A5100369479- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Hydrology and Watershed Management Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Gene expression and cancer classification
- Circular RNAs in diseases
- Soil erosion and sediment transport
- Lung Cancer Treatments and Mutations
- PARP inhibition in cancer therapy
- Aeolian processes and effects
- Invertebrate Immune Response Mechanisms
- BRCA gene mutations in cancer
- Curcumin's Biomedical Applications
- Advanced Fluorescence Microscopy Techniques
- Pregnancy-related medical research
- Chromosomal and Genetic Variations
- Sustainable Agricultural Systems Analysis
- Reproductive System and Pregnancy
Qinghai University
2025
Liaoning Cancer Hospital & Institute
2022-2024
China Three Gorges University
2024
Wuhan Botanical Garden
2024
Ministry of Agriculture and Rural Affairs
2024
Southwestern Medical Center
2023
The University of Texas Southwestern Medical Center
2023
City Of Hope National Medical Center
2023
Second Affiliated Hospital of Guangzhou Medical University
2022
Guangdong Medical College
2022
MicroRNAs have been considered as a kind of potential novel biomarker for cancer detection due to their remarkable stability in the blood and characteristics expression profile many diseases.We performed microarray-based serum miRNA profiling on twenty nasopharyngeal carcinoma patients at diagnosis along with 20 non-cancerous individuals controls. This was followed by real-time quantitative Polymerase Chain Reaction (RT-qPCR) separate cohort thirty age- matched volunteers. A model...
An increasing number of studies focus on the effectiveness Massive Open Online Courses (MOOC)-based blended learning, whereas none have yet studied using it for teaching fundamental nursing skills at an undergraduate level.To evaluate MOOC-based learning versus face-to-face classroom techniques within course Faculty Nursing, University Xiang Nan, China.This cluster randomized controlled trial enrolled 181 students and assigned them into either or a group, both involving Fundamental Nursing...
This study investigates the level of sustainable development, evolution patterns, and obstacles in Qinghai Province. Considering province’s unique characteristics ecological significance, we have established an evaluation indicator system based on DPSIR model. The entropy weight–TOPSIS model is used to assess overall sustainability from 2008 2022. grey GM(1,1) predict future trends, while coupling coordination quantifies degree among subsystems. Furthermore, barrier explore factors hindering...
Abstract Cancer is a complex disease, which may involve multiple tumor susceptibility genes that mediate the occurrence and development of molecular events. This study aimed to identify new genetic loci using genome-wide linkage analysis whole-exome sequencing in rare, large multi-cancer pedigree recently found China. We performed high-throughput single-nucleotide polymorphism (SNP) array analyses 24 core members this disease locus was mapped chromosome 3q24-26. also used microsatellites...
Importance The inability to obtain a pathological diagnosis in certain proportion of patients with clinically diagnosed advanced lung cancer impedes precision treatment clinical practice. Objective To evaluate the outcome first-line icotinib unknown status and positive epidermal growth factor receptor ( EGFR )–sensitizing variants assessed by circulating tumor DNA (ctDNA). Design, Setting, Participants Efficiency Icotinib Plasma ctDNA Mutation-Positive Patients Diagnosed With Lung Cancer...
Approximately 85% colorectal cancers (CRCs) are thought to evolve through the adenoma‐to‐carcinoma sequence associated with specific molecular alterations, including 5‐hydroxymethylcytosine (5hmC) signature in circulating cell‐free DNA (cfDNA). To explore disease progression and evaluate use of cfDNA as a potential diagnostic factor for CRC screening, here, we performed genome‐wide 5hmC profiling plasma tissue genomic (gDNA) acquired from 101 samples (63 38 tissues), collected 21 early‐stage...
When faced with a case of bilateral breast cancer (BBC), understanding how to differentiate primary from contralateral metastatic is essential for treatment, but clear identification criteria have not been established date. Diverse events play different roles in the therapy and prognosis BBC; hence, it great significance detect more comprehensive convincing technique make an accurate differential diagnosis. We report rare synchronous BBC 61-year-old Chinese woman. Based on her clinical...
