A5101481211- Neuroblastoma Research and Treatments
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Cancer, Hypoxia, and Metabolism
- Ginger and Zingiberaceae research
- Microbial Metabolites in Food Biotechnology
- Reproductive Biology and Fertility
- Tissue Engineering and Regenerative Medicine
- Phytochemistry and biological activity of medicinal plants
- Infant Nutrition and Health
- Ovarian function and disorders
- MicroRNA in disease regulation
- Congenital Diaphragmatic Hernia Studies
- Seaweed-derived Bioactive Compounds
- Ginseng Biological Effects and Applications
- Mental Health Research Topics
- Toxin Mechanisms and Immunotoxins
- Antioxidant Activity and Oxidative Stress
- Ultrasound and Hyperthermia Applications
- Education in Diverse Contexts
- Higher Education Learning Practices
- Tannin, Tannase and Anticancer Activities
- Simulation-Based Education in Healthcare
- Abdominal Surgery and Complications
- Apelin-related biomedical research
Shanghai Jiao Tong University
2016-2024
Zhejiang Marine Fisheries Research Institute
2023-2024
Ministry of Agriculture and Rural Affairs
2024
Tongren Hospital
2024
University of Science and Technology of China
2024
Nanjing Medical University
2024
Community Health Center
2024
Zhejiang University of Technology
2023
Huazhong University of Science and Technology
2022-2023
Union Hospital
2022-2023
Neuroblastoma (NB) is a kind of typical life-threatening extracranial tumor in children. N6-methyladenosine (m6A) modification closely related to multiple cancer pathological processes. Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) top-ranked prognostic risk gene NB; however, its function uncertain. The expression m6A-associated enzymes patients with NB was analyzed using the Gene Expression Omnibus (GEO) and Therapeutically Applicable Research Generate Effective Treatments...
Ferroptosis is an iron-dependent cell death process mainly triggered by reactive oxygen species (ROS) and lipid peroxidation. Thioredoxin domain protein 12 (TXNDC12) promotes the development of some tumors; however, its function in tumor ferroptosis remains unclear. In this study, we found that knockdown TXNDC12 promoted erastin-induced increase ROS, peroxidation, Fe2+ levels, decreased glutathione content. involved regulating SLC7A11. Further studies showed decrease glioma viability....
Dendrobium candidum Wall ex Lindl. was purchased for the evaluation of azoxymethane (AOM)‑ and dextran sulfate sodium (DSS)‑induced colon carcinogenesis in C57BL/6 mice. The body weights AOM‑ DSS‑induced cancer control groups were lighter than those untreated D. increased mice compared with group, reduced levels serum proinflammatory cytokines, IL‑6, IL‑12, TNF‑α IFN‑γ, group. Reverse transcription‑polymerase chain reaction western blot analyses apoptotic‑related genes, bax, bcl‑2, caspase‑3...
Background: Neuroblastoma (NB) is a pediatric cancer occurring in the peripheral nervous system. A demethylase, alkylation repair homolog protein 5 (ALKBH5), one type of N6-methyladenosine (m6A) eraser that plays tumor-suppressive role variety cancers. The significance carbohydrate metabolism has been intensively investigated over years, but correlation between ALKBH5 and glucose NB remains to be elucidated. Methods: Based on overlapped genes (DE-GRGs) ALKBH5-related differentially expressed...
Shuidouchi (Natto) is a fermented soy product showing in vivo gastric injury preventive effects. The treatment effects of different vessels on HCl/ethanol-induced mucosal mice through their antioxidant effect was determined. contained isoflavones (daidzein and genistein), GVFS (glass vessel Shuidouchi) had the highest isoflavone levels among samples vessels. After with GVFS, reduced as compared to control mice. secretion volume (0.47 mL) pH juice (3.1) treated were close those...
The aim of the present study was to evaluate preventive effects banana peel polyphenols (BPPs) against hepatic injury. Mice were divide into normal, control, 100 mg/kg and 200 polyphenol silymarin groups. All mice except normal induced with damage using CCl4. serum tissue levels determined by a kit tissues further examined reverse transcription-quantitative polymerase chain reaction (RT‑qPCR) western blot analysis. BPPs reduced aspartate aminotransferase, alanine aminotransferase lactate...
Human mesenchymal stem cells (hMSCs) have been applied in a variety of therapies recently. However, the role MSCs tumor progression remains largely elusive. Some studies demonstrated that can promote growth, while others had opposite results. Therefore, lack evidence about effect on impedes its further use.In current study, hMSCs from amniotic membrane (hAMSCs) and umbilical cord (hUCMSCs) were used to evaluate effects development vitro vivo. Two different animal models based subcutaneous...
