A5100404493- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Breast Lesions and Carcinomas
- Epigenetics and DNA Methylation
- Cancer Risks and Factors
- Analytical chemistry methods development
- PI3K/AKT/mTOR signaling in cancer
- Bone and Joint Diseases
- Barrier Structure and Function Studies
- Cancer-related Molecular Pathways
- Acute Kidney Injury Research
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- BRCA gene mutations in cancer
- Mycobacterium research and diagnosis
- Geochemistry and Geologic Mapping
- Cancer, Hypoxia, and Metabolism
Dalian Medical University
2018-2024
Second Affiliated Hospital of Dalian Medical University
2018-2024
Southern Medical University
2015-2024
Zhujiang Hospital
2015-2024
Jinzhou Medical University
2022
Northwest A&F University
2022
Guangzhou Medical University
2022
First Affiliated Hospital of Bengbu Medical College
2022
Sun Yat-sen University
2022
Wuhan University
2022
Abstract Background Taurine upregulated gene1 (TUG1) as a 7.1-kb lncRNA, has been shown to play an oncogenic role in various cancers. However, the biological functions of lncRNA TUG1 small cell lung cancer (SCLC) remain unknown. The aim this study is explore roles growth and chemoresistance SCLC its possible molecular mechanism. Methods expression thirty-three cases tissues line were examined by quantitative RT-PCR (qRT-PCR). functional demonstrated CCK8 assay, colony formation wound healing...
The mechanism of blood-brain barrier (BBB) disruption, involved in poststroke edema and hemorrhagic transformation, is important but elusive. We investigated microRNA-150 (miR-150)-mediated the disruption BBB after stroke rats. found that up-regulation miR-150 increased permeability as detected by MRI permanent middle cerebral artery occlusion vivo well brain microvascular endothelial cells oxygen-glucose deprivation vitro. expression claudin-5, a key tight junction protein, was decreased...
The long non-coding RNA (lncRNA) HOX transcript antisense (HOTAIR) serves as a powerful predictor of tumor progression and overall survival in patients. Our previous studies showed that HOTAIR modulated HOXA1 DNA methylation by reducing DNMT1 DNMT3b expression drug-resistant small cell lung cancer (SCLC). Moreover, H3 lysine 27 trimethylation (H3K27me3) is catalyzed enhancer zeste homolog 2 (EZH2) plays critical role SCLC chemoresistance. However, it not completely clear whether H3K27me3...
Abstract Long noncoding RNAs (lncRNAs) played an important role in tumorigenesis and development of hepatocellular carcinoma (HCC). In this study, we first demonstrated that lncRNA DLX6 antisense RNA 1 (DLX6‐AS1) was upregulated cancer tissues cells lines compared with normal adjacent cell line. Knock‐down DLX6‐AS1 by transfection small interfering (siRNA) suppressed proliferation, migration, invasion HCC cells. Cell cycle analysis showed transfected siRNA were arrested G0/G1 phase. Then,...
Septic patients suffer a 'cytokine storm' from proinflammatory cytokines, chemokines and other inflammatory mediators, resulting in acute kidney injury (AKI) death. The purpose of the present study was to determine expression patterns microRNA-210 (miR-210), miR-494, miR-205 middle-aged old with sepsis-induced AKI evaluate their association patient prognosis. Serum blood urea nitrogen (BUN), creatinine (Cr) cystatin C levels were determined peripheral venous collected 110 healthy controls....
Background: LncRNA AWPPH is a recently identified critical player in the development of several types human malignancies, our study aimed to investigate role triple-negative breast cancer. Methods: In present study, expression tumor tissues and adjacent healthy patients with cancer as well plasma both people was detected by qRT-PCR. Application potentials diagnosis prognosis were evaluated ROC curve analysis survival analysis, respectively. vectors frizzled homolog 7 (FZD7) siRNAs...
Breast cancer is the most common malignant tumor among women in world. In 2005, there were approximately 272,000 new cases diagnosed and more than 70,000 deaths from breast China. Of patients who are newly with each year, 3% to 10% have distant metastases at time of diagnosis. those early stage disease diagnosis, 30% 40% will develop advanced cancer. The 5‐year survival rate for only 20%, median overall (OS) 2 3 years. Although still difficult cure, physicians can relieve clinical symptoms,...
