
2023
MRC Clinical Trials Unit at UCL
2013-2022
National Institute for Health and Care Excellence
2018-2022
Randomised placebo-controlled trials have shown that daily oral pre-exposure prophylaxis (PrEP) with tenofovir-emtricitabine reduces the risk of HIV infection. However, this benefit could be counteracted by compensation in users PrEP. We did PROUD study to assess effect.
Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is a novel technology formulated as low dose vaccine against COVID-19.
The guidelines are aimed at clinical professionals directly involved in, and responsible for, HIV prevention, community advocates organisations for supporting prevention strategies in those risk of acquisition. A detailed review the evidence base is included Section 4. Sections 5–7 intended to offer practical guidance assessment, starting PrEP, ongoing management while on PrEP stopping PrEP. We recognise importance these being inclusive relevant all, regardless sexuality or gender identity...
HIV pre-exposure prophylaxis (PrEP) is highly effective in preventing acquisition. To enable routine commissioning of PrEP England, we aimed to establish population need, duration uptake, and use attendees sexual health services (SHS) England.
Pre-exposure prophylaxis (PrEP) has proven biological efficacy in reducing the risk of sexual acquisition HIV. Healthcare providers' (HCPs) knowledge and attitudes to PrEP will be key successful implementation. In England, is only available men who have sex with (MSM) through open-label randomized PROUD pilot study immediate or deferred use.In September 2013, a cross-sectional survey UK HCPs distributed health clinics (219) professional societies' email lists (2599) at conference (80) asked...
Pre-exposure prophylaxis (PrEP) has proven biological efficacy to reduce the sexual acquisition of human immunodeficiency virus (HIV). The PROUD study found that PrEP conferred higher protection than in placebo-controlled trials, reducing HIV incidence by 86 % a population with seven-fold expected. We present baseline characteristics and place findings context national health clinic data.The was designed explore real-world effectiveness (tenofovir-emtricitabine) randomising HIV-negative gay...
We report an outbreak of invasive and non-invasive disease due to unusual type Streptococcus pyogenes (group A Streptococcus, emm66) among a vulnerable, largely homeless population in southern England Wales, detected September 2016. Twenty-seven confirmed cases were subsequently identified between 5 January 29 December 2016; 20 injected drugs six reported problematic alcohol use. To date, we have ruled out drug-related vehicles infection few common risk factors.
Pre-exposure prophylaxis (PrEP) is a novel HIV prevention method whereby HIV-negative individuals take the drugs tenofovir and emtricitabine to prevent acquisition. Optimal adherence critical for PrEP efficacy. Chemsex describes sexual activity under influence of psychoactive drugs, in UK typically; crystal methamphetamine, gamma-hydroxybutyrate(GHB) and/or mephedrone. drug use has been associated with increased transmission risk among gay, bisexual other men who have sex (GBM) poor ART...
An increase in acute severe hepatitis of unknown aetiology previously healthy children the UK March, 2022, triggered global case-finding. We aimed to describe epidemiological investigations cases and their possible causes.We actively surveilled unexplained paediatric (transaminase >500 international units per litre) younger than 16 years presenting since Jan 1, through notifications from paediatricians, microbiologists, liver units; we collected demographic, clinical, exposure information....
We characterize the demographics, injection practices and risk behaviours of 1,158 drug users (IDUs) in Chennai, capital Tamil Nadu southern India, who were recruited during 2005-2006 by community outreach. The median age was 35 years; majority IDUs male, ethnicity married, earning less than US$75 per month. Most (76%) had injected prior at first 25 most common heroin (80%) followed buprenorphine. High included needle-sharing, unsafe disposal, inappropriate cleaning needles as well limited...
A new coronavirus SARS-CoV-2 emerged at the start of 2020 with rapid worldwide spread. It is causative agent Coronavirus Disease 2019 (COVID-19). The resulting pandemic has been challenging for centres undertaking autologous and allogeneic haematopoietic stem cell transplants (HSCT). One main risks in HSCT infection susceptibility, including viral infections, which are often more severe life-threatening.1 In response to COVID-19 pandemic, National Institute Health Care Excellence (NICE)...
England has committed to the World Health Organization target eliminate hepatitis C virus (HCV) as a public threat by year 2030. Given successful treatments for HCV in recent years, it is unclear whether reinfection will impact England's ability achieve elimination. We aimed estimate rate among cohort of patients receiving antiviral treatment using available surveillance data. Linkage between dataset from 2015 2019 and an RNA testing were used identify people who experienced three criteria....
In 2015, Bristol (South West England) experienced a large increase in cases of meticillin-resistant Staphylococcus aureus (MRSA) infection people who inject drugs (PWID).We aimed to characterise and estimate the prevalence MRSA colonisation among PWID test evidence clonal outbreak.PWID recruited through an unlinked-anonymous community survey during 2016 completed behavioural questionnaires were screened for MRSA. Univariable logistic regression examined associations with colonisation....
Abstract Background and aims Mortality drug treatment data suggest that the median age of people who inject drugs is increasing. We aimed to describe changes in characteristics injecting United Kingdom (UK). Design Repeat cross‐sectional surveys modelling. Setting Low‐threshold services such as needle syringe programmes. Participants A total 79 900 recently injected psychoactive Kingdom, recruited part Unlinked Anonymous Monitoring Survey (England, Wales, Northern Ireland, 1990–2019) Needle...