A5052453000- Ovarian function and disorders
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Reproductive Biology and Fertility
- Microbial Metabolic Engineering and Bioproduction
- Endometriosis Research and Treatment
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Phagocytosis and Immune Regulation
- Advancements in Battery Materials
- Circular RNAs in diseases
- Biofuel production and bioconversion
- Per- and polyfluoroalkyl substances research
- Animal Genetics and Reproduction
- Birth, Development, and Health
- Nerve injury and regeneration
- Neonatal Respiratory Health Research
- Mitochondrial Function and Pathology
- Advanced Battery Materials and Technologies
- Epigenetics and DNA Methylation
- Enzyme Catalysis and Immobilization
- Neonatal and fetal brain pathology
- Adenosine and Purinergic Signaling
- Genetic Neurodegenerative Diseases
- Immune Cell Function and Interaction
Jiangnan University
2020-2024
Yangzhou University
2021-2024
Renji Hospital
2014-2024
Shanghai Jiao Tong University
2014-2024
Central South University
2016-2024
University of Miami
2015-2024
Zhengzhou University
2023-2024
Indiana University – Purdue University Indianapolis
2017-2024
Indiana University School of Medicine
2017-2024
Shaanxi Normal University
2024
The mammalian target of rapamycin (mTOR) positively regulates axon growth in the central nervous system (CNS). Although regeneration and functional recovery from CNS injuries are typically limited, knockdown or deletion PTEN, a negative regulator mTOR, increases mTOR activity induces robust regeneration. It has been suggested that inhibition S6 kinase 1 (S6K1, gene symbol: RPS6KB1), prominent target, would blunt mTOR's positive effect on growth. In contrast to this expectation, we...
Abstract STUDY QUESTION Does ovarian ferroptosis play an active role in the development of polycystic ovary syndrome (PCOS)? SUMMARY ANSWER Increased was present PCOS ovaries and inhibition with ferrostatin-1 (Fer-1) ameliorated morphology anovulation. WHAT IS KNOWN ALREADY Programmed cell death plays a fundamental follicle development. However, types mechanisms involved are yet to be elucidated. Ferroptosis is recently discovered iron-dependent programmed death. Impaired iron metabolism...
The oleaginous non-conventional yeast Yarrowia lipolytica has enormous potential as a microbial platform for the synthesis of various bioproducts. However, while model Saccharomyces cerevisiae very high homologous recombination (HR) efficiency, non-homologous end-joining is dominant in Y. lipolytica, and foreign genes are randomly inserted into genome. Consequently, low HR efficiency greatly restricts genetic engineering this yeast. In study, RAD52, key component machinery S. cerevisiae, was...
The growing applications of wearable electronics, electronic textiles, and biomedical devices have sparked explosive demand for high-performance flexible sensors. Herein, we report a facile approach fabricating highly sensitive carbon hybrid fiber, which is composed graphene fiber skeleton nanotube (CNT) branches. In this hierarchical in situ grown CNTs prohibit the stacking sheets bridge layers simultaneously, making fluffy conductive. Due to well-designed architecture, assembled sensor...
Endometrial decidualization is a prerequisite for implantation, and impaired associated with recurrent implantation failure (RIF). Coding genes of the HOX family have been clarified as critical regulators in endometrial decidualization, but role long non-coding RNAs (lncRNAs) gene has yet to be determined. The aim this study was clarify possible roles lncRNAs decidualization. In study, we identified that HOXA11-AS most reduced lncRNA human endometrium during window it elevated RIF patients....
The present study aimed to examine the expression and function of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)/microRNA (miR)-146a/nuclear factor (NF)-κB axis in lipopolysaccharide (LPS)-induced acute kidney injury (AKI). mRNA levels MALAT1 miR-146a AKI tissues cells were detected using reverse transcription-quantitative polymerase chain reaction analysis. NF-κB pathway proteins cell viability assessed western blot analysis MTT method, respectively. secretion inflammatory...
We aimed to investigate the incidence and risk factors associated with nonselective removal of peripherally inserted central venous catheter (PICC) in neonates. In this prospective cohort study, neonates who underwent PICC placement at neonatal intensive care units (NICUs) China from October 2012 November 2015 were included. The patient demographics, characteristics, duration, insertion site, indication for insertion, infuscate composition, tip location, complications recorded a computerized...
Background and Purpose- Ischemic stroke, a complex heterogeneous disease, is the second leading cause of death worldwide. Genetic factors epigenetic modification contribute to pathogenesis this disease. However, effects on disease have not been systematically investigated. Our study was designed identify methylation alterations in large-artery atherosclerotic stroke. Methods- We conducted an epigenome-wide association analysis stroke using Infinium HumanMethylation450 array...
This review comprehensively summarizes the latest progress as well challenges and prospects of Cu-based catalysts for electroreduction carbon dioxide.
Septic patients suffer a 'cytokine storm' from proinflammatory cytokines, chemokines and other inflammatory mediators, resulting in acute kidney injury (AKI) death. The purpose of the present study was to determine expression patterns microRNA-210 (miR-210), miR-494, miR-205 middle-aged old with sepsis-induced AKI evaluate their association patient prognosis. Serum blood urea nitrogen (BUN), creatinine (Cr) cystatin C levels were determined peripheral venous collected 110 healthy controls....
The insulin resistance (IR) of ovarian granulosa cells from polycystic ovary syndrome (PCOS) aggravates the abnormalities in steroidogenesis and anovulation, chemerin is an adipokine involved regulating adipogenesis glucose homeostasis. role underlying mechanism developing IR PCOS remain unclear. Plasma, follicular fluid, human granulosa-lutein (hGLs) were collected non-PCOS patients with or without IR. levels elevated both fluid hGL samples IR, hGLs showed decreased sensitivity impaired...
Chemical etching of metals generally brings about undesirable surface damage accompanied by deteriorated performance. However, new possibilities in view structured interfaces and functional surfaces can be explored wisely incorporating corrosion chemistry. Here, an ultrafast route to scalable Al foils with desired porous structures originating from Fe(III)-induced oxidation was presented. Coupling efficient electron polarization involving microwave interaction, straightforward engineering is...
The accumulation of abnormal proteins is a common characteristic neurodegenerative diseases. This reflects severe disturbance cellular homeostasis in pathogenic protein clearance. Here, we demonstrated that the activation two major proteolytic machineries, molecular chaperone–ubiquitin proteasome system (UPS) and autophagy system, were simultaneously enhanced by paeoniflorin (PF), component Paeonia plants, exerted therapeutic effects models spinal bulbar muscular atrophy (SBMA). PF...
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine known to regulate cell growth, differentiation, and motility potent modulator of immune function. TGF-β consequently plays central role in carcinogenesis, dampened TGF-β2 response by Theileria annulata-infected monocytes/macrophages underpins disease resistance tropical theileriosis. Here, we show that concomitant with the loss production, there ablated expression COX2 EP4, which leads drop cyclic AMP (cAMP) levels and,...