A5078856013- Ovarian function and disorders
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Retinoids in leukemia and cellular processes
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Estrogen and related hormone effects
- Sperm and Testicular Function
- Reproductive tract infections research
- Assisted Reproductive Technology and Twin Pregnancy
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- RNA modifications and cancer
- Gut microbiota and health
- Lipid metabolism and disorders
- Circadian rhythm and melatonin
- Gene expression and cancer classification
- Chronic Lymphocytic Leukemia Research
- Protein Degradation and Inhibitors
- Pelvic floor disorders treatments
- Axon Guidance and Neuronal Signaling
Renji Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Shandong University
2018-2020
Shandong Provincial Hospital
2018
Guangxi Maternal and Child Health Hospital
2018
Penn State Milton S. Hershey Medical Center
2018
Yale University
2018
Shandong Agricultural University
2017
Chinese Academy of Sciences
2004-2016
Shanghai Institutes for Biological Sciences
2004-2016
Understanding the complexity and dynamics of cancer cells in response to effective therapy requires hypothesis-driven, quantitative, high-throughput measurement genes proteins at both spatial temporal levels. This study was designed gain insights into molecular networks underlying clinical synergy between retinoic acid (RA) arsenic trioxide (ATO) acute promyelocytic leukemia (APL), which results a high-quality disease-free survival most patients after consolidation with conventional...
Are telomere length and telomerase activity associated with biochemical primary ovarian insufficiency (POI)?Shortened diminished were POI.POI is a result of pathological reproductive aging encompasses occult, overt stages. Studies have indicated as biomarker for biological aging.A total 120 patients POI 279 control women recruited by the Center Reproductive Medicine Shandong University.Telomere in peripheral blood leukocytes (LTL) granulosa cells (GTL) was measured using modified...
To better understand possible effects of bisphenol A (BPA) exposure on ovarian reserve in women with polycystic ovary syndrome (PCOS), we measured creatinine adjusted urinary BPA (BPA_Cre) concentrations and used regression models to evaluate the association between level antral follicle count (AFC), antimullerian hormone (AMH), day-3 stimulating levels (FSH) inhibin B (INHB) 268 infertile diagnosed PCOS. was detected all a median concentration 2.35 ng/mL (the 25th 75th percentiles 1.47 3.95...
The characteristics of polycystic ovary syndrome (PCOS), a common reproductive endocrinal disorder, are high incidence, complicated aetiology and poor therapeutic effects. PCOS patients frequently exhibit gut dysbiosis; however, its roles in the regulation metabolic balances pathophysiology not clear.In this study, dysbiosis was reproduced dehydroepiandrosterone (DHEA)-induced PCOS-like rats. An antibiotic cocktail used to eliminate microbiota during DHEA treatment; depletion did prevent...
To identify different microbial species in women with polycystic ovary syndrome (PCOS) and reveal a possible relationship between gut dysbiosis pathological changes.Cross-sectional study.Academic institution.Reproductive-aged PCOS (n = 14) controls from the Centre for Reproductive Medicine.Shotgun metagenomic sequencing on fecal samples patients, clinical parameters (including body mass index, endocrine hormone levels, glycemia level) gathered correlation analysis.Identification of strains...
A number of genes involved in zygotic genome activation (ZGA) have been identified, but the RNA-binding maternal factors that are directly related to ZGA mice remain unclear. The present study shows deletion Igf 2bp2 (also commonly known as Imp2) mouse embryos causes early embryonic developmental arrest vitro at 2-cell-stage. Transcriptomics and proteomics analyses 2-cell-stage reveal IMP2 downregulates expression Ccar1 Rps14, both which required for competence. IGF2, a target IMP2, when...
Polycystic ovary syndrome (PCOS) is an endocrine-related disease and global cause of infertility that associated with abnormal folliculogenesis. Inhibited granulosa cell (GC) proliferation recognized as a key factor underlies aberrant follicle maturation. Many epigenetic landscape modifications have been characterized in PCOS patients. However, the regulation pathways follicular dysplasia are not completely understood. In this study, we reported novel mechanism DNA hypomethylation induced by...
