A5081458584- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Synthesis and Biological Evaluation
- Colorectal and Anal Carcinomas
- Media, Religion, Digital Communication
- Patient-Provider Communication in Healthcare
- Myasthenia Gravis and Thymoma
- Lung Cancer Treatments and Mutations
- Hepatocellular Carcinoma Treatment and Prognosis
- Biochemical and Molecular Research
- Colorectal Cancer Treatments and Studies
- Palliative Care and End-of-Life Issues
- Neuroblastoma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Occupational and environmental lung diseases
- Terrorism, Counterterrorism, and Political Violence
- Pancreatic and Hepatic Oncology Research
- Intraperitoneal and Appendiceal Malignancies
- Pleural and Pulmonary Diseases
- HIV/AIDS drug development and treatment
- Utopian, Dystopian, and Speculative Fiction
University Hospital Heidelberg
2012-2025
Heidelberg University
2011-2025
German Center for Lung Research
2021-2025
Wellcome Centre for Anti-Infectives Research
2018-2024
University of Dundee
2017-2024
Bristol Royal Infirmary
2006-2023
Royal Perth Hospital
2023
University Hospitals Bristol NHS Foundation Trust
2009-2022
University Hospitals Bristol and Weston NHS Foundation Trust
2020-2022
Wellcome Trust
2018
Visceral leishmaniasis (VL), caused by the protozoan parasites Leishmania donovani and infantum, is one of major parasitic diseases worldwide. There an urgent need for new drugs to treat VL, because current therapies are unfit purpose in a resource-poor setting. Here, we describe development preclinical drug candidate, GSK3494245/DDD01305143/compound 8, with potential this neglected tropical disease. The compound series was discovered repurposing hits from screen against related parasite...
Background Colorectal cancer (CRC) is a major cause of worldwide morbidity and mortality. Surgical treatment common, there great need to improve the delivery such care. The gold standard for evaluating surgery within well-designed randomized controlled trials (RCTs); however, impact RCTs diminished by lack coordinated outcome measurement reporting. A solution these issues develop an agreed “core” set outcomes be measured in all facilitate cross-study comparisons, meta-analysis, minimize...
Abstract Background Evidence is emerging that the incidence of colorectal cancer increasing in young adults, but descriptive epidemiology required to better understand these trends currently lacking. Methods A population-based cohort study was carried out including all adults aged 20–49 years diagnosed with England between 1974 and 2015. Data were extracted from National Cancer Registration Analysis Service database using ICD-9/10 codes for cancer. Temporal age-specific rates according sex,...
Visceral leishmaniasis (VL), caused by the protozoan parasites Leishmania donovani and L. infantum, is responsible for ∼30 000 deaths annually. Available treatments are inadequate, there a pressing need new therapeutics. N-Myristoyltransferase (NMT) remains one of few genetically validated drug targets in these parasites. Here, we sought to pharmacologically validate this enzyme Leishmania. A focused set 1600 pyrazolyl sulfonamide compounds was screened against major NMT robust...
There is an urgent need for new treatments visceral leishmaniasis (VL), a parasitic infection which impacts heavily large areas of East Africa, Asia, and South America. We previously reported on the discovery GSK3494245/DDD01305143 (1) as preclinical candidate VL and, herein, we report medicinal chemistry program that led to its identification. A hit from phenotypic screen was optimized give compound with in vivo efficacy, hampered by poor solubility genotoxicity. The work original scaffold...
The exact role and type of surgery for malignant pleural mesothelioma (MPM) remains controversial. This study aimed at analyzing a 20-year single center perioperative experience in MPM our high-volume thoracic comparing the overall survival after trimodal extrapleural pneumonectomy (EPP) extended pleurectomy decortication combined with hyperthermic intrathoracic chemoperfusion (EPD/HITOC) adjuvant chemotherapy that (CTx) alone.Patients epithelioid treated neoadjuvant chemotherapy, EPP...
The leishmaniases are diseases that affect millions of people across the world, in particular visceral leishmaniasis (VL) which is fatal unless treated. Current standard care for VL suffers from multiple issues and there a limited pipeline new candidate drugs. As such, clear unmet medical need to identify treatments. This paper describes optimization phenotypic hit against Leishmania donovani, major causative organism VL. key challenges were balance solubility metabolic stability while...
Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, is most common cause of cardiac-related deaths in endemic regions Latin America. There an urgent need for new safer treatments because current standard therapeutic options, benznidazole and nifurtimox, have significant side effects are only effective acute phase infection with limited efficacy chronic phase. Phenotypic high content screening against intracellular infected VERO cells was used to identify a novel hit series...
Recent data suggest that the incidence of malignant appendiceal tumours is increasing. This study aimed to determine temporal trends in within England and a possible influence by demographic factors.All incident cases patients aged 20 years above were identified from National Cancer Registration Analysis Service database between 1995 2016 using ICD-9/10 codes. Cancers categorized according histology. Joinpoint regression analysis was used investigate changes age-standardized rates age, sex,...
There is an urgent need for new treatments Chagas disease, a parasitic infection which mostly impacts South and Central America. We previously reported on the discovery of GSK3494245/DDD01305143, preclinical candidate visceral leishmaniasis acted through inhibition Leishmania proteasome. A related analogue, active against Trypanosoma cruzi, showed suboptimal efficacy in animal model so alternative proteasome inhibitors were investigated. Screening library phenotypically analogues T. cruzi...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIron carbonyl complexes containing positively charged phosphorus ligandsR. G. Montemayor, Dennis T. Sauer, Suzanne Fleming, W. Bennett, Michael Thomas, and Robert ParryCite this: J. Am. Chem. Soc. 1978, 100, 7, 2231–2233Publication Date (Print):March 1, 1978Publication History Published online1 May 2002Published inissue 1 March 1978https://doi.org/10.1021/ja00475a044RIGHTS & PERMISSIONSArticle Views247Altmetric-Citations46LEARN ABOUT THESE...
The lack of information regarding the mechanisms action (MoA) or specific molecular targets phenotypically active compounds can prove a barrier to their development as chemotherapeutic agents. Here, we report results our orthogonal genetic, molecular, and biochemical studies determine MoA novel 7-substituted 8-hydroxy-1,6-naphthyridine (8-HNT) series that displays promising activity against Trypanosoma brucei Leishmania donovani .
Available treatments for Chagas' disease and visceral leishmaniasis are inadequate, there is a pressing need new therapeutics. Drug discovery efforts both diseases principally rely upon phenotypic screening. However, the optimization of phenotypically active compounds hindered by lack information regarding their molecular target(s). To combat this issue we initiate target deconvolution studies at an early stage. Here, describe comprehensive genetic biochemical to determine targets three...
The accurate staging of colorectal neoplasia may aid the stratification patients for adjuvant treatment. At present mural extent proximal to mid rectum is difficult determine. Prediction invasion could help identify suitable radical resection, minimal access surgery or endoscopic Colonoscopic endoluminal ultrasonography (EUS) was used in a prospective study determine stage rectosigmoid 121 patients.Mural tumour (T) designated by EUS as uT0/1-uT4 patients. Nodal (N) performed 39 cases....
This study was performed to assess the accuracy of colonoscopic endoanal ultrasound scanning (EUS) in selection patients with rectal neoplasia suitable for local excision by transanal endoscopic microsurgery (TEM). Our policy is offer TEM premalignant (T0) lesions or T1 tumours that have early disease.Data were collected prospectively on all undergoing EUS assessment at our institution over a six-year period. A probe used determine whether tumour breached muscularis propria (the interface...