A5101660252- Cancer-related molecular mechanisms research
- Insect Resistance and Genetics
- Lung Cancer Research Studies
- RNA modifications and cancer
- Insect symbiosis and bacterial influences
- Epigenetics and DNA Methylation
- Natural Language Processing Techniques
- Hippo pathway signaling and YAP/TAZ
- Topic Modeling
- Biomedical Text Mining and Ontologies
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Insect-Plant Interactions and Control
- Machine Learning in Healthcare
- Genomics and Phylogenetic Studies
- Ubiquitin and proteasome pathways
- Cancer Genomics and Diagnostics
- Antimicrobial Peptides and Activities
- Text and Document Classification Technologies
- Artificial Intelligence in Healthcare
- Mycobacterium research and diagnosis
- Machine Learning in Bioinformatics
- Bamboo properties and applications
- Wnt/β-catenin signaling in development and cancer
- IL-33, ST2, and ILC Pathways
Sichuan University
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Institut de Biologia Evolutiva
2023
Universitat Pompeu Fabra
2023
Rice University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2017-2022
Lanzhou Jiaotong University
2022
Sichuan Academy of Forestry
2022
Xi'an Jiaotong University
2017
Zhujiang Hospital
2014-2016
The process of matching patients with suitable clinical trials is essential for advancing medical research and providing optimal care. However, current approaches face challenges such as data standardization, ethical considerations, a lack interoperability between Electronic Health Records (EHRs) trial criteria. In this paper, we explore the potential large language models (LLMs) to address these by leveraging their advanced natural generation capabilities improve compatibility EHRs...
Understanding how large language models (LLMs) acquire, retain, and apply knowledge remains an open challenge. This paper introduces a novel framework, K-(CSA)^2, which categorizes LLM along two dimensions: correctness confidence. The framework defines six categories of knowledge, ranging from highly confident to confidently held misconceptions, enabling nuanced evaluation model comprehension beyond binary accuracy. Using this we demonstrate techniques like chain-of-thought prompting...
Rare diseases are challenging to diagnose due limited patient data and genetic diversity. Despite advances in variant prioritization, many cases remain undiagnosed. While large language models (LLMs) have performed well medical exams, their effectiveness diagnosing rare has not been assessed. To identify causal genes, we benchmarked various LLMs for gene prioritization. Using multi-agent Human Phenotype Ontology (HPO) classification, categorized patients based on phenotypes solvability...
Large language models (LLMs) have achieved remarkable success in contextual knowledge understanding. In this paper, we show that these concentrated massive values consistently emerge specific regions of attention queries (Q) and keys (K) while not having such patterns (V) various modern transformer-based LLMs (Q, K, V mean the representations output by query, key, value layers respectively). Through extensive experiments, further demonstrate play a critical role interpreting (knowledge...
Generative AI models, renowned for their ability to synthesize high-quality content, have sparked growing concerns over the improper generation of copyright-protected material. While recent studies proposed various approaches address copyright issues, capability large vision-language models (LVLMs) detect infringements remains largely unexplored. In this work, we focus on evaluating detection abilities state-of-the-art LVLMs using a set image samples. Recognizing absence comprehensive...
Abstract Background Our previous research found that YAP1 may have a role in multidrug resistance (MDR) small cell lung cancer (SCLC). However, its underlying mechanism is unknown. Methods In this study, we investigated the expression of using immunohistochemical staining and assessed relationship between overall survival patients with SCLC. We established H69 stable lines overexpressed constitutively active H446 dominate negative YAP1. conducted CCK‐8, flow cytometric analysis, vivo...
Our previous study indicated that WW domain binding protein 5 (WBP5) expression was elevated significantly in a drug-resistant cell compared with its parental cell. Nevertheless, functional role and underlying mechanisms remain unknown. In this study, WBP5 examined 62 small lung cancer (SCLC) patient samples by immunohistochemical technique. Stable WBP5-overexpressed WBP5-underexpressed cells were further established to assess the of drug resistance, apoptosis tumour growth. We also...
Immune checkpoint inhibitors (ICIs) are an important treatment modality that must be considered for patients with lung adenocarcinoma (LUAD). However, ICIs effective only in some of these patients. Therefore, identifying biomarkers accurately predict the prognosis LUAD treated can help maximize their therapeutic benefits. This study aimed to identify a new potential predictor better select and optimally benefit patients.We first collected analyzed discovery immunotherapy cohort comprising...
Spodoptera litura is an important polyphagous pest that causes significant damage to the agricultural sector. We performed RNA-seq of 15 S. individuals from larval (fifth and sixth instar larvae), chrysalis, adult developmental stages. also compared transcriptome data with frugiperda across same stages, which was sequenced in our previous study.A total 101,885 differentially expressed transcripts (DETs) were identified litura. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG)...