Implantation failure remains a critical barrier to in vitro fertilization. Prednisone, as an immune-regulatory agent, is widely used improve the probability of implantation and pregnancy, although evidence for efficacy inadequate.To determine 10 mg prednisone compared with placebo on live birth among women recurrent failure.A double-blind, placebo-controlled, randomized clinical trial conducted at 8 fertility centers China. Eligible who had history 2 or more unsuccessful embryo transfer...
Abstract STUDY QUESTION Does ovarian ferroptosis play an active role in the development of polycystic ovary syndrome (PCOS)? SUMMARY ANSWER Increased was present PCOS ovaries and inhibition with ferrostatin-1 (Fer-1) ameliorated morphology anovulation. WHAT IS KNOWN ALREADY Programmed cell death plays a fundamental follicle development. However, types mechanisms involved are yet to be elucidated. Ferroptosis is recently discovered iron-dependent programmed death. Impaired iron metabolism...
Ovarian follicle selection is an important process impacting the laying performance and fecundity of hens, regulated by follicle-stimulating hormone (FSH) through binding to its receptor (FSHR). In small yellow (6–8 mm in diameter) with highest expression FSHR will be recruited into preovulatory hierarchy during ovarian development.The study molecular mechanism chicken helpful for identification genes underlying egg traits other poultry species. Herein, transcriptomes follicles differing...
Disordered folliculogenesis is a key feature of polycystic ovary syndrome (PCOS), but the underlying molecular mechanism remains unclear.
The interplay between genetic and environmental risk factors contributes to the pathogenesis of metabolic disease. Polycystic ovary syndrome (PCOS) is most common endocrine disorder in women reproductive age. Circadian rhythm disruption an important factor for PCOS. In this study, we evaluated effect circadian on reproduction as well metabolism, determined its influence gut microbiota a rat model. Female Sprague Dawley rats were kept under continuous light exposure (12-h:12-h light/light...
Abstract Problem For women of reproductive age, achieving a successful pregnancy requires both the normal functioning endocrine and health tract environment. We aimed to study how these fertility factors, such as female baseline sexual hormone levels, tubal patency, vaginal pH, affect composition microbiome. Method The 16S rRNA sequencing was carried on microbiome samples from 85 age without infections or diseases. detailed correlations between factors were quantified by Spearman's rank...
Endometrial decidualization is a prerequisite for implantation, and impaired associated with recurrent implantation failure (RIF). Coding genes of the HOX family have been clarified as critical regulators in endometrial decidualization, but role long non-coding RNAs (lncRNAs) gene has yet to be determined. The aim this study was clarify possible roles lncRNAs decidualization. In study, we identified that HOXA11-AS most reduced lncRNA human endometrium during window it elevated RIF patients....
Abstract Background Peripheral arterial disease (PAD), a major manifestation of atherosclerosis, is associated with significant cardiovascular morbidity, limb loss and death. However, mechanisms underlying the genesis progression are far from clear. Genome-wide gene expression profiling clinical samples may represent an effective approach to gain relevant information. Results After histological classification, total 30 femoral artery samples, including 11 intermediate lesions, 14 advanced...
A recent genome-wide association study (GWAS) has identified three susceptibility loci (8p32.1, 11p14.1, and 9q22.32) for polycystic ovary syndrome (PCOS) in women of European ancestry. The 9q22.32 locus was previously found our Chinese PCOS GWAS. Replication the other two is necessary to determine whether same variants confer risk Han women.This aimed investigate effect GWAS on a genetic at university hospital composed 1601 cases 1238 age-matched controls. Interventions Main Outcome...
Do oral contraceptives (OCs) and progestins impact live birth rate of IVF when used for cycle scheduling in women with polycystic ovary syndrome (PCOS)? OCs were associated lowered rates pregnancy after fresh embryo transfer, whereas this purpose yield higher than OCs. Due to oligo-menorrhea PCOS, progestin are extensively schedule the start an PCOS. Little is known about effect such pretreatments on outcomes, especially, birth. This was a nested cohort study secondary analysis multicenter...