The aim of this study was to determine the effects resistant starch 3 (RS3) as a carrier for stachyose on dextran sulfate sodium (DSS)‑induced colitis in C57BL/6 mice. RS3 microspheres carrying (RS3 + stachyose) were produced and evaluated potentially improved therapy study. body weights mice treated with higher compared those DSS-treated control reduced levels serum pro-inflammatory cytokines IL-6 TNF-α greater extent same concentration combined ordinary (stachyose starch)....
In the present study preventive effect of polysaccharides from large yellow croaker swim bladder (PLYCSB) on HCl/ethanol-induced gastric injury in ICR mice was investigated. A high dose PLYCSB (50 mg/kg) found to reduce levels serum proinflammatory cytokines interleukin (IL)-1β, IL-6, IL-8, as well increase IL-4 compared with those treated a low (25 and control mice. The somatostatin vasoactive intestinal peptide PLYCSB-treated were higher mice, whilst motilin substance P lower extent that...
Necrotizing enterocolitis (NEC) is characterized by a rich infiltration of macrophages in the intestines, which derived from monocytes blood. The authors aimed to explore changing trend absolute monocyte counts (AMC) over time NEC infants and verify whether reduction AMC correlates with severity it can be used identify who need surgery.The collected clinical data 66 control 222 infants. were divided into medical (M-NEC) surgical (S-NEC). counting their percentage change compared at birth,...
Neuroblastoma (NB) is the most common extracranial solid tumor occurring during childhood and high-risk NB patients have a poor prognosis. The amplified MYCN gene serves as an important determinant of high risk NB.We performed integrative screen using public tissue cell line data, identified that SMAD9 played role in NB. An investigation super-enhancers database (SEdb) chromatin immunoprecipitation sequencing (ChIP-seq) dataset along with biological experiments incorporating knockdown CRISPR...
Polycystic ovary syndrome, a common condition characterized by endocrine dysfunction, menstrual irregularity, anovulation and polycystic ovaries, affects 5–7% of reproductive-age women. RAB5B , which is identified genome-wide association study as risk locus for this encodes small GTPase involved in control receptor internalization early endosome fusion. We found that RAB5A mRNA levels luteinized granulosa cells obese patients with syndrome were lower than those women without the syndrome....
Abstract RNF7 has been reported to play critical roles in various cancers. However, the underlying mechanisms of glioma development remain largely unknown. Herein, expression level was examined tissues by quantitative real‐time PCR, Western blotting and immunohistochemistry. The effect on progression measured performing CCK‐8 apoptosis assays, cell cycle‐related experiments animal experiments. PI3K/AKT signalling pathway tested blotting. First, we found that upregulated tumour tissue...
The antitumor activity of Juemingzi (Cassia tora L.) was investigated in mice that were fed various concentrations the compound. Although a low concentration (50 mg/kg b.w.) exhibited high tumor weight, higher feeding (100 and 200 associated with lower weight tumors. growth rate mouse splenocytes treated b.w. determined using 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide assay. This proliferation than achieved 100 50 treatment by fetal bovine serum, lipopolysaccharide or...
Abstract Background Despite the presence of evidence indicating a correlation between Acute Pancreatitis (AP) and Major Depressive Disorder (MDD), precise mechanisms underlying co-occurrence these two conditions remain unclear. The aim this study was to investigate potential crosstalk genes, pathways immune cell AP MDD. Methods We downloaded MDD data from Gene Expression Omnibus (GEO) database. Shared genes were identified using differential expression analysis weighted gene co-expression...
To effectively distinguish natural and cultured populations of Oplegnathus fasciatus, we used both traditional statistical analysis neural network methods to compare six shape indices twenty-one truss from otoliths 174 randomly selected specimens (100 a population 74 population). The results showed that among the indices, ellipticity, roundness, aspect ratio exhibited significant differences between two populations. Twelve out displayed differences. Results discriminant indicated achieved...
A black tea product was evaluated for anti-mutagenic and in vivo anticancer effects. At concentrations of 1.25 2.5 mg/plate, exhibited anti-mutagenicity with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) the Salmonella typhimurium TA100 strain. Kunming (KM) mouse buccal mucosa cancer model established by injecting mice U14 squamous cell carcinoma cells. Following injection, wound at injection site smeared tea. It observed that tumor volumes groups treated different were smaller than control...
Background: This project's aim was to explore the enhancing effect of contrast media on primary cancer and cervical metastatic lymph nodes cheek carcinoma by local injection.Materials Methods: Lymphatic metastasis mice models were established, then self-made administered into harmonic mode imaging performed observe enhancement lesions nodes.Results: The echo intensity (EI) compared. detection rate inflammatory 61% (17/28) 50% (6/12) before contrast-enhanced ultrasound (CEUS) 82% (23/28) 75%...