Yee Ting Nicole Yim
A5074577991- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Hematological disorders and diagnostics
- Sepsis Diagnosis and Treatment
- RNA Interference and Gene Delivery
- COVID-19 and Mental Health
- Influenza Virus Research Studies
- Immunotherapy and Immune Responses
- Bacterial Infections and Vaccines
UCL Biomedical Research Centre
2022-2023
University College London
2021-2022
Hospital for Tropical Diseases
2021
Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is a novel technology formulated as low dose vaccine against COVID-19.
Summary: Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is a novel technology formulated as low dose vaccine against COVID-19.Methods: A phase I first-in-human dose-ranging trial of saRNA COVID-19 candidate LNP-nCoVsaRNA, was conducted at Imperial Clinical Research Facility, and participating centres in London, UK. Participants received two intramuscular (IM) injections LNP-nCoVsaRNA six different levels, 0·1-10·0mg, given four weeks apart. An open-label escalation...
Lipid nanoparticle (LNP) encapsulated self-amplifying RNA (saRNA) is well tolerated and immunogenic in SARS-CoV-2 seronegative seropositive individuals aged 18-75.Methods: A phase 2a expanded safety immunogenicity study of a saRNA vaccine candidate LNP-nCoVsaRNA, was conducted at participating centres the UK. Participants received 1mg then 10mg ~14 weeks apart.Solicited adverse events (AEs) were collected for one week post-each vaccine, unsolicited AEs throughout. Binding neutralisating...
A proportion of patients with pyrexia unknown origin (PUO), or inflammation (IUO), are without a diagnosis following extensive clinical and laboratory evaluation.1-3 The outcome in this group is variable; those significant systemic may have prolonged hospital stays high mortality rate. Many shown that the prognosis dependent on diagnosis, which key to determining outcomes these patients.4, 5 Clinical practice setting highly variable but often includes trial steroids. This initial therapeutic...