ESR1 mutations are frequently detected in ER+ MBC, and have been reported to be associated with endocrine therapy resistance. However, there little researches validate whether dynamic monitoring of could serve as a predictive plasma biomarker acquired resistance therapy. Therefore, this study, we performed longitudinal circulating tumor DNA (ctDNA) detection evaluate the clinical implications mutations.We mutation analyses samples from 45 patients metastatic breast cancer (MBC) sequencing...
Drug resistance is one of the main causes chemotherapy failure in patients with small cell lung cancer (SCLC), and extensive biological studies into drug are required. In this study, we performed lncRNA microarray, vitro functional assays, vivo models cDNA microarray to evaluate impact SCLC chemoresistance. The results showed that KCNQ1OT1 expression was upregulated tissues a poor prognostic factor for SCLC. Knockdown inhibited proliferation, migration, chemoresistance promoted apoptosis...
STIL is an important cell cycle-regulating protein specifically recruited to the mitotic centrosome promote replication of centrioles in dividing cells. However, potential role regulation biological functions triple-negative breast cancer remains still unclear. We screened for differentially expressed Cancer Genome Atlas database. The expression 10 pairs tissues and adjacent normal was further assessed by western blotting. Functionally, knockdown overexpression have been used explore effects...
Pancreatic cancer is a malignant tumor of the digestive tract, rendering it difficult to make an accurate diagnosis. The 5 year survival rate for pancreatic <1%, and surgical resection rarely proves be effective. Therefore, identification more effective methods early detection urgent requirement. present study aimed explore key genes microRNAs (miRNAs) associated with pathogenesis cancer. Public databases were searched, data integrated from Cancer Genome Atlas Gene Expression Omnibus...
Numerous studies have suggested that non‑coding RNAs mediate tumorigenesis via the epithelial‑mesenchymal transition (EMT). However, whether long RNA (lncRNA) HOXA transcript at distal tip (HOTTIP) plays a role in EMT of small cell lung cancer (SCLC) remains unclear. The results present study suggest HOTTIP‑knockdown may lead to significant increase E‑cadherin expression and decrease vimentin (VIM) expression; these proteins are two key markers EMT. Furthermore, notable morphological change...
Abstract Recent studies show that lncRNAs participate in drug resistance and nonsmall cell lung cancer (NSCLC) progression. This study aimed to the roles mechanisms of long intergenic nonprotein coding RNA 01140 (LINC01140) regulating NSCLC progression resistance. Real‐time quantitative polymerase chain reaction western blot analysis were used detect LINC01140, miR‐4742‐5p, transforming acidic coiled‐coil 1 (TACC1) expression cells. The interaction between two molecules was examined by...
Abstract The main purpose of this study was to build a prediction model for patients with contralateral breast cancer (CBC) using competing risks methodology. aim is help clinicians predict the probability CBC in (BC) survivors. We reviewed data from Surveillance, Epidemiology, and End Results database 434,065 BC. Eligible were used quantify association between development multiple characteristics BC risk models. A nomogram also created facilitate clinical visualization analysis. Finally,...
Background: The aim of this study was to construct a glycolysis-related long noncoding RNA (lncRNA) signature predict the prognosis patients with gastric cancer (GC). Methods: Glycolysis-related genes were obtained from Molecular Signatures Database (MSigDB), lncRNA expression profiles and clinical data GC Cancer Genome Atlas database (TCGA). Furthermore, univariate Cox regression analysis, Least Absolute Shrinkage Selection Operator (LASSO) multivariate analysis used prognostic signature....
To investigate the clinical characteristics and clinicopathological correlations of bilateral breast cancer (BBC) in China.Data 440 patients diagnosed with BBC 2018 were collected from 33 centers Chinese Society Breast Surgery. Demographic characteristics, tumor comprehensive treatment data obtained. Correlations between tumors analyzed.The proportion was 0.22%-3.08%. A total (7.5%) had a family history malignant tumors, 304 (69.1%) synchronous BBC. Only 1 (0.2%) patient male. More than half...
Abstract Colorectal cancer (CRC) is a serious malignancy with the third incidence and second mortality throughout world. 5-Hydroxymethylcytosine (5hmC) signatures in circulating cell-free DNA (cfDNA) an important epigenetic mark linked human pathogenesis. Here we explored genome-wide 5-hydroxymethylcytosine profiling plasma cfDNA tissue genomic (gDNA) acquired from 101 samples (63 38 tissues), collected 21 CRC patients, precancerous adenoma (AD) patients healthy control individuals (HC)....