Breast cancers can be divided into HER2-negative and HER2-positive subtypes according to different status of HER2 gene. Despite extensive studies connecting germline mutations with possible risk breast cancer, the main category it remains challenging obtain accurate assessment understand potential underlying mechanisms.We developed a novel framework named Damage Assessment Genomic Mutations (DAGM), which projects rare coding gene expressions Activity Profiles Signalling Pathways (APSPs).We...
Colon cancer and colorectal are two common cancer-related deaths worldwide. Identification of potential biomarkers for the cancers can help us to evaluate their initiation, progression therapeutic response. In this study, we propose a new microRNA-disease association identification method, BNNRMDA, discover microRNA cancers. BNNRMDA better combines disease semantic similarity Gaussian Association Profile Kernel (GAPK) similarity, function GAPK bound nuclear norm regularization model....
Ectopic pregnancy (EP) is associated with significant morbidity and mortality, but the molecular mechanism of this condition still unclear. miR-196b, a hot research direction for past few years, participates in occurrence various diseases whether it plays regulatory role EP This was set to investigate expression potential value miR-196b EP. qRT-PCR utilized determine relative peripheral blood patients observe changes before after treatment. Correlation analysis HCG progesterone performed....
Abstract Introduction IMpower151 (NCT04194203) was a phase 3 study to evaluate the efficacy and safety of atezolizumab, bevacizumab, carboplatin, plus paclitaxel or pemetrexed (ABCP) vs BCP, as 1L treatment for metastatic nsqNSCLC. did not meet its primary endpoint INV-PFS. The objectives this biomarker analysis were characterize molecular subtypes nsqNSCLC explore relationship between subtype, predefined gene expression signatures, PD-L1 status clinical outcomes with ABCP BCP. Methods RNA...
Parasitic infestations present significant threats to the physiological health and ecological stability of aquatic species, frequently compromising immune defenses elevating mortality rates. This study was conducted elucidate non-specific responses induced by Pallisentis (Neosentis) celatus infection in Monopterus albus, with a focus on intestinal histopathology transcriptome gene expression. A histopathological examination revealed minor alterations villi under low-level infection....
Abstract Introduction: Recently, methylation sequencing has drawn significant attention as it shown great promise for cancer detection and relapse surveillance. However, with any low-input method, quality control is critical implementation into the clinic, difficult to obtain a sustainable source of patient samples validation activities. To address these unmet needs, here we describe design fit-for-purpose cfDNA Methylation Reference Standards (MRS) evaluate performance cfDNA-based tests...
Abstract Tumor mutational burden and heterogeneity fuel resistance to many targeted therapies, which inevitably limits the clinical outcome of patients. The cytosine deaminase APOBEC proteins are major drivers mutagenesis in human cancer, with over 70% tumors exhibiting a signature that is impacted by activity. Nevertheless, mechanisms through tumor cells hijack powerful machinery promote therapy remain largely unknown. Through multi-disciplinary approach integrating bulk single cell RNA-Seq...
Abstract Tumor mutational burden and heterogeneity fuel resistance to many targeted therapies, which inevitably limits the clinical outcome of patients. The cytosine deaminase APOBEC proteins are major drivers mutagenesis in human cancer, with over 70% tumors exhibiting a signature that is impacted by activity. Nevertheless, mechanisms through tumor cells hijack powerful machinery promote therapy remain largely unknown. Through multi-disciplinary approach integrating bulk single cell RNA-Seq...
Abstract Early identification of the risk for triple-negative breast cancer (TNBC) at asymptomatic phase could lead to better prognosis. Here we developed a machine learning method quantify systematic impact all rare germline mutations on each pathway. We collected 106 TNBC patients and 287 elder healthy women controls. The spectra activity profiles in multiple pathways were mapped most pathway activities exhibited globally suppressed by portfolio individual patients. Accordingly,...
Abstract Colorectal cancer (CRC) is a serious malignancy with the third incidence and second mortality throughout world. 5-Hydroxymethylcytosine (5hmC) signatures in circulating cell-free DNA (cfDNA) an important epigenetic mark linked human pathogenesis. Here we explored genome-wide 5-hydroxymethylcytosine profiling plasma cfDNA tissue genomic (gDNA) acquired from 101 samples (63 38 tissues), collected 21 CRC patients, precancerous adenoma (AD) patients healthy control individuals (HC)....