A5101824471- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Synthesis and Biological Evaluation
- Helicobacter pylori-related gastroenterology studies
- Mycobacterium research and diagnosis
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- X-ray Diffraction in Crystallography
- Streptococcal Infections and Treatments
- Galectins and Cancer Biology
- Crystallization and Solubility Studies
- Infective Endocarditis Diagnosis and Management
- Neuroscience of respiration and sleep
- Antimicrobial Resistance in Staphylococcus
- Biochemical and Molecular Research
- Microbial Metabolites in Food Biotechnology
- Clostridium difficile and Clostridium perfringens research
- Pharmaceutical and Antibiotic Environmental Impacts
- Platelet Disorders and Treatments
- Legionella and Acanthamoeba research
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Toxin Mechanisms and Immunotoxins
- Bacterial biofilms and quorum sensing
- Glycosylation and Glycoproteins Research
Nottingham Trent University
2023-2025
University of Georgia
2024
University of Dundee
2016-2021
Wellcome Centre for Anti-Infectives Research
2018-2021
Public Health England
2019
Peterborough Regional College
1991
Public Health Laboratory
1991
Newcastle University
1989
University of Newcastle Australia
1987
Visceral leishmaniasis (VL), caused by the protozoan parasites Leishmania donovani and infantum, is one of major parasitic diseases worldwide. There an urgent need for new drugs to treat VL, because current therapies are unfit purpose in a resource-poor setting. Here, we describe development preclinical drug candidate, GSK3494245/DDD01305143/compound 8, with potential this neglected tropical disease. The compound series was discovered repurposing hits from screen against related parasite...
There is an urgent need for new treatments visceral leishmaniasis (VL), a parasitic infection which impacts heavily large areas of East Africa, Asia, and South America. We previously reported on the discovery GSK3494245/DDD01305143 (1) as preclinical candidate VL and, herein, we report medicinal chemistry program that led to its identification. A hit from phenotypic screen was optimized give compound with in vivo efficacy, hampered by poor solubility genotoxicity. The work original scaffold...
Novel treatment options are needed for the gastric pathogen Helicobacter pylori due to its increasing antibiotic resistance. The vitamin K analogue menadione has been extensively studied interest in anti-bacterial and anti-cancer properties. Here, we investigated effects of on H. growth, viability, resistance, motility gene expression using clinical isolates. MIC was 313 µM 11/13 isolates 156 2/13 minimum bactericidal concentrations were 1.25–2.5 mM, indicating that micromolar range...
The leishmaniases are diseases that affect millions of people across the world, in particular visceral leishmaniasis (VL) which is fatal unless treated. Current standard care for VL suffers from multiple issues and there a limited pipeline new candidate drugs. As such, clear unmet medical need to identify treatments. This paper describes optimization phenotypic hit against Leishmania donovani, major causative organism VL. key challenges were balance solubility metabolic stability while...
Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, is most common cause of cardiac-related deaths in endemic regions Latin America. There an urgent need for new safer treatments because current standard therapeutic options, benznidazole and nifurtimox, have significant side effects are only effective acute phase infection with limited efficacy chronic phase. Phenotypic high content screening against intracellular infected VERO cells was used to identify a novel hit series...
In 2015, Bristol (South West England) experienced a large increase in cases of meticillin-resistant Staphylococcus aureus (MRSA) infection people who inject drugs (PWID).We aimed to characterise and estimate the prevalence MRSA colonisation among PWID test evidence clonal outbreak.PWID recruited through an unlinked-anonymous community survey during 2016 completed behavioural questionnaires were screened for MRSA. Univariable logistic regression examined associations with colonisation....
Background Trypanosoma cruzi causes Chagas disease, an endemic and debilitating illness in Latin America. Lately, owing to extensive population movements, this neglected tropical disease has become a global health concern. The two clinically available drugs for the chemotherapy of have rather high toxicity limited efficacy chronic phase may induce parasite resistance. development new anti-T. agents is therefore imperative. enzyme N-myristoyltransferase (NMT) recently been biochemically...
Introduction.Helicobacter pylori is highly polymorphic, and some strains are much more likely to cause disease than others. Biofilm formation can help bacteria survive antibiotic treatment, immune attack other stresses, promoting persistent infection.Hypothesis/Gap Statement. We hypothesized that H. isolates from patients with severe pylori-associated would be better at forming biofilms less disease.Aim. initially aimed determine whether or not the biofilm-forming ability of was associated...
A single clone, Neisseria meningitidis serogroup C (C:2a:P1.2), was isolated from seven patients during a cluster of cases meningococcal disease in Ontario 1989. To determine whether the clone present asymptomatic individuals same population, pharyngeal swabs were taken 7% (644 9125) residents who vaccinated outbreak. Rates isolation species also compared to those two other geographical areas which did not have an elevated incidence disease. The rate carriage N sampled between 1.9% and 5.4%....
Visceral leishmaniasis (VL) is a parasitic infection that results in approximately 26 000–65 000 deaths annually. The available treatments are hampered by issues such as toxicity, variable efficacy, and unsuitable dosing options. need for new urgent led to collaboration between the Drugs Neglected Diseases initiative (DNDi), GlaxoSmithKline (GSK), University of Dundee. An 8-hydroxynaphthyridine was identified start point, an early compound demonstrated weak efficacy mouse model VL but...
Abstract Novel treatment options are needed for the gastric pathogen Helicobacter pylori due to its increasing antibiotic resistance. The vitamin K analogue menadione has been extensively studied interest in antibacterial and anti-cancer properties. Here, we investigated effects of on H. growth, viability, resistance, motility gene expression using clinical isolates. minimum inhibitory concentration (MIC) was 313 µM 11/13 isolates 156 2/13 bactericidal concentrations were 1.25-2.5 mM,...
Abstract The development of drug‐resistant microorganisms is taking a heavy toll on the biomedical world. Clinical infections are costly and becoming increasingly dangerous as bacteria that once responded to standard antibiotic treatment developing resistance mechanisms require innovative strategies. Nitric oxide (NO) gaseous molecule produced endogenously has shown potent antibacterial capabilities in numerous research studies. Its multimechanistic methods prevent have potential an...
Visceral leishmaniasis (VL) affects millions of people across the world, largely in developing nations. It is fatal if left untreated and current treatments are inadequate. As such, there an urgent need for new, improved medicines. In this paper, we describe identification a 6-amino-N-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine scaffold its optimization to give compounds which showed efficacy when orally dosed mouse model VL.
Specific And Accurate Detection Of The Citrus Greening Pathogen Candidatus Liberibacter-spp Using Conventional Pcr On Leaf Tissue Samples - Video. JoVE publishes peer-reviewed scientific video protocols to accelerate biological, medical, chemical and physical research. Watch our articles. is the world-leading producer provider of science videos with mission improve research, journals, education. Millions scientists, educators students at thousands universities, colleges, hospitals...