A5081036640- Pancreatitis Pathology and Treatment
- Lipid metabolism and disorders
- Pancreatic and Hepatic Oncology Research
- Acute Kidney Injury Research
- Traditional Chinese Medicine Studies
- Sepsis Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Drug-Induced Hepatotoxicity and Protection
- Vitamin C and Antioxidants Research
- MicroRNA in disease regulation
- Circadian rhythm and melatonin
- Inflammatory Myopathies and Dermatomyositis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacological Effects of Natural Compounds
- Ginseng Biological Effects and Applications
- Acupuncture Treatment Research Studies
- Sodium Intake and Health
- Systemic Sclerosis and Related Diseases
- Medicinal Plants and Bioactive Compounds
- Diabetes Treatment and Management
- Blood transfusion and management
- Apelin-related biomedical research
- Bone and Joint Diseases
- Biochemical and Molecular Research
- Pharmacogenetics and Drug Metabolism
Nanjing University
2022
Nanjing General Hospital of Nanjing Military Command
2022
Zhejiang University
2007-2021
Sir Run Run Shaw Hospital
2007-2021
Fujian Medical University
2021
The incidence of hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is increasing. Plasmapheresis theoretically effective in removing triglyceride from plasma, but whether it confers clinical benefits unclear.To assess the association between plasmapheresis and duration organ failure among patients with HTG-AP.This an a priori analysis data multicenter, prospective cohort study enrolled 28 sites across China. Patients HTG-AP were admitted within 72 hours disease onset. first patient...
Septic patients suffer a 'cytokine storm' from proinflammatory cytokines, chemokines and other inflammatory mediators, resulting in acute kidney injury (AKI) death. The purpose of the present study was to determine expression patterns microRNA-210 (miR-210), miR-494, miR-205 middle-aged old with sepsis-induced AKI evaluate their association patient prognosis. Serum blood urea nitrogen (BUN), creatinine (Cr) cystatin C levels were determined peripheral venous collected 110 healthy controls....
The role of double filtration plasmapheresis (DFPP) in hypertriglyceridemic pancreatitis (HTGP) is still not well established. Our study aimed to investigate the efficacy DFPP reducing triglyceride levels as their effects on outcomes HTGP.We retrospectively evaluated data patients with HTGP presenting within 72 hours from symptom onset between January 2016 and February 2019. Patients treatment were compared those without treatment. We used a propensity score matching analysis reduce...
Abstract Background Plasmapheresis is widely used for severe hypertriglyceridemia-associated acute pancreatitis (HTG-AP) to remove excessive triglycerides from plasma. This study aimed evaluate whether plasmapheresis could improve the duration of organ failure in HTG-AP patients. Methods We analyzed a cohort patients multicenter, prospective, long-running registry (the PERFORM) collecting admitted sites within 72 h onset symptoms. was based on data collected November 2020 March 2023....
Abstract Although increasing evidence has confirmed that the apoptosis of renal tubular epithelial cells (RTECs) is a crucial contributor to onset and development septic acute kidney injury (AKI), pathological mechanism by which RTEC upregulated during AKI not entirely clear. In this study, rat model was induced cecal ligation puncture procedure or lipopolysaccharide (LPS) injection. Four differentially expressed long noncoding RNAs (DE-Lncs) in were determined using RNA-sequencing verified...
Acute pancreatitis (AP) has a fast onset and progression, which lead to an unfavorable prognosis. Therefore, the development of novel drugs for its treatment is critical. As homologous derivative resveratrol, pterostilbene exerts variety effects including anti-inflammatory, antioxidant, antitumor effects. This study investigated potential severe AP (SAP) related mechanisms. Effects were evaluated in Wistar rat model AP. Serum levels amylase (AMY), creatinine (Cr), alanine aminotransferase...
Agomelatine is a non-selective melatonin receptor agonist and an atypical antidepressant with anti-inflammatory, neuroprotective, cardioprotective effects. The renin-angiotensin system modulates blood pressure vascular homeostasis. Angiotensin II (Ang II) its Ang type I (AT1R) are recognized as contributors to the pathogenesis of cardiovascular cardiometabolic diseases, including diabetes, obesity, atherosclerosis. recruitment attachment monocytes endothelium major event in early stages...
Abstract To explore the clinical characteristics of systemic sclerosis complicated with silicosis. The patients treated in Guangxi Workers’ Hospital and People's Zhuang Autonomous Region from January 2000 to December 2020 were divided into silicosis group without group. Survival analysis was performed using Kaplan–Meier estimates Cox proportional hazards model. A propensity score matching applied order avoid selection bias. Over past 20 years, 72 238 two hospitals. had more males ( P <...
To investigate the dynamic change of lipid profile under double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced acute pancreatitis (sHTGP) patients and ascertain association between these changes clinical prognosis.sHTGP admitted within 72 h after disease onset were included, all received DFPP 24 admission. Lipid detected on admission, consecutive 4 days at discharge.There 47 sHTGP enrolled this study. At parameters changed significantly except for low density...
Abstract Background: To investigate the dynamic change of lipid profile under double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced acute pancreatitis (sHTGP) patients and ascertain association between these changes clinical prognosis. Methods: sHTGP admitted within 72h after disease onset were included, all received DFPP 24h admission. Lipid detected on admission, consecutive 4 days at discharge. Results: There 47 enrolled this study. At parameters changed...
Abstract Background: In this study, we aimed to investigate the dynamic changes of lipid profile under double filtration plasmapheresis (DFPP) in severe hypertriglyceridemia-induced acute pancreatitis (sHTGP) patients and ascertain whether these were associated with prognosis disease. Methods: This retrospective study was conducted at a tertiary critical care center China. We included sHTGP who admitted within 72h after AP onset. All received DFPP 24h admission. Lipid measured 47 on...