Although the Hippo pathway and CD133 have been reported to play pertinent roles in a variety of cancer, knowledge about their contribution radiation resistance small-cell lung cancer (SCLC) is limited. In this first-of-a-kind study, we expression key proteins SCLC patients by immunohistochemical staining. We assessed involvement yes-associated protein 1 (YAP1) Cell Counting Kit-8 (CCK-8) flow cytometry. addition, analysed impact on radiotherapy for SCLC. The mammalian Ste20-like...
Pikas (Lagomorpha: Ochotonidae) are small mouse-like lagomorphs. To investigate their adaptation to different ecological environments during dispersal from the Qinghai-Xizang (Tibet) Plateau (QTP), we collected 226 pikas and measured 20 morphological characteristics recorded habitat information. We also sequenced genome of 81 specimens, representing 27 putative pika species. The genome-wide tree based on 4 090 coding genes identified five subgenera, i.e., Alienauroa, Conothoa, Lagotona,...
During the breast-feeding period, infants undergo remarkable changes, including rapid physiological and developmental growth. However, little is known about gene expression features sex-specific in infants. In this study, we sequenced 32 blood transcriptomes from 16 rhesus macaque (<i>Macaca mulatta</i>) their lactating mothers. We identified 218 differentially expressed genes (DEGs) between mothers, 91 up-regulated 127 down-regulated DEGs infant group. Functional enrichment analysis of...
Tumor microenvironment (TME) cells play important roles in tumor progression. Accumulating evidence show that they can be exploited to predict the clinical outcomes and therapeutic responses of tumor. However, role immune genes TME small cell lung cancer (SCLC) is currently unknown.To determine SCLC.We downloaded expression profile follow-up data SCLC patients from Gene Expression Omnibus (GEO), infiltration 158 using CIBERSORT. The correlation between phenotypes, genomic features,...
Summary The Tibetan chicken is a native Chinese breed that lives at high elevations and has adapted to the extreme environmental conditions of Plateau. However, its hypoxic adaptation gene expression level unclear. Here, we sequenced nine lung transcriptomes three developmental stages (5 42 weeks 4.5 years). A total 1.02 billion clean reads were obtained. We identified 16 012 mRNAs 6898 lncRNAs. mRNA showed samples significantly divided into clusters, with higher correlation closer...
Toads release toxic dry secretions from glands in their skin. Toxin possesses a wide range of biological effects, but little is known about its specific gene expression pattern and regulatory mechanisms. The Asiatic toad ( Bufo gargarizans ) widely used to produce toxin. Here, we explored the 30 tissue samples three different skin sites (parotoid gland, dorsal skin, abdomen skin) B. . After de novo assembly, 783,130 unigenes with an average length 489 bp (N50 = 556 bp) were obtained. A total...
Abstract Background In sarcomas, the DNA copy number and methylation exhibit genomic aberrations. Transcriptome imbalances play a driving role in heterogeneous progression of sarcomas. However, it is still unclear whether abnormalities numbers are systematically related to epigenetic methylation, thus, comprehensive analysis sarcoma occurrence development from perspective genomics required. Methods RNASeq, variation (CNV), data, clinical follow-up information were obtained The Cancer Genome...
Abstract The Heilongjiang brown frog ( Rana amurensis ) is widely used in traditional Chinese medicine. In particular, the oviduct and skin have been developed into various health products. However, limited numbers of complete genomes amphibian species reported, excluding frog. Here, transcriptomes 45 samples from liver, spleen, heart, ovaries, thigh muscles, skin, oviduct, stomach intestine five were reassembled analyzed. A total 1,085,532 unigenes with an average length 676.6 bp N50 722...
Spodoptera litura is an important polyphagous pest that causes great damage to agriculture. We performed RNA-seq from 15 individuals of S. litura, including different larval (fifth and sixth instar larvae), chrysalis, adult developmental stages. also sequenced the frugiperda compared with litura. A total 101,885 differentially expressed transcripts (DETs) were identified in Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses indicated may undergo active development...
The gut microbiota contributes to host health by facilitating nutrient uptake, digestion, energy metabolism, intestinal development, vitamin synthesis, and immunomodulation, plays an important role in the growth reproduction of animal itself. Considering paucity research on wild snakes, this study focused bamboo pitviper (Viridovipera stejnegeri) populations from Anhui, Guizhou, Hunan, with multiple fecal samples collected each population (six, five, three, respectively). Total microbial